在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PLEKHG5 Antibody

PLEKHG5 Antibody

  • 中文名稱：
    PLEKHG5兔多克隆抗體
  • 貨號：
    CSB-PA018174GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PLEKHG5
  • 別名：
    PLEKHG5 antibody; KIAA0720 antibody; Pleckstrin homology domain-containing family G member 5 antibody; PH domain-containing family G member 5 antibody; Guanine nucleotide exchange factor 720 antibody; GEF720 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PLEKHG5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts.
  • 基因功能參考文獻：
    1. Results indicate that different mutations in PLEKHG5 lead to clinically diverse outcomes Charcot-Marie-Tooth disease or lower motor neuron disease affecting the function of neurons and glial cells. PMID: 23777631
    2. Recruitment of Syx to the cell membrane, the selective activation of Dia1 signaling, coupled with the suppression of ROCK and actin reorganization, plays a key role in establishing cell polarity during directed cell migration. PMID: 24126053
    3. This study identifies compound heterozygous PLEKHG5 mutations as the cause of recessive intermediate Charcot-Marie-Tooth disease. PMID: 23844677
    4. a novel means of regulating junctional Syx localization and function by phosphorylation-induced 14-3-3 binding and further support the importance of Syx function in maintaining stable cell-cell contacts. PMID: 23335514
    5. We identified a homozygous missense mutation (c.1940 T-->C [p.647 Phe-->Ser]) of the Pleckstrin homology domain-containing, family G member 5 gene, PLEKHG5, in families with lower motor neuron disease. PMID: 17564964

    顯示更多

    收起更多

  • 相關疾病：
    Distal spinal muscular atrophy, autosomal recessive, 4 (DSMA4); Charcot-Marie-Tooth disease, recessive, intermediate type, C (CMTRIC)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Cell junction. Cell projection, lamellipodium.
  • 組織特異性：
    Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (G
  • 數據庫鏈接：

    HGNC: 29105

    OMIM: 611067

    KEGG: hsa:57449

    STRING: 9606.ENSP00000366977

    UniGene: Hs.284232



主站蜘蛛池模板： 国产精品亚洲专区无码不卡| 双乳奶水饱满少妇呻吟| 成人动漫综合网| 亚洲一区二区三区av无码| 色欲av永久无码精品无码| 免费不卡无码av在线观看| 欧美噜噜久久久xxx| 亚洲日韩v无码中文字幕| 午夜美女裸体福利视频| 亚洲午夜精品a片一区二区app | 一本色综合网久久| 爽爽午夜影视窝窝看片| 国产97色在线 | 欧洲| 欧美性白人极品hd| 色婷婷综合久久久久中文一区二区| 国产av毛片亚洲含羞草社| 国产精品一区二区高清在线| 凹凸国产熟女精品视频app| 狠狠综合亚洲综合亚洲色| 爆乳一区二区三区无码| 少妇人妻丰满做爰xxx| 久久久婷婷五月亚洲97号色| 久久精品亚洲国产av老鸭网| 久视频精品线在线观看| 国产午夜福利短视频| 久久青青草原国产免费播放| 精品无码一区在线观看| 亚洲精品午夜国产va久久成人| 亚洲va欧美va天堂v国产综合| 麻豆国产成人av在线播放| 伊人久久综合无码成人网| 99久久久无码国产精品6| 国产一区二区野外| 亚洲成a∧人片在线播放无码| 日韩av无码免费播放| 国产免费无码一区二区| 国产亚洲精品福利视频| 亚洲女同一区二区| 香蕉午夜福利院| 国产交换配乱婬视频偷网站| 国产成人a∨激情视频厨房|