在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PPIB Antibody

  • 中文名稱:
    PPIB兔多克隆抗體
  • 貨號:
    CSB-PA906437
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA906437(PPIB Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA906437(PPIB Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal liver tissue, 293T cells, human liver cancer tissue, hela cells, Primary antibody: CSB-PA906437(PPIB Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PPIB
  • 別名:
    AA408962 antibody; AA553318 antibody; AI844835 antibody; Cphn 2 antibody; Cphn2 antibody; Cyclophilin B antibody; Cyclophilin like protein antibody; CyP 20b antibody; CYP S1 antibody; CYP-S1 antibody; CYPB antibody; EC 5.2.1.8 antibody; MGC14109 antibody; MGC2224 antibody; OI9 antibody; peptidyl prolyl cis trans isomerase B antibody; Peptidyl prolyl cis trans isomerase B precursor antibody; Peptidyl-prolyl cis-trans isomerase B antibody; peptidylprolyl isomerase B (cyclophilin B) antibody; Peptidylprolyl isomerase B antibody; PPIase antibody; PPIase B antibody; Ppib antibody; PPIB_HUMAN antibody; Rotamase antibody; Rotamase B antibody; S cyclophilin antibody; S-cyclophilin antibody; SCYLP antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human PPIB
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:100-1:300
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
  • 基因功能參考文獻:
    1. A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo. PMID: 30430148
    2. Data show that Cyclophilin B is present on the erythrocytes and binds strongly to merozoites. PMID: 29146974
    3. cyclophilin B (CYPB) functions in protecting cells against aldosterone-induced oxidative stress, endoplasmic reticulum stress (ERS) and tubular cell injury via its peptidyl-prolyl cis-trans isomerase (PPIase) activity. PMID: 27732567
    4. PPIB mutations and their associated phenotypes PMID: 28242392
    5. observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. PMID: 28385890
    6. The data suggest that overexpressed CypB protects neuronal cells from MPP+-induced dopaminergic neuronal cell death PMID: 27569281
    7. This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP, and PPIB genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI. PMID: 26634552
    8. Over-expression of CypB enhances HIV infection by increasing nuclear import of viral DNA. PMID: 26774171
    9. Cyclophilin B has a high diagnostic value for stomach cancer and its downregulation can effectively inhibit the growth of stomach cancer cells. Thus, cyclophilin B may be a potential therapeutic target for stomach cancer treatment PMID: 26125731
    10. The extracellular portion of cyclophilin B probably plays an important role in human diseases associated with acute or chronic inflammation PMID: 24713575
    11. Findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia. PMID: 24270407
    12. These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis PMID: 24990953
    13. Cyclophilin B is a novel MDM2 interacting partner. PMID: 24583282
    14. cyclophilin B (CypB) is a prolyl isomerase residing in the endoplasmic reticulum (ER), that provides an essential survival signal in glioblastoma multiforme cells through myc and mutant p53 PMID: 24272483
    15. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. PMID: 24043621
    16. Cyclophilin B activity regulated secretion and activity of ADAMTS13. PMID: 23144461
    17. CypB has an essential function in protecting hepatoma cells against oxidative stress through binding to CD147 and regulating the ERK pathway PMID: 22555451
    18. these findings suggest an unexpected role for cyclophilin B in attenuation of the responses of proinflammatory macrophages PMID: 22798670
    19. CypB interacts with these proteins and is involved in ribosome biogenesis and RNA transcription. PMID: 22426501
    20. Cyclophilin B is a candidate pancreatic cancer biomarker. PMID: 22484812
    21. CypB induced by hypoxia stimulates the survival of hepatocellular carcinoma via a positive feedback loop with HIF-1alpha. PMID: 21748762
    22. CAHL is a CsA associated helicase-like protein, which would form trimer complex with cyclophilin B and NS5B of HCV PMID: 21559518
    23. peptidylprolyl cis-trans isomerase B may be required to effectively fold the proline-rich regions of the C-terminal propeptide of procollagen PMID: 21282188
    24. cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity. PMID: 21257749
    25. These results suggest that CypB plays a crucial role in the replication of Japanese encephalitis virus through an interaction with NS4A. PMID: 21281954
    26. Data indicate that CypB through its interaction with Na/K-beta1 might regulate maturation and trafficking of the pump through the secretory pathway. PMID: 21085665
    27. Results reveal the P-domain functions as a unique protein-protein interaction domain and implicate a peptidyl prolyl isomerase as a new element in the calnexin cycle. PMID: 20801878
    28. Cyclophilin B significantly modulate prolactin-induced function in breast cancer cells, ultimately resulting in enhanced levels of prolactin-responsive gene expression, cell growth, and migration. PMID: 20237142
    29. a regulatory mechanism in which cell type-specific expression of certain heparan sulfate sulfotransferases determines the specific binding of CyPB to target cells PMID: 19940140
    30. calcium signaling through CD147 receptor; induces neutrophil chemotaxis PMID: 11688976
    31. act in the context of t lymphocyte recruitment and function PMID: 11867726
    32. Different regions of CyPB are involved in peripheral blood T-lymphocyte activation and imply an important physiological function for peptidylprolyl isomerase activity. PMID: 11955071
    33. Inhibition of the PT-pore (ANT-1) via up-regulation of cyclophilin D plays a role in tumorigenesis PMID: 14729611
    34. Cyclophilin B plays a critical role in the activation of interferon regulatory factor-3. PMID: 15764595
    35. CYPB is a functional rfegulator of hepacivirus RNA polymerase. PMID: 15989969
    36. results strongly support the hypothesis that 3-O-sulfation of GlcNH2 residues could be a key modification that provides specialized HS structures for CyPB binding to responsive cells PMID: 17588944
    37. Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins. PMID: 18054915
    38. CypB is a new TRPV6 accessory protein with potential involvement in TRPV6 channel activation through its peptidyl-prolyl cis/trans isomerase activity PMID: 18445599
    39. the enhanced expression of CypB in malignant breast epithelium may contribute to the pathogenesis of this disease PMID: 19056847
    40. PPIB mutations cause severe osteogenesis imperfecta PMID: 19781681

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Osteogenesis imperfecta 9 (OI9)
  • 亞細胞定位:
    Virion.
  • 蛋白家族:
    Cyclophilin-type PPIase family, PPIase B subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9255

    OMIM: 123841

    KEGG: hsa:5479

    STRING: 9606.ENSP00000300026

    UniGene: Hs.434937



主站蜘蛛池模板: 天天噜噜噜在线视频| 日韩精品久久久久久免费 | 国产一码二码三码区别| 亚洲欭美日韩颜射在线| 人妻人人做人碰人人添| 日日橹狠狠爱欧美超碰| 亚洲精品综合五月久久小说| 欧美网站免费观看在线| 青青草无码伊人久久| 国产又爽又黄又刺激的视频| 亚洲伊人久久成人综合网| 午夜福利啪啪片| 精品无码人妻一区二区三区不卡| 男人下部进女人下部视频| 国产成人亚洲精品无码蜜芽| 日韩av中文无码影院| 欧美中日韩免费观看网站| 无码人妻丰满熟妇啪啪| 国产精品久久久久久久妇| aaa欧美色吧激情视频| 国产麻传媒精品国产av| 四虎精品成人免费视频| 色婷婷五月综合激情中文字幕 | 性色欲情网站iwww| 亚洲精品成人网线在线播放va| 性av盈盈无码天堂| 国产又a又黄又潮娇喘视频| 精品久久久久久国产| 久热这里只精品99国产6-99re视…| 亚洲精品乱码久久久久久日本麻豆| 高中生粉嫩无套第一次| 国产妇女馒头高清泬20p多| 精品熟人妻一区二区三区四区不卡| 亚洲中文字幕aⅴ无码天堂| 精品伊人久久久大香线蕉下载| 久久中文字幕无码专区| 欧美午夜特黄aaaaaa片| 在阳台上玩弄人妻的乳球| 日本乱人伦aⅴ精品| 久久无码字幕中文久久无码| 亚洲一区二区女搞男|