在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNPLA1 Antibody

  • 中文名稱:
    PNPLA1兔多克隆抗體
  • 貨號:
    CSB-PA843295LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      All lanes: PNPLA1 antibody at 12μg/ml
      Lane 1: Mouse spleen tissue
      Lane 2: Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58, 48, 49 kDa
      Observed band size: 58 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA843295LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA843295LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA843295LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PNPLA1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PNPLA1
  • 別名:
    PNPLA1 antibody; Patatin-like phospholipase domain-containing protein 1 antibody; EC 3.1.1.- antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Patatin-like phospholipase domain-containing protein 1 protein (101-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PNPLA1 Antibody (CSB-PA843295LA01HU),的標記方式是Non-conjugated。對于PNPLA1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA843295LB01HU PNPLA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA843295LC01HU PNPLA1 Antibody, FITC conjugated
    Biotin CSB-PA843295LD01HU PNPLA1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation. Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide. Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function. These lipids also play a role in keratinocyte differentiation. May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS).
  • 基因功能參考文獻:
    1. We report two novel PNPLA1 mutations including one novel missense mutation c.335C > A (p.Ser112Tyr) and one novel deletion mutation c.733_735delTAC (p.Tyr245del) in Turkish autosomal recessive congenital ichthyosis patients from unrelated consanguineous families. PMID: 29624231
    2. PNPLA1 catalyses the omega-O-esterification with linoleic acid to form acylceramides. PMID: 28248300
    3. PNPLA1 is directly involved in acylceramide synthesis as a transacylase. PMID: 28248318
    4. The PNPLA1 mutations reportedhere show PNPLA1 to be an important, if relatively rare, cause of ARCI. PMID: 28403545
    5. The results show potential phenotypic variation in a small percentage of patients with PNPLA1 mutations. The variability of the clinical manifestations and the lack of typical clinical features are specific for patients with PNPLA1 mutations. PMID: 28093717
    6. Data support that PNPLA1/Pnpla1 is a key player in the formation of omega-O-acylceramide, a crucial process for the epidermal permeability barrier function. PMID: 28369476
    7. analysis of distinct and previously unreported mutations in the PNPLA1 gene in nine extended consanguineous families with autosomal recessive congenital ichthyosis PMID: 27884779
    8. an essential role of PNPLA1 in the synthesis of omega-O-AcylCers in human and murine skin. PMID: 27751867
    9. the variant identified will expand the spectrum of mutations in the PNPLA1 gene, provides more evidence for lack of genotype-phenotype correlation and clinical variability in PNPLA1 and underscores its role in causing autosomal recessive congenital ichthyosis PMID: 26691440
    10. Letter: novel missense PNPLA1 variant causing autosomal recessive congenital ichthyosis in a Pakistani family. PMID: 26778108
    11. Results show that PNPLA1 missense mutations observed in this European family affect the patanin-like domain PMID: 24344921
    12. These results identified hPNPLA1 and a mutant in HeLa cells. PMID: 24057234
    13. One missense and one nonsense mutation in the catalytic domain of human PNPLA1 were found in six individuals with autosomal recessive congenital ichthyoses from two families. PMID: 22246504
    14. PNPLA1 exhibited a modest effect on obesity PMID: 19390624
    15. Observational study of gene-disease association. (HuGE Navigator) PMID: 19390624
    16. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 18414634

    顯示更多

    收起更多

  • 相關疾病:
    Ichthyosis, congenital, autosomal recessive 10 (ARCI10)
  • 亞細胞定位:
    Cytoplasm.
  • 組織特異性:
    Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is
  • 數據庫鏈接:

    HGNC: 21246

    OMIM: 612121

    KEGG: hsa:285848

    STRING: 9606.ENSP00000378072

    UniGene: Hs.407002



主站蜘蛛池模板: 亚洲人成线无码7777| 亚洲a∨国产av综合av| 日韩高清亚洲日韩精品一区| 国产做爰xxxⅹ久久久小说| 亚洲色播永久网址大全| 亚洲丁香五月天缴情综合| 暖暖 在线 日本 免费 中文| 五月丁香六月激情综合在线视频 | 偷拍区清纯另类丝袜美腿| 亚洲无线看天堂av| 亚洲精品一区二区国产精华液| 夫妻免费无码v看片| 97人人模人人爽人人喊网| 亚洲中文字幕无码人在线| 国产片av片永久免费观看| 日本少妇被黑人猛cao| 4438xx亚洲最大五色丁香| 欧美一道本一区二区三区| 国产亚洲精品久久一区二区| 麻豆av一区二区三区| 国产精品无码一区二区三区| 亚洲日本在线在线看片| 太粗太深了太紧太爽了动态图男男| 无码一区二区三区亚洲人妻| 无码专区天天躁天天躁在线| 欧美丰满大乳高跟鞋| 99久久人妻精品免费一区| 久久久久无码精品亚洲日韩| 亚洲国内精品自在线影院| 免费无码久久成人网站入口| 欧美成人一区二免费视频软件| 无码人妻久久一区二区三区不卡| 无码国产片观看| 又白又嫩毛又多15p| 国产精品vⅰdeoxxxx国产| 五月综合色婷婷在线观看 | 国产亚洲精品福利视频| 欧美午夜精品久久久久免费视| 无码中文av有码中文av| 乱人伦视频中文字幕| 免费女人高潮流视频在线观看|