在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PNPLA1 Antibody, FITC conjugated

PNPLA1 Antibody, FITC conjugated

  • 中文名稱：
    PNPLA1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA843295LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PNPLA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PNPLA1
  • 別名：
    PNPLA1 antibody; Patatin-like phospholipase domain-containing protein 1 antibody; EC 3.1.1.- antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Patatin-like phospholipase domain-containing protein 1 protein (101-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation. Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide. Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function. These lipids also play a role in keratinocyte differentiation. May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS).
  • 基因功能參考文獻：
    1. We report two novel PNPLA1 mutations including one novel missense mutation c.335C > A (p.Ser112Tyr) and one novel deletion mutation c.733_735delTAC (p.Tyr245del) in Turkish autosomal recessive congenital ichthyosis patients from unrelated consanguineous families. PMID: 29624231
    2. PNPLA1 catalyses the omega-O-esterification with linoleic acid to form acylceramides. PMID: 28248300
    3. PNPLA1 is directly involved in acylceramide synthesis as a transacylase. PMID: 28248318
    4. The PNPLA1 mutations reportedhere show PNPLA1 to be an important, if relatively rare, cause of ARCI. PMID: 28403545
    5. The results show potential phenotypic variation in a small percentage of patients with PNPLA1 mutations. The variability of the clinical manifestations and the lack of typical clinical features are specific for patients with PNPLA1 mutations. PMID: 28093717
    6. Data support that PNPLA1/Pnpla1 is a key player in the formation of omega-O-acylceramide, a crucial process for the epidermal permeability barrier function. PMID: 28369476
    7. analysis of distinct and previously unreported mutations in the PNPLA1 gene in nine extended consanguineous families with autosomal recessive congenital ichthyosis PMID: 27884779
    8. an essential role of PNPLA1 in the synthesis of omega-O-AcylCers in human and murine skin. PMID: 27751867
    9. the variant identified will expand the spectrum of mutations in the PNPLA1 gene, provides more evidence for lack of genotype-phenotype correlation and clinical variability in PNPLA1 and underscores its role in causing autosomal recessive congenital ichthyosis PMID: 26691440
    10. Letter: novel missense PNPLA1 variant causing autosomal recessive congenital ichthyosis in a Pakistani family. PMID: 26778108
    11. Results show that PNPLA1 missense mutations observed in this European family affect the patanin-like domain PMID: 24344921
    12. These results identified hPNPLA1 and a mutant in HeLa cells. PMID: 24057234
    13. One missense and one nonsense mutation in the catalytic domain of human PNPLA1 were found in six individuals with autosomal recessive congenital ichthyoses from two families. PMID: 22246504
    14. PNPLA1 exhibited a modest effect on obesity PMID: 19390624
    15. Observational study of gene-disease association. (HuGE Navigator) PMID: 19390624
    16. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 18414634

    顯示更多

    收起更多

  • 相關疾病：
    Ichthyosis, congenital, autosomal recessive 10 (ARCI10)
  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is
  • 數據庫鏈接：

    HGNC: 21246

    OMIM: 612121

    KEGG: hsa:285848

    STRING: 9606.ENSP00000378072

    UniGene: Hs.407002



主站蜘蛛池模板： 在线观看无码不卡av中文| 国产成人一区二区三区| 99国产精品国产精品九九 | 好了av四色综合无码久久| 高潮内射双龙视频| 无码国模国产在线观看| 九九久久精品国产av片国产| 少妇与黑人一二三区无码| 国产精品美脚玉足脚交| 动漫精品中文无码卡通动漫| 国产av丝袜旗袍无码网站 | 国产熟妇高潮呻吟喷水| 亚洲成a人片在线播放| 欧美40老熟妇色xxxxx| 欧美深度肠交惨叫| 亚洲男人的天堂网站| 午夜福利影院私人爽爽| 2021久久最新国产精品| 无套内谢的新婚少妇国语播放 | 亚洲中文字幕久在线| 亚洲人成手机电影网站| 中字乱码视频| 麻豆精品导航| 国产成人亚洲精品无码电影| 国产精品天干天干在线综合| 制服丝袜另类专区制服| 国内揄拍高清国内精品对白| 成人区精品一区二区婷婷| 亚洲图欧洲图自拍另类高清| 欧美大片aaaaa免费观看| 特级无码毛片免费视频| 精品久久欧美熟妇www| 国产精品久久精品第一页| 国产男女猛烈无遮挡免费网站| 婷婷色香合缴缴情av第三区| 日日大香人伊一本线久| 麻豆传传媒久久久爱| 强插女教师av在线| 中文字幕人妻丝袜二区| 亚洲经典三级| 亚洲伊人久久大香线蕉|