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  4. PLXNA4 Antibody, Biotin conjugated

PLXNA4 Antibody, Biotin conjugated

  • 中文名稱：
    PLXNA4兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA862071LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLXNA4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PLXNA4
  • 別名：
    FAYV2820 antibody; KIAA1550 antibody; PLEXA4 antibody; Plexin-A4 antibody; PlexinA4 antibody; PLXA4_HUMAN antibody; plxna4 antibody; PLXNA4A antibody; PLXNA4B antibody; PRO34003 antibody; UNQ2820/PRO34003 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Plexin-A4 protein (24-522AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
  • 基因功能參考文獻：
    1. Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD. PMID: 27378688
    2. There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4. PMID: 25043464
    3. Rare variants in PLXNA4 and Parkinson's disease. PMID: 24244438
    4. Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. PMID: 21832283
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Plexin family
  • 數據庫鏈接：

    HGNC: 9102

    OMIM: 604280

    KEGG: hsa:91584

    STRING: 9606.ENSP00000323194

    UniGene: Hs.511454



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