在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POGLUT1 Antibody, FITC conjugated

  • 中文名稱:
    POGLUT1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA818754LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POGLUT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POGLUT1
  • 別名:
    C3orf9 antibody; CAP10 like 46 kDa protein antibody; CAP10 like protein, 46 kDa antibody; CAP10-like 46 kDa protein antibody; CLP46 antibody; hCLP46 antibody; hRumi antibody; KDELC family like 1 antibody; KDELCL1 antibody; KTEL (Lys Tyr Glu Leu) containing 1 antibody; KTEL motif containing protein 1 antibody; KTEL motif-containing protein 1 antibody; KTEL1 antibody; KTELC1 antibody; MDS010 antibody; MDSRP antibody; Myelodysplastic syndromes relative protein antibody; O-glucosyltransferase rumi homolog antibody; PGLT1_HUMAN antibody; Poglut1 antibody; protein O glucosyltransferase 1 antibody; Protein O-glucosyltransferase 1 antibody; Protein O-xylosyltransferase antibody; Rumi antibody; x 010 protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein O-glucosyltransferase 1 protein (132-392AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane.
  • 基因功能參考文獻:
    1. Here we report the generation and characterization of an iPSC line (CSCRMi001-A) from a LGMD-2Z patient with missense mutation in POGLUT1 which can be used for in vitro disease modeling. PMID: 29034878
    2. The data suggest that hCLP46(human CAP10-like protein 46 kDa) overexpression in colorectal cancer is associated with higher tumor-node-metastasis stage, lymph node metastasis, and shorter survival time. PMID: 28481732
    3. These findings expand the spectrum of mutations in POGLUT1 and confirm POGLUT1 as the third candidate gene, along with KRT5 and POFUT1, to consider in diagnosis of GGD/DDD. PMID: 27479915
    4. These data suggest that a key pathomechanism for this novel form of muscular dystrophy with POGLUT1 mutation is Notch-dependent loss of satellite cells. PMID: 27807076
    5. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation PMID: 26058784
    6. miR-134 inhibited human endometrial cancer stem cells proliferation and migration by targeting protein O-glucosyltransferase 1 (POGLUT1) expression PMID: 25528443
    7. Mutations in POFUT1, which encodes protein O-fucosyltransferase 1, were reported to be responsible for Dowling-Degos disease. PMID: 24387993
    8. overexpression of hCLP46 inhibited proliferation of 293TRexs and was correlated with increases in cyclin dependent kinase inhibitors p21 and p27, whereas reduced hCLP46 expression moderately increased cell proliferation. PMID: 23692084
    9. lack of hCLP46 results in impaired ligand induced Notch activation in mammalian cell, and hCLP46 regulates the proliferation of U937 cell through CDKI-RB signaling pathway, which may be important for the pathogenesis of leukemia. PMID: 21458412
    10. CLP46 was overexpressed in AML, T-ALL, and leukemic cell lines. Considering that CLP46 has the capability of modifying the Notch pathway, our finding adds weight to the possible importance of Notch signaling in the pathogenesis of AML and T-ALL. PMID: 20143914
    11. Altered C3ORF9 expression in myelodysplastic syndrome was possibly due to different gene regulation in these patients and/or to the increased CD34+ cells. PMID: 19822096

    顯示更多

    收起更多

  • 相關疾病:
    Dowling-Degos disease 4 (DDD4); Limb-girdle muscular dystrophy 2Z (LGMD2Z)
  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 蛋白家族:
    Glycosyltransferase 90 family
  • 組織特異性:
    Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. E
  • 數據庫鏈接:

    HGNC: 22954

    OMIM: 615618

    KEGG: hsa:56983

    STRING: 9606.ENSP00000295588

    UniGene: Hs.231750



主站蜘蛛池模板: 中文天堂资源在线www| 国产人妻久久精品二区三区| 免费国产成人午夜福利电影| 国产亚洲精品欧洲在线观看| 大地资源中文在线观看官网第二页 | 乱中年女人伦av二区| 亚洲色中文字幕在线播放| 午夜dj在线观看高清在线视频完整版| 久久精品国产99精品国产2021| 人妻熟女一区二区aⅴ林晓雪| 日韩乱码人妻无码系列中文字幕 | 熟妇高潮精品一区二区三区| 热re99久久精品国99热| 又黄又爽又猛的视频免费| 在线播放十八禁视频无遮挡| 中国凸偷窥xxxx自由视频| 国产狂喷潮在线观看中文| 日日碰狠狠躁久久躁综合小说| 亚洲日韩国产一区二区三区 | 免费视频爱爱太爽了网站| 国精产品999国精产品官网| 国内精品免费久久久久电影院| 成人亚洲a片v一区二区三区蜜臀| 韩国久久久久久级做爰片| 日韩中文无码有码免费视频| 最新亚洲人成网站在线观看| 无码日本精品xxxxxxxxx| 亚洲国产精品一区二区动图| 97色偷偷色噜噜男人的天堂| 新版天堂资源中文8在线| 国产精品毛片va一区二区三区| 少妇精油按摩av无码中字| 亚洲熟女av乱码在线观看漫画| 66亚洲一卡2卡新区成片发布| 97一区二区国产好的精华液| 2021国产精品国产精华| 天天爽夜夜爽人人爽免费| 亚洲国产中文在线二区三区免| 亚洲国产午夜精品理论片在线播放| 丁香五月缴情在线| 野外少妇激情aa 级视频|