在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POU3F4 Antibody, HRP conjugated

  • 中文名稱:
    POU3F4兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA018399LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POU3F4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POU3F4
  • 別名:
    Brain specific homeobox POU domain protein 4 antibody; Brain-4 antibody; Brain-specific homeobox/POU domain protein 4 antibody; BRAIN4 antibody; Brn-4 antibody; BRN4 antibody; class 3 antibody; DFN3 antibody; DFNX2 antibody; Oct-9 antibody; Octamer-binding protein 9 antibody; Octamer-binding transcription factor 9 antibody; OTF-9 antibody; OTF9 antibody; PO3F4_HUMAN antibody; POU class 3 homeobox 4 antibody; POU domain antibody; POU domain class 3 transcription factor 4 antibody; Pou3f4 antibody; transcription factor 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human POU domain, class 3, transcription factor 4 protein (22-134AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.
  • 基因功能參考文獻:
    1. POU3F4 mutations can be predicted by incomplete partition type III anomaly by radiological examination of the inner ear. All six of the patients showed mixed hearing loss, but none showed fluctuations in hearing, which may be related to the lack of vestibular aqueduct enlargement at the operculum. PMID: 27577114
    2. Sequencing of the entire POU3F4 gene is recommended in patients with characteristic temporal bone malformations. Results of POU3F4 mutation testing are important not only for a proper genetic counseling, but also for adequate preparation and conduction of a surgical procedure. PMID: 27941975
    3. A nonsense mutation is identified in a family displaying the pedigree consistent with X-linked recessive pattern in POU3F4 gene. PMID: 28051029
    4. POU3F4 mutation in profoundly deaf patients may have poorer prognosis after cochlear implantation, than other types. PMID: 26600195
    5. findings may greatly contribute to the elucidation of the roles of the Oct and Myc proteins in osteoblast direct reprogramming. The results may also lead to establishment of novel regenerative therapy for various bone resorption diseases PMID: 26499074
    6. Audiological, medical, and family histories were collected and family members interviewed to compare hearing thresholds and case histories between cases with mutations in SMPX versus POU3F4. PMID: 24687041
    7. Our data suggest that different POU3F4 mutations might show different recurrence rate in siblings of the incomplete partition type III anomaly especially in East Asian population PMID: 24608376
    8. POU3F4 mutations are associated with X-linked deafness PMID: 25928534
    9. We concluded that the probable presence of the third window effect is not limited to the particular type of POU3F4 mutation. PMID: 23400403
    10. Results show three novel mutations in the POU3F4 gene resulting in profound hearing loss in both humans and mice. PMID: 23606368
    11. Frameshift truncation and extension mutations in the C-terminus of POU3F4 lead to cytoplasmic localization and subsequent proteosomal degradation due to structural aberrations, which cause transcriptional inactivity and thus nonsyndromic hearing loss. PMID: 23076972
    12. Study found no mutations in GJB6 or POU3F4 in nonsyndromic Tibetan Chinese patients with hearing impairment. PMID: 22389666
    13. pou3f4 expression in inner ear might be under the control of distinct regulatory elements that fine-tune the spatio-temporal activity of this gene PMID: 21209840
    14. DNA sequencing of the POU3F4 gene revealed a novel nucleotide variation, c.647G to A. The additional mutation confirms the crucial role of POU3F4 in auditory function. PMID: 21193157
    15. POU3F4 did not contribute to Y linked familial deafness in a Chinese pedigree. PMID: 16229168
    16. evaluation of DFN3 patients with deletions in the POU3F4 locus and detection of carrier female using MLPA. PMID: 20412083
    17. novel mutations in the POU3F4 gene resulting in congenital X-linked deafness DFN3. PMID: 21250553
    18. Data suggest that multiple enhancers control the expression of Pou3f4 in the inner ear and these may contribute to the phenotype observed in DFN3 patients. PMID: 20668882
    19. Results strongly suggest that the deafness in DFN3 patients is largely due to the null function of POU3F4. PMID: 19671658
    20. The phenotype of eight independent females carrying POU3F4 anomalies is defined, and a late-onset hearing loss is found in three patients. PMID: 19930154
    21. model of DFN3 non-syndromic deafness PMID: 12062767
    22. two novel mutations of the POU3F4 gene in X-linked deafness type 3 patients in the Korean population PMID: 19438930
    23. This publication describes mutations in a similar mouse gene. PMID: 9667433

    顯示更多

    收起更多

  • 相關疾病:
    Deafness, X-linked, 2 (DFNX2)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    POU transcription factor family, Class-3 subfamily
  • 組織特異性:
    Brain specific.
  • 數據庫鏈接:

    HGNC: 9217

    OMIM: 300039

    KEGG: hsa:5456

    STRING: 9606.ENSP00000362296

    UniGene: Hs.2229



主站蜘蛛池模板: 国产又色又刺激高潮视频| 四虎成人永久在线精品免费| 大桥久未无码吹潮在线观看 | 免费观看又色又爽又黄的韩国 | 日本又黄又爽又色又刺激的视频| 国产成久久免费精品av片| 亚洲小说图区综合在线| 久久人妻无码一区二区| 无码国内精品人妻少妇蜜桃视频| 日韩国产人妻一区二区三区| 亚洲hdmi高清线| 伊人精品无码av一区二区三区| 国产亚洲tv在线观看| 亚洲色欲www综合网| 国产农村乱对白刺激视频| 天天综合网网欲色| 国产freexxxx性播放麻豆| 亚洲国产a∨无码中文777| 欧美人与动性xxxxbbbb| 免费国产午夜视频在线| 久久综合久久爱久久综合伊人| 蜜色欲多人av久久无码| 久久久久青草线综合超碰| 国产成人+亚洲欧洲+综合| 麻豆久久久9性大片| 亚洲第一av网站| 五月婷婷久久草丁香| 久久www免费人成_看片老司机| 女人与公拘交酡全过程| 欧美肥老太牲交| 午夜无码片在线观看影院y| 久久和欧洲码一码二码三码| 国产在线高清亚洲精品二区| 日本十八禁黄无遮禁视频免费| 亚洲欧洲自拍拍偷精品 美利坚| 特黄做受又硬又粗又大视频小说| 宅男66lu国产在线观看| 欧美亚洲日韩国产综合电影| 忘忧草日本在线www| 女人被躁到高潮免费视频| 新版天堂资源中文www连接|