在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRKACB Antibody, FITC conjugated

  • 中文名稱:
    PRKACB兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA018689LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRKACB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody; cAMP-dependent protein kinase catalytic subunit beta antibody; KAPCB_HUMAN antibody; PKA C beta antibody; PKA C-beta antibody; PKACB antibody; Prkacb antibody; protein kinase A catalytic subunit beta antibody; Protein kinase cAMP dependent catalytic beta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human cAMP-dependent protein kinase catalytic subunit beta protein (2-53AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA.
  • 基因功能參考文獻:
    1. Cbeta2 subunit of protein kinase A mRNA was up-regulated in prostate cancer and low expression of Cbeta2 mRNA in prostate cancer biopsies correlated with poor survival. PMID: 27838142
    2. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 PMID: 25831493
    3. The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation. PMID: 24294386
    4. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. PMID: 20564261
    5. activated by podophyllotoxin PMID: 20033853
    6. PGE(2)-induced CYP1B1 expression is mediated by ligand-independent activation of the ERalpha pathway as a result of the activation of ERK, Akt, and PKA in breast cancer cells. PMID: 20093341
    7. Data show that PI3K activation and PIP3 production lead to recruitment of the PKB/beta-arrestin/PDE4 complex to the membrane via the PKB PH domain, resulting in degradation of the TCR-induced cAMP pool and allowing full T-cell activation to proceed. PMID: 20086095
    8. c-MYC induces the activity of protein kinase A by inducing the transcription of the gene encoding the PKA catalytic subunit beta in multiple tissues, independent of cell proliferation by direct binding of c-MYC to promoter sequences. PMID: 12420224
    9. Data describe the identification of a variant of the beta catalytic subunit of cyclic AMP-dependent protein kinase (PKACbeta) as a p75 neurotrophin receptor(NTR)-interacting protein, which phosphorylates p75(NTR) at Ser304. PMID: 12682012
    10. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta. PMID: 14744463
    11. there is a PKA-Cbeta-mediated inhibitory mechanism of p73 function PMID: 15723830
    12. Murine lymphoid tissues express a protein that is a homologue of human protein kinase c subunit beta2 PMID: 16889664
    13. In conclusion, it seems that the Cbeta isoforms of PKA play different roles in proliferation and differentiation and could therefore be potential markers for prostate cancer progression. PMID: 16949795
    14. Data provide the first evidence that Protein kinase C -beta play pivotal role in the regulation of AA production and cellular proliferation of human monocytoid MonoMac-6 cells. PMID: 17549442
    15. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. PMID: 18499756

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
  • 組織特異性:
    Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
  • 數據庫鏈接:

    HGNC: 9381

    OMIM: 176892

    KEGG: hsa:5567

    STRING: 9606.ENSP00000359719

    UniGene: Hs.487325



主站蜘蛛池模板: 国内精品一区二区三区| 亚洲精品福利一区二区三区蜜桃| 中国性欧美videofree精品| 亚洲国产精品自在拍在线播放蜜臀 | 亚洲欧美国产va在线播放| 亚洲理论电影在线观看| 中文区中文字幕免费看| 一本丁香综合久久久久不卡网站| 国产破外女出血视频| 日本少妇浓毛bbwbbwbbw| 国产成人一区二区三区app | 国产爆乳美女娇喘呻吟| 丰满少妇被粗大的猛烈进出视频| 成年女人午夜性视频| 国产亚洲精品久久久久丝瓜| 久久婷婷五月国产色综合| 羞羞色男人的天堂| 国语自产精品视频在 视频| 无码国模国产在线观看| 亚洲五月综合缴情在线| 18禁勿入午夜网站入口| 国产精品白丝喷浆| 巨大欧美黑人xxxxbbbb| 男人和女人高潮免费网站| 国产精品亚洲а∨天堂免下载| 国产午夜无码片在线观看网站| 国产公开免费人成视频| 50路60路老熟妇啪啪| 亚洲动漫精品无码av天堂| 国产在线清纯极品美女援交| 永久免费无码av网站在线观看| 精品人妻大屁股白浆无码| 亚洲国产成人无码av在线影院| 色av专区无码影音先锋| 国产午夜片无码区在线播放| 黑人巨茎大战俄罗斯美女| 免费h动漫无码网站| 欧美另类精品xxxx人妖| 中文字幕人妻无码视频| 成人亚洲精品久久久久| 777午夜福利理伦电影网|