在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRIM1 Antibody

  • 中文名稱:
    PRIM1兔多克隆抗體
  • 貨號:
    CSB-PA018680GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AI324982 antibody; DNA primase 49 kDa subunit antibody; DNA primase small subunit antibody; MGC107288 antibody; MGC109113 antibody; p49 antibody; PRI1_HUMAN antibody; PRIM1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PRIM1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit. Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end. Binds single stranded DNA.
  • 基因功能參考文獻:
    1. No mutations within PRIM1 were found in Chinese women with primary ovarian insufficiency. PMID: 27599756
    2. Data suggest that PRIM1-p58,C-terminal domain stays bound to initiating NTP and 3prime-overhang DNA during whole cycle of RNA primer synthesis; meanwhile, PRIM1-p49 slides along DNA template toward 5prime-end with PRIM1-p58,N-terminal domain attached. PMID: 26710848
    3. Data indicate that the conformational changes in primase are necessary to accomplish the initiation and then elongation of RNA synthesis. PMID: 25550159
    4. Findings indicate that tethering of DNA primase Prim1 to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells. PMID: 22593576
    5. Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate PMID: 20030400

    顯示更多

    收起更多

  • 蛋白家族:
    Eukaryotic-type primase small subunit family
  • 數據庫鏈接:

    HGNC: 9369

    OMIM: 176635

    KEGG: hsa:5557

    STRING: 9606.ENSP00000350491

    UniGene: Hs.534339



主站蜘蛛池模板: 国产亚洲精品久久久网站好莱| 在线a毛片免费视频观看| 国产av天堂亚洲国产av天堂| 亚洲色大成网站www永久男同| 99久久国产综合精品swag| a 'v片欧美日韩在线| 狠狠色狠狠人格综合| 亚洲精品成人av观看| 亚洲精品乱码久久久久久中文字幕| 欧美饥渴熟妇高潮喷水水| 欧美三级不卡在线观看| 欧美激欧美啪啪片免费看| 国产精品星空无限传媒| 亚洲情a成黄在线观看| 黑人大荫蒂老太大| 日韩成人无码| 18禁亚洲深夜福利入口| 天天摸天天做天天添欧美| 精产国品一二三产品蜜桃| 亚洲不卡中文字幕无码| 久久久久人妻精品一区三寸| 亚洲第一最快av网站| 在线观看国产精品av| 久久精品aⅴ无码中文字字幕蜜桃| 无码av无码天堂资源网| 欧美孕妇乳喷奶水在线观看| 蜜桃日本免费观看mv| 国语自产精品视频在线第100页| 亚洲国产中文在线二区三区免| 日本丰满少妇高潮呻吟| 日韩精品一区二区av在线| 国产伦精品一区二区三区免.费| 免费大片黄在线观看| 中文字幕无码免费不卡视频| 成人精品免费视频在线观看| 粗大黑人巨精大战欧美成人| 天堂资源在线www中文| 亚洲欧洲日产韩国无码| 日本又黄又爽gif动态图| 亚洲午夜av久久久精品影院| 成人亚洲a片v一区二区三区蜜臀|