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  4. POGLUT1 Antibody

POGLUT1 Antibody

  • 中文名稱：
    POGLUT1兔多克隆抗體
  • 貨號：
    CSB-PA818754LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, PC-3 whole cell lysate, K562 whole cell lysate, 293 whole cell lysate
      All lanes: POGLUT1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47 kDa
      Observed band size: 47 kDa
    • IHC image of CSB-PA818754LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) POGLUT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    POGLUT1
  • 別名：
    C3orf9 antibody; CAP10 like 46 kDa protein antibody; CAP10 like protein, 46 kDa antibody; CAP10-like 46 kDa protein antibody; CLP46 antibody; hCLP46 antibody; hRumi antibody; KDELC family like 1 antibody; KDELCL1 antibody; KTEL (Lys Tyr Glu Leu) containing 1 antibody; KTEL motif containing protein 1 antibody; KTEL motif-containing protein 1 antibody; KTEL1 antibody; KTELC1 antibody; MDS010 antibody; MDSRP antibody; Myelodysplastic syndromes relative protein antibody; O-glucosyltransferase rumi homolog antibody; PGLT1_HUMAN antibody; Poglut1 antibody; protein O glucosyltransferase 1 antibody; Protein O-glucosyltransferase 1 antibody; Protein O-xylosyltransferase antibody; Rumi antibody; x 010 protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein O-glucosyltransferase 1 protein (132-392AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，POGLUT1 Antibody (CSB-PA818754LA01HU)，的標(biāo)記方式是Non-conjugated。對于POGLUT1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA818754LB01HU POGLUT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA818754LC01HU POGLUT1 Antibody, FITC conjugated
    Biotin CSB-PA818754LD01HU POGLUT1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane.
  • 基因功能參考文獻：
    1. Here we report the generation and characterization of an iPSC line (CSCRMi001-A) from a LGMD-2Z patient with missense mutation in POGLUT1 which can be used for in vitro disease modeling. PMID: 29034878
    2. The data suggest that hCLP46(human CAP10-like protein 46 kDa) overexpression in colorectal cancer is associated with higher tumor-node-metastasis stage, lymph node metastasis, and shorter survival time. PMID: 28481732
    3. These findings expand the spectrum of mutations in POGLUT1 and confirm POGLUT1 as the third candidate gene, along with KRT5 and POFUT1, to consider in diagnosis of GGD/DDD. PMID: 27479915
    4. These data suggest that a key pathomechanism for this novel form of muscular dystrophy with POGLUT1 mutation is Notch-dependent loss of satellite cells. PMID: 27807076
    5. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation PMID: 26058784
    6. miR-134 inhibited human endometrial cancer stem cells proliferation and migration by targeting protein O-glucosyltransferase 1 (POGLUT1) expression PMID: 25528443
    7. Mutations in POFUT1, which encodes protein O-fucosyltransferase 1, were reported to be responsible for Dowling-Degos disease. PMID: 24387993
    8. overexpression of hCLP46 inhibited proliferation of 293TRexs and was correlated with increases in cyclin dependent kinase inhibitors p21 and p27, whereas reduced hCLP46 expression moderately increased cell proliferation. PMID: 23692084
    9. lack of hCLP46 results in impaired ligand induced Notch activation in mammalian cell, and hCLP46 regulates the proliferation of U937 cell through CDKI-RB signaling pathway, which may be important for the pathogenesis of leukemia. PMID: 21458412
    10. CLP46 was overexpressed in AML, T-ALL, and leukemic cell lines. Considering that CLP46 has the capability of modifying the Notch pathway, our finding adds weight to the possible importance of Notch signaling in the pathogenesis of AML and T-ALL. PMID: 20143914
    11. Altered C3ORF9 expression in myelodysplastic syndrome was possibly due to different gene regulation in these patients and/or to the increased CD34+ cells. PMID: 19822096

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  • 相關(guān)疾病：
    Dowling-Degos disease 4 (DDD4); Limb-girdle muscular dystrophy 2Z (LGMD2Z)
  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Glycosyltransferase 90 family
  • 組織特異性：
    Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. E
  • 數(shù)據(jù)庫鏈接：

    HGNC: 22954

    OMIM: 615618

    KEGG: hsa:56983

    STRING: 9606.ENSP00000295588

    UniGene: Hs.231750



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