在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRIM1 Antibody, FITC conjugated

  • 中文名稱:
    PRIM1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA018680LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PRIM1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AI324982 antibody; DNA primase 49 kDa subunit antibody; DNA primase small subunit antibody; MGC107288 antibody; MGC109113 antibody; p49 antibody; PRI1_HUMAN antibody; PRIM1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human DNA primase small subunit protein (1-420AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit. Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end. Binds single stranded DNA.
  • 基因功能參考文獻(xiàn):
    1. No mutations within PRIM1 were found in Chinese women with primary ovarian insufficiency. PMID: 27599756
    2. Data suggest that PRIM1-p58,C-terminal domain stays bound to initiating NTP and 3prime-overhang DNA during whole cycle of RNA primer synthesis; meanwhile, PRIM1-p49 slides along DNA template toward 5prime-end with PRIM1-p58,N-terminal domain attached. PMID: 26710848
    3. Data indicate that the conformational changes in primase are necessary to accomplish the initiation and then elongation of RNA synthesis. PMID: 25550159
    4. Findings indicate that tethering of DNA primase Prim1 to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells. PMID: 22593576
    5. Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate PMID: 20030400

    顯示更多

    收起更多

  • 蛋白家族:
    Eukaryotic-type primase small subunit family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9369

    OMIM: 176635

    KEGG: hsa:5557

    STRING: 9606.ENSP00000350491

    UniGene: Hs.534339



主站蜘蛛池模板: 日韩一区二区三区射精-百度| 国色天香在线视频www| 亚洲蜜桃精久久久久久久久久久久| 国产亚洲精久久久久久无码| 精品国产成人亚洲午夜福利| 午夜福利国产成人无码gif动图| 男男女女爽爽爽免费视频| 制服丝袜亚洲中文欧美在线| 99在线精品国自产拍| 99久热在线精品视频观看| 亚洲国产成人va在线观看天堂| 肉感饱满中年熟妇日本| 久9视频这里只有精品试看| 久久国产乱子伦精品免费台湾| 国产sm重味一区二区三区| 日韩精品成人无码专区免费| 日本三级手机在线播放线观看| 美女扒开奶罩露出奶头视频网站| 蜜桃少妇av久久久久久久| 亚洲精品无播放器在线播放| 鲁丝一区二区三区免费| 成人综合婷婷国产精品久久| 熟妇丰满大屁股在线播放| 亚洲欧洲成人a∨在线| 久久这里只有精品首页| 久久99精品久久久久婷婷暖| 2020久久天天躁狠狠躁夜夜| 久久日本片精品aaaaa国产| 男女作爱免费网站| 国产精品久久久久蜜臀| 草裙社区精品视频三区免费看| 亚洲精品国偷拍自产在线麻豆| 粉嫩少妇内射浓精videos| 亚洲成a∨人片在无码2023| av无码中出一区二区三区| 欧美xxxx做受性欧美88| 国产乱人伦偷精品视频免下载| 中国少妇初尝黑人巨高清 | 久久国产精品波多野结衣av| 久久国产36精品色熟妇| 尤物av无码国产在线看|