在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PLIN5 Antibody

PLIN5 Antibody

  • 中文名稱：
    PLIN5兔多克隆抗體
  • 貨號：
    CSB-PA804867LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF7 whole cell lysate, 293 whole cell lysate, Mouse Brain tissue lysate
      All lanes: PLIN5 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51, 55 kDa
      Observed band size: 55 , 20, 25kDa
    • IHC image of CSB-PA804867LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA804867LA01HU diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA804867LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

產品詳情

  • 產品描述：

    The PLIN5 polyclonal antibody is inducibly produced in the rabbit immunized with the recombinant human PLIN5 (305-453aa). It exists as the IgG isotype and liquid form. And it is purified by protein G affinity chromatography and reaches up to 95% in purity. This PLIN5 antibody can react with human- and mouse-origin PLIN5 proteins. It can recognize and detect the PLIN5 protein in three applications, including ELISA, WB, and IF.

    Its target protein PLIN5, also known as OXPAT, mainly regulates lipid metabolism, particularly fatty acid oxidation, in different tissues. Its role in energy metabolism and glucose homeostasis suggests that PLIN5 may have important implications for metabolic diseases, such as obesity, diabetes, and cardiovascular disease.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLIN5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Lipid storage droplet protein 5 antibody; LSDA5 antibody; MLDP antibody; OXPAT antibody; Perilipin 5 antibody; Perilipin-5 antibody; PLIN5 antibody; PLIN5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Synthesized peptide derived from human PLIN5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PLIN5 Antibody (CSB-PA804867LA01HU)，的標記方式是Non-conjugated。對于PLIN5 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA804867LB01HU PLIN5 Antibody, HRP conjugated ELISA
    FITC CSB-PA804867LC01HU PLIN5 Antibody, FITC conjugated
    Biotin CSB-PA804867LD01HU PLIN5 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen?affinity?purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:3000
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
  • 基因功能參考文獻：
    1. The data highlight a key role of PLIN5 in lipid droplets function, first by finely adjusting lipid droplets fatty acids supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle. PMID: 27922115
    2. Notch1 expression is reduced and glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients. PMID: 27428080
    3. High oxygen consumption in middle-aged men was reflected in higher perilipin 5 expression in skeletal muscle. PMID: 26447519
    4. PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle. PMID: 25054327
    5. Perilipin 5 as a lipid droplet protein adapted to mitochondrial energy utilization PMID: 24535284
    6. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5 PMID: 23129790
    7. PLIN5 likely plays an important role in intramyocellular lipid accumulation and oxidation, both of which increase with endurance training in human skeletal muscle. PMID: 22667335
    8. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. PMID: 22127648
    9. Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review] PMID: 21632259
    10. interaction of ATGL with CGI-58 increased lipolysis, whereas interaction of ATGL with perilipin 5 decreased lipolysis. PMID: 21393244
    11. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. PMID: 19602560

    顯示更多

    收起更多

  • 亞細胞定位：
    Lipid droplet. Cytoplasm. Mitochondrion.
  • 蛋白家族：
    Perilipin family
  • 組織特異性：
    Expressed in skeletal muscle, liver, heart and kidney.
  • 數據庫鏈接：

    HGNC: 33196

    OMIM: 613248

    KEGG: hsa:440503

    STRING: 9606.ENSP00000371272

    UniGene: Hs.131034



主站蜘蛛池模板： 国产在线国偷精品产拍| 国产日韩精品视频无码 | 国产成人精品久久一区二区三区 | 欧美性色黄大片www喷水| 国内精品自在自线视频| 免费人成视频19674不收费| 亚洲一区精品无码| 亚洲精品1卡2卡三卡4卡乱码| 潮喷大喷水系列无码久久精品| 国产性色αv视频免费| 国产精品www夜色视频| 亚洲午夜无码久久久久蜜臀av| 国内精品久久久久影院优| 免费人成在线观看网站| 人妻奶水人妻系列| 一本久道久久综合狠狠老| 在线精品亚洲第一区焦香| 色婷婷亚洲一区二区三区| 伦伦影院午夜理论片| 色婷婷久久综合中文久久一本| 天天综合网久久综合免费人成| 亚洲熟女av综合网五月| 成人免费777777被爆出| 18禁无遮挡无码网站免费| 高潮射精日本韩国在线播放| 欧美日本韩国亚洲| 亚洲午夜性猛春交xxxx| 亚洲 欧美 自拍 美腿 卡通| 国产亚洲精品第一综合麻豆| 五月花成人网| 人妻巨大乳挤奶水hd免费看| 婷婷成人五月综合激情| 97精品国产一区二区三区| 国产日产欧产精品| 亚洲狠狠爱综合影院网页| 麻豆国产一区二区三区四区| 荫蒂添的好舒服视频囗交| 日本熟妇人妻xxxxx-欢迎您| 亚洲色www成人永久网址| 国产肥白大熟妇bbbb| 一边啪啪的一边呻吟声口述|