在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PLA2G16 Antibody, HRP conjugated

PLA2G16 Antibody, HRP conjugated

  • 中文名稱：
    PLA2G16兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA018089HB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PLA2G16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PLAAT3; HRASLS3; HREV107; PLA2G16; Phospholipase A and acyltransferase 3; Adipose-specific phospholipase A2; AdPLA; Group XVI phospholipase A1/A2; H-rev 107 protein homolog; H-REV107; HREV107-1; HRAS-like suppressor 1; HRAS-like suppressor 3; HRSL3; HREV107-3; Renal carcinoma antigen NY-REN-65
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human HRAS-like suppressor 3 protein (1-132AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity. Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity.; (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm. May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection. Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome. May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery. The lipid-modifying enzyme activity is required for this process.
  • 基因功能參考文獻(xiàn)：
    1. study uncovers two competing processes triggered by Picornaviridae virus entry: activation of a pore-activated clearance pathway and recruitment of a PLA2G16 phospholipase to enable genome release PMID: 28077878
    2. Demonstrate increased PLA2G16 expression activates the MAPK pathway to enhance osteosarcoma metastasis. PMID: 26933804
    3. our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity. PMID: 26381418
    4. Results show that osteosarcoma patients with metastasis showed higher expression of PLA2G16 at both the mRNA and protein levels and shorter overall survival suggesting it as significant prognostic factor for poor outcome. PMID: 25993412
    5. suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3 PMID: 26018079
    6. the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death. PMID: 25871522
    7. crystal structure of the HRASLS3-LRAT chimeric enzyme in a thioester catalytic intermediate state revealed a major structural rearrangement accompanied by three-dimensional domain swapping dimerization not observed in native HRASLS PMID: 25383759
    8. several mutant p53 proteins bind the Pla2g16 promoter at E26 transformation-specific (ETS) binding motifs and knockdown of ETS2 suppressed mutant p53 induction of Pla2g16. PMID: 25024203
    9. Our study further suggests that the PLA/AT activity of H-rev107 may play an important role in H-rev107-mediated RAS suppression. PMID: 24884338
    10. an alternate mechanism for AdPLA in promoting adipose tissue lipolysis that is not contingent on the release of arachidonic acid and that is compatible with its combined PLA(1)/A(2) activity PMID: 22923616
    11. Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT. PMID: 22605381
    12. role of PKC isoenzymes in PP2A and HRSL3(H-REV107-1) tumor suppressor-dependent cell death induction in ovarian carcinoma cell line; verified contribution to PP2A- and HRLS3-dependent apoptosis for PKCzeta suggesting a proapoptotic function of this kinase PMID: 20501645
    13. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. PMID: 19136964
    14. Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA) PMID: 18614531
    15. Contact inhibition of growth and growth arrest caused by histone deacetylase inhibitors probably use the same mechanism to stimulate H-rev107 expression via histone acetylation in NIH3T3 cells PMID: 12054741
    16. H-REV107-1 is deficient in its function as a tumor suppressor in non-small cell lung carcinomas. PMID: 17003497

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Peroxisome membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Nucleus envelope. Lysosome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    H-rev107 family
  • 組織特異性：
    Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down-regulated in some ovarian carcinomas and testicular germ cell tumors. Highly expressed
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17825

    OMIM: 613867

    KEGG: hsa:11145

    STRING: 9606.ENSP00000320337

    UniGene: Hs.502775



主站蜘蛛池模板： 永久黄网站免费视频性色| 国产白袜脚足j棉袜在线观看| 亚洲日韩av无码一区二区三区| 亚洲电影天堂av2017| 688欧美人禽杂交狂配| 国产一区二区三区在线观看免费| 国产免费午夜a无码v视频| 欧美性白人极品hd| 18禁成年免费无码国产 | 亚洲成av人在线观看天堂无码| av大片在线无码免费| 国产成人无码a区精油按摩| 色婷婷久久久swag精品| 啪啪后入内射日韩| 极品少妇伦理一区二区| 国产农村妇女毛片精品久久| 在厨房被c到高潮a毛片奶水| 亚洲日韩久热中文字幕| 国产成人亚洲综合色婷婷秒播| 韩国v欧美v亚洲v日本v| www污污污抽搐喷潮com| 东京道一本热中文字幕| 久久精品成人免费观看| 亚洲图片小说激情综合| 亚洲精品中文字幕无码蜜桃| 日本免费视频| 丁香五月激情综合国产| 久久精品国产精品亚洲38| 亚洲成av人片天堂网| 久久妇女高潮喷水多| 国产在线观看无码的免费网站| 亚洲va久久久噜噜噜久久无码 | 亚洲国产成人无码av在线播放| 亚洲精品一区二区三区中文字幕| 女人和拘做爰正片视频| 国产精品成人亚洲777| 亚洲欧洲无码av一区二区三区| 久久国产精品波多野结衣av| 国产精品多p对白交换绿帽| 亚洲国产欧美在线成人app| 亚洲人成网网址在线看|