在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PPIB Antibody

  • 中文名稱:
    PPIB兔多克隆抗體
  • 貨號:
    CSB-PA018472GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PPIB
  • 別名:
    AA408962 antibody; AA553318 antibody; AI844835 antibody; Cphn 2 antibody; Cphn2 antibody; Cyclophilin B antibody; Cyclophilin like protein antibody; CyP 20b antibody; CYP S1 antibody; CYP-S1 antibody; CYPB antibody; EC 5.2.1.8 antibody; MGC14109 antibody; MGC2224 antibody; OI9 antibody; peptidyl prolyl cis trans isomerase B antibody; Peptidyl prolyl cis trans isomerase B precursor antibody; Peptidyl-prolyl cis-trans isomerase B antibody; peptidylprolyl isomerase B (cyclophilin B) antibody; Peptidylprolyl isomerase B antibody; PPIase antibody; PPIase B antibody; Ppib antibody; PPIB_HUMAN antibody; Rotamase antibody; Rotamase B antibody; S cyclophilin antibody; S-cyclophilin antibody; SCYLP antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PPIB
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
  • 基因功能參考文獻:
    1. A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo. PMID: 30430148
    2. Data show that Cyclophilin B is present on the erythrocytes and binds strongly to merozoites. PMID: 29146974
    3. cyclophilin B (CYPB) functions in protecting cells against aldosterone-induced oxidative stress, endoplasmic reticulum stress (ERS) and tubular cell injury via its peptidyl-prolyl cis-trans isomerase (PPIase) activity. PMID: 27732567
    4. PPIB mutations and their associated phenotypes PMID: 28242392
    5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. PMID: 28385890
    6. The data suggest that overexpressed CypB protects neuronal cells from MPP+-induced dopaminergic neuronal cell death PMID: 27569281
    7. This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP, and PPIB genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI. PMID: 26634552
    8. Over-expression of CypB enhances HIV infection by increasing nuclear import of viral DNA. PMID: 26774171
    9. Cyclophilin B has a high diagnostic value for stomach cancer and its downregulation can effectively inhibit the growth of stomach cancer cells. Thus, cyclophilin B may be a potential therapeutic target for stomach cancer treatment PMID: 26125731
    10. The extracellular portion of cyclophilin B probably plays an important role in human diseases associated with acute or chronic inflammation PMID: 24713575
    11. Findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia. PMID: 24270407
    12. These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis PMID: 24990953
    13. Cyclophilin B is a novel MDM2 interacting partner. PMID: 24583282
    14. cyclophilin B (CypB) is a prolyl isomerase residing in the endoplasmic reticulum (ER), that provides an essential survival signal in glioblastoma multiforme cells through myc and mutant p53 PMID: 24272483
    15. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. PMID: 24043621
    16. Cyclophilin B activity regulated secretion and activity of ADAMTS13. PMID: 23144461
    17. CypB has an essential function in protecting hepatoma cells against oxidative stress through binding to CD147 and regulating the ERK pathway PMID: 22555451
    18. these findings suggest an unexpected role for cyclophilin B in attenuation of the responses of proinflammatory macrophages PMID: 22798670
    19. CypB interacts with these proteins and is involved in ribosome biogenesis and RNA transcription. PMID: 22426501
    20. Cyclophilin B is a candidate pancreatic cancer biomarker. PMID: 22484812
    21. CypB induced by hypoxia stimulates the survival of hepatocellular carcinoma via a positive feedback loop with HIF-1alpha. PMID: 21748762
    22. CAHL is a CsA associated helicase-like protein, which would form trimer complex with cyclophilin B and NS5B of HCV PMID: 21559518
    23. peptidylprolyl cis-trans isomerase B may be required to effectively fold the proline-rich regions of the C-terminal propeptide of procollagen PMID: 21282188
    24. cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity. PMID: 21257749
    25. These results suggest that CypB plays a crucial role in the replication of Japanese encephalitis virus through an interaction with NS4A. PMID: 21281954
    26. Data indicate that CypB through its interaction with Na/K-beta1 might regulate maturation and trafficking of the pump through the secretory pathway. PMID: 21085665
    27. Results reveal the P-domain functions as a unique protein-protein interaction domain and implicate a peptidyl prolyl isomerase as a new element in the calnexin cycle. PMID: 20801878
    28. Cyclophilin B significantly modulate prolactin-induced function in breast cancer cells, ultimately resulting in enhanced levels of prolactin-responsive gene expression, cell growth, and migration. PMID: 20237142
    29. a regulatory mechanism in which cell type-specific expression of certain heparan sulfate sulfotransferases determines the specific binding of CyPB to target cells PMID: 19940140
    30. calcium signaling through CD147 receptor; induces neutrophil chemotaxis PMID: 11688976
    31. act in the context of t lymphocyte recruitment and function PMID: 11867726
    32. Different regions of CyPB are involved in peripheral blood T-lymphocyte activation and imply an important physiological function for peptidylprolyl isomerase activity. PMID: 11955071
    33. Inhibition of the PT-pore (ANT-1) via up-regulation of cyclophilin D plays a role in tumorigenesis PMID: 14729611
    34. Cyclophilin B plays a critical role in the activation of interferon regulatory factor-3. PMID: 15764595
    35. CYPB is a functional rfegulator of hepacivirus RNA polymerase. PMID: 15989969
    36. results strongly support the hypothesis that 3-O-sulfation of GlcNH2 residues could be a key modification that provides specialized HS structures for CyPB binding to responsive cells PMID: 17588944
    37. Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins. PMID: 18054915
    38. CypB is a new TRPV6 accessory protein with potential involvement in TRPV6 channel activation through its peptidyl-prolyl cis/trans isomerase activity PMID: 18445599
    39. the enhanced expression of CypB in malignant breast epithelium may contribute to the pathogenesis of this disease PMID: 19056847
    40. PPIB mutations cause severe osteogenesis imperfecta PMID: 19781681

    顯示更多

    收起更多

  • 相關疾病:
    Osteogenesis imperfecta 9 (OI9)
  • 亞細胞定位:
    Virion.
  • 蛋白家族:
    Cyclophilin-type PPIase family, PPIase B subfamily
  • 數據庫鏈接:

    HGNC: 9255

    OMIM: 123841

    KEGG: hsa:5479

    STRING: 9606.ENSP00000300026

    UniGene: Hs.434937



主站蜘蛛池模板: 欧美国产日韩亚洲中文| 老子影院午夜伦不卡无码| 久久精品国产精品亚洲38| 色琪琪丁香婷婷综合久久| 无码人妻一区二区三区av | 韩国三级中文字幕hd| 一本大道无码日韩精品影视丶| 亚洲精品久久久久久下一站| 丰满少妇被粗大的猛烈进出视频| 尹人香蕉久久99天天拍欧美p7| 国产又色又爽又黄的视频在线观看 | 国产a精彩视频精品视频下载| 成人午夜免费无码区| 国产成人av在线一区二区三区| 四虎国产精品永久在线观看| 国产精品久久久久久久久久久不卡| 久久久久99人妻一区二区三区| 国产一区二区无码蜜芽精品 | 日本少妇肉体裸交xxx| 国产性天天综合网| 亚洲另类春色校园小说| 少妇下蹲露大唇无遮挡| 亚洲综合久久精品无码色欲| 亚洲精品成人av观看| 性欧美大战久久久久久久| 国产精品igao视频| 日本三级理论久久人妻电影| 久久久久国产精品人妻aⅴ四季| 久久精品人人做人人爽97| 天堂а在线中文在线新版| 一区二区三区无码被窝影院| 国产极品精品自在线| 亚洲中文字幕无码天然素人| 天天天狠天天碰天天爱| www夜插内射视频网站| 国产极品美女到高潮| 末发育女av片一区二区| 久久久久久好爽爽久久| 国产精品无码一区二区三区电影 | 成年午夜性影院免费观看| 午夜人成免费视频|