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PLXNA4 Antibody

  • 中文名稱:
    PLXNA4兔多克隆抗體
  • 貨號:
    CSB-PA226742
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA226742(PLXNA4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA226742(PLXNA4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PLXNA4
  • 別名:
    FAYV2820 antibody; KIAA1550 antibody; PLEXA4 antibody; Plexin-A4 antibody; PlexinA4 antibody; PLXA4_HUMAN antibody; plxna4 antibody; PLXNA4A antibody; PLXNA4B antibody; PRO34003 antibody; UNQ2820/PRO34003 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human PLXNA4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
  • 基因功能參考文獻(xiàn):
    1. Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD. PMID: 27378688
    2. There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4. PMID: 25043464
    3. Rare variants in PLXNA4 and Parkinson's disease. PMID: 24244438
    4. Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. PMID: 21832283
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Plexin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9102

    OMIM: 604280

    KEGG: hsa:91584

    STRING: 9606.ENSP00000323194

    UniGene: Hs.511454



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