在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POU3F4 Antibody

  • 中文名稱:
    POU3F4兔多克隆抗體
  • 貨號:
    CSB-PA018399LA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA018399LA01HU diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POU3F4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POU3F4
  • 別名:
    Brain specific homeobox POU domain protein 4 antibody; Brain-4 antibody; Brain-specific homeobox/POU domain protein 4 antibody; BRAIN4 antibody; Brn-4 antibody; BRN4 antibody; class 3 antibody; DFN3 antibody; DFNX2 antibody; Oct-9 antibody; Octamer-binding protein 9 antibody; Octamer-binding transcription factor 9 antibody; OTF-9 antibody; OTF9 antibody; PO3F4_HUMAN antibody; POU class 3 homeobox 4 antibody; POU domain antibody; POU domain class 3 transcription factor 4 antibody; Pou3f4 antibody; transcription factor 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human POU domain, class 3, transcription factor 4 protein (22-134AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,POU3F4 Antibody (CSB-PA018399LA01HU),的標記方式是Non-conjugated。對于POU3F4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA018399LB01HU POU3F4 Antibody, HRP conjugated ELISA
    FITC CSB-PA018399LC01HU POU3F4 Antibody, FITC conjugated
    Biotin CSB-PA018399LD01HU POU3F4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.
  • 基因功能參考文獻:
    1. POU3F4 mutations can be predicted by incomplete partition type III anomaly by radiological examination of the inner ear. All six of the patients showed mixed hearing loss, but none showed fluctuations in hearing, which may be related to the lack of vestibular aqueduct enlargement at the operculum. PMID: 27577114
    2. Sequencing of the entire POU3F4 gene is recommended in patients with characteristic temporal bone malformations. Results of POU3F4 mutation testing are important not only for a proper genetic counseling, but also for adequate preparation and conduction of a surgical procedure. PMID: 27941975
    3. A nonsense mutation is identified in a family displaying the pedigree consistent with X-linked recessive pattern in POU3F4 gene. PMID: 28051029
    4. POU3F4 mutation in profoundly deaf patients may have poorer prognosis after cochlear implantation, than other types. PMID: 26600195
    5. findings may greatly contribute to the elucidation of the roles of the Oct and Myc proteins in osteoblast direct reprogramming. The results may also lead to establishment of novel regenerative therapy for various bone resorption diseases PMID: 26499074
    6. Audiological, medical, and family histories were collected and family members interviewed to compare hearing thresholds and case histories between cases with mutations in SMPX versus POU3F4. PMID: 24687041
    7. Our data suggest that different POU3F4 mutations might show different recurrence rate in siblings of the incomplete partition type III anomaly especially in East Asian population PMID: 24608376
    8. POU3F4 mutations are associated with X-linked deafness PMID: 25928534
    9. We concluded that the probable presence of the third window effect is not limited to the particular type of POU3F4 mutation. PMID: 23400403
    10. Results show three novel mutations in the POU3F4 gene resulting in profound hearing loss in both humans and mice. PMID: 23606368
    11. Frameshift truncation and extension mutations in the C-terminus of POU3F4 lead to cytoplasmic localization and subsequent proteosomal degradation due to structural aberrations, which cause transcriptional inactivity and thus nonsyndromic hearing loss. PMID: 23076972
    12. Study found no mutations in GJB6 or POU3F4 in nonsyndromic Tibetan Chinese patients with hearing impairment. PMID: 22389666
    13. pou3f4 expression in inner ear might be under the control of distinct regulatory elements that fine-tune the spatio-temporal activity of this gene PMID: 21209840
    14. DNA sequencing of the POU3F4 gene revealed a novel nucleotide variation, c.647G to A. The additional mutation confirms the crucial role of POU3F4 in auditory function. PMID: 21193157
    15. POU3F4 did not contribute to Y linked familial deafness in a Chinese pedigree. PMID: 16229168
    16. evaluation of DFN3 patients with deletions in the POU3F4 locus and detection of carrier female using MLPA. PMID: 20412083
    17. novel mutations in the POU3F4 gene resulting in congenital X-linked deafness DFN3. PMID: 21250553
    18. Data suggest that multiple enhancers control the expression of Pou3f4 in the inner ear and these may contribute to the phenotype observed in DFN3 patients. PMID: 20668882
    19. Results strongly suggest that the deafness in DFN3 patients is largely due to the null function of POU3F4. PMID: 19671658
    20. The phenotype of eight independent females carrying POU3F4 anomalies is defined, and a late-onset hearing loss is found in three patients. PMID: 19930154
    21. model of DFN3 non-syndromic deafness PMID: 12062767
    22. two novel mutations of the POU3F4 gene in X-linked deafness type 3 patients in the Korean population PMID: 19438930
    23. This publication describes mutations in a similar mouse gene. PMID: 9667433

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Deafness, X-linked, 2 (DFNX2)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    POU transcription factor family, Class-3 subfamily
  • 組織特異性:
    Brain specific.
  • 數據庫鏈接:

    HGNC: 9217

    OMIM: 300039

    KEGG: hsa:5456

    STRING: 9606.ENSP00000362296

    UniGene: Hs.2229



主站蜘蛛池模板: 成人做爰高潮片免费视频| 娇妻被黑人粗大高潮白浆| 五月色丁香婷婷网蜜臀av| 未满十八18禁止午夜免费网站| 极品少妇高潮到爽| 亚洲精品国产精品国自产观看| 国产av激情久久无码天堂 | 精品蜜臀久久久久99网站| 欧美老熟妇欲乱高清视频 | 午夜免费啪视频在线观看区| 国产av天堂亚洲国产av天堂| 大地资源网中文第五页| 亚洲国产综合精品 在线 一区 | 亚洲乱码国产乱码精品精大量| 韩国无码av片在线观看| 性按摩无码中文| 亚洲精品无码国产片| 欧美破苞系列二十三| 亚洲日韩日本中文在线| 亚洲欧洲成人a∨在线| 国产精品十八禁在线观看| 婷婷久久香蕉五月综合| 国产精品禁忌a片特黄a片| 国产精品区av| 国产免费久久久久久无码| 在线 亚洲 国产 欧美| 在线天堂资源www| 亚洲熟妇无码av在线播放| 婷婷色香合缴缴情av第三区| 99热这里只有精品国产免费免费| 疯狂三人交性欧美| 国产精品成人免费一区久久羞羞| 久久综合精品国产一区二区三区无码 | 国产在线无码视频一区二区三区| 麻豆妓女爽爽一区二区三| 天天躁日日躁狠狠躁av| 超碰aⅴ人人做人人爽| 欧美人与动性xxxxbbbb | 亚洲日韩精品国产一区二区三区| 国产亚州精品女人久久久久久| 亚洲精品一区国产|