在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POLM Antibody

  • 中文名稱:
    POLM兔多克隆抗體
  • 貨號(hào):
    CSB-PA018319GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    POLM
  • 別名:
    DNA-directed DNA polymerase mu antibody; DNA-directed DNA/RNA polymerase mu antibody; DPOLM_HUMAN antibody; FLJ35482 antibody; Pol iota antibody; Pol Mu antibody; Polm antibody; POLM protein antibody; Polymerase (DNA directed) mu antibody; Polymerase DNA directed mu antibody; Tdt N antibody; Tdt-N antibody; TdtN antibody; Terminal transferase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human POLM
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
  • 基因功能參考文獻(xiàn):
    1. Polmu point mutations affecting 2 conserved adjacent residues located in the 8 kDa domain, G174S and R175H, limit the efficiency of accurate NHEJ by Polmu in vitro and in vivo due to decreased template dependency during NHEJ, which renders the error-rate of the mutants higher due to the ability of Polmu to randomly incorporate nucleotides at DSBs. PMID: 28973441
    2. Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu has been described. PMID: 28911097
    3. analysis of template-dependent synthesis by human polymerase mu PMID: 26240373
    4. A study of how Polmu fixes and/or orients the mobile Loop1 part of the protein in accordance with the substrate on which it is polymerizing. PMID: 24878922
    5. specific loop 1 residues contribute to Pol mu's unique ability to catalyze template-dependent NHEJ of DSBs with unpaired 3' ends PMID: 24487959
    6. evidence suggests that Polmu could be regulated in vivo by phosphorylation of the BRCT domain (Ser12/Thr21) and of Ser372, affecting the function of loop1; Polmu's most distinctive activities would be turned off at specific cell-cycle phases (S and G2), when these functions might be harmful to the cell PMID: 23933132
    7. A specific N-terminal extension of the 8 kDa domain of DNA polymerase mu is potentially implicated in the maintenance of a closed conformation throughout the catalytic cycle, and this study indicated that it could be a target of Cdk phosphorylation. PMID: 23935073
    8. A physiological concentration of Mn(2+) ions did benefit Polmicro-mediated non-homologous end joining by improving the efficiency and accuracy of nucleotide insertion. PMID: 23275568
    9. The study points at human Polmicro residues His(329) and Arg(387) as responsible for regulating nucleotide expansions occurring during DNA repair transactions, either promoting or blocking, respectively, iterative polymerization. PMID: 23143108
    10. The results uncovered a new DNA-binding function for the BRCT domain of Polmicro and demonstrated the importance of several residues located at the primer-binding region, for both DNA-binding and polymerization activities. PMID: 23034807
    11. Pol mu binds to DNA through its amino-terminal and pol beta-like regions. PMID: 22897684
    12. DNA polymerase mu performs DNA synthesis at a AAF lesion PMID: 11972346
    13. Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. PMID: 12077346
    14. DNA polymerase mu acts in response to several types of DNA damage with a lesion bypass mechanism PMID: 12228225
    15. expression in B-cell non-Hodgkin's lymphomas PMID: 12368208
    16. Pol mu's substrate specificity is similar to that of pol beta in most respects but has an approximately 1,000-fold-reduced ability to discriminate against ribonucleotides compared to pol beta PMID: 12640116
    17. human DNA polymerase mu has a template-dependent, sequence-independent nucleotidyl transferase activity PMID: 14581466
    18. Poliota incorporates a C opposite the gamma-HOPdG adduct with nearly the same efficiency as opposite a nonadducted G residue. The subsequent extension step is performed by Polkappa, which efficiently extends from the C incorporated opposite the adduct. PMID: 15199127
    19. DNA polymerase mu has been overexpressed, purified, and its fidelity estimated for incorporation of both deoxynucleotides and ribonucleotides based on pre-steady-state kinetic data under single-turnover conditions. PMID: 15504045
    20. Overexpression of DNA polymerase mu in a Burkitt's lymphoma cell line induced an increase in somatic mutations specifically targeted to G/C residues in immunoglobulin variable genes. PMID: 15520469
    21. Pol mu promotes accuracy during Ig kappa recombination. PMID: 16061182
    22. When the terminal deoxynucleotidyl transferase (TdT) loop1 was deleted, human Polmu lacked TdT activity but improved DNA-binding and DNA template-dependent polymerization. PMID: 16963491
    23. Studies shed light on the mechanism by which a rate-limited terminal transferase activity in Polmu could regulate the balance between accuracy and necessary efficiency, providing some variability during NHEJ. PMID: 19805281

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    DNA polymerase type-X family
  • 組織特異性:
    Expressed in a number of tissues. Abundant in thymus.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9185

    OMIM: 606344

    KEGG: hsa:27434

    STRING: 9606.ENSP00000242248

    UniGene: Hs.596982



主站蜘蛛池模板: 久久久久久九九精品久| 欧美最猛黑人xxxx黑人猛交| 青青草国产精品免费观看| 国产午夜福利精品一区| 国产亚洲精品久久yy50| 亚洲精品国产一区二区| 中文字幕av伊人av无码av| 一区一区三区产品乱码亚洲| 末成年毛片在线播放| 永久免费看啪啪网址入口| 国产欧美久久一区二区| 免费无码成人片| 麻豆熟妇人妻xxxxxx| 国产无遮挡免费真人视频在线观看 | 无卡无码无免费毛片| 亚洲精品蜜桃久久久久久| 国产成人精品免费视频大全五级| 熟女乱牛牛视频在线观看| 天天爽夜夜爽人人爽曰| 爆乳熟妇一区二区三区 | 国产精品真实灌醉女在线播放| 亚洲成l人在线观看线路| 欧美老妇交乱视频在线观看 | 精品成人av一区二区三区| 又粗又大又硬毛片免费看| 丁香五月激情综合国产| 丰满少妇aaaaaa爰片毛片| 在线精品国产一区二区三区| 色婷婷亚洲一区二区综合| 日韩高清在线亚洲专区小说| 女人下面毛多水多视频| 午夜熟女插插xx免费视频| 亚洲国产精品综合久久网各| 免费现黄频在线观看国产| 久久天天躁夜夜躁狠狠躁| 久久99精品久久只有精品 | 高清无码一区二区在线观看吞精| 国产午夜福利在线播放87| 熟妇人妻无乱码中文字幕| 天堂а√在线中文在线| 亚洲成av人在线视猫咪|