在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PLA2G16 Antibody

PLA2G16 Antibody

  • 中文名稱：
    PLA2G16兔多克隆抗體
  • 貨號：
    CSB-PA018089HA01HU
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLA2G16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PLAAT3; HRASLS3; HREV107; PLA2G16; Phospholipase A and acyltransferase 3; Adipose-specific phospholipase A2; AdPLA; Group XVI phospholipase A1/A2; H-rev 107 protein homolog; H-REV107; HREV107-1; HRAS-like suppressor 1; HRAS-like suppressor 3; HRSL3; HREV107-3; Renal carcinoma antigen NY-REN-65
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human HRAS-like suppressor 3 protein (1-132AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PLA2G16 Antibody (CSB-PA018089HA01HU)，的標記方式是Non-conjugated。對于PLA2G16 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA018089HB01HU PLA2G16 Antibody, HRP conjugated ELISA
    FITC CSB-PA018089HC01HU PLA2G16 Antibody, FITC conjugated
    Biotin CSB-PA018089HD01HU PLA2G16 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity. Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity.; (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm. May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection. Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome. May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery. The lipid-modifying enzyme activity is required for this process.
  • 基因功能參考文獻：
    1. study uncovers two competing processes triggered by Picornaviridae virus entry: activation of a pore-activated clearance pathway and recruitment of a PLA2G16 phospholipase to enable genome release PMID: 28077878
    2. Demonstrate increased PLA2G16 expression activates the MAPK pathway to enhance osteosarcoma metastasis. PMID: 26933804
    3. our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity. PMID: 26381418
    4. Results show that osteosarcoma patients with metastasis showed higher expression of PLA2G16 at both the mRNA and protein levels and shorter overall survival suggesting it as significant prognostic factor for poor outcome. PMID: 25993412
    5. suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3 PMID: 26018079
    6. the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death. PMID: 25871522
    7. crystal structure of the HRASLS3-LRAT chimeric enzyme in a thioester catalytic intermediate state revealed a major structural rearrangement accompanied by three-dimensional domain swapping dimerization not observed in native HRASLS PMID: 25383759
    8. several mutant p53 proteins bind the Pla2g16 promoter at E26 transformation-specific (ETS) binding motifs and knockdown of ETS2 suppressed mutant p53 induction of Pla2g16. PMID: 25024203
    9. Our study further suggests that the PLA/AT activity of H-rev107 may play an important role in H-rev107-mediated RAS suppression. PMID: 24884338
    10. an alternate mechanism for AdPLA in promoting adipose tissue lipolysis that is not contingent on the release of arachidonic acid and that is compatible with its combined PLA(1)/A(2) activity PMID: 22923616
    11. Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT. PMID: 22605381
    12. role of PKC isoenzymes in PP2A and HRSL3(H-REV107-1) tumor suppressor-dependent cell death induction in ovarian carcinoma cell line; verified contribution to PP2A- and HRLS3-dependent apoptosis for PKCzeta suggesting a proapoptotic function of this kinase PMID: 20501645
    13. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. PMID: 19136964
    14. Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA) PMID: 18614531
    15. Contact inhibition of growth and growth arrest caused by histone deacetylase inhibitors probably use the same mechanism to stimulate H-rev107 expression via histone acetylation in NIH3T3 cells PMID: 12054741
    16. H-REV107-1 is deficient in its function as a tumor suppressor in non-small cell lung carcinomas. PMID: 17003497

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Peroxisome membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Nucleus envelope. Lysosome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    H-rev107 family
  • 組織特異性：
    Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down-regulated in some ovarian carcinomas and testicular germ cell tumors. Highly expressed
  • 數據庫鏈接：

    HGNC: 17825

    OMIM: 613867

    KEGG: hsa:11145

    STRING: 9606.ENSP00000320337

    UniGene: Hs.502775



主站蜘蛛池模板： 国语对白做受xxxxx在| 老熟妇高潮喷了╳╳╳| 十八岁污网站在线观看| 无码人妻精品中文字幕| 97久久国产露脸精品国产| 国产偷国产偷亚洲清高孕妇| а天堂中文在线官网在线 | 韩国精品无码少妇在线观看| 国产精品一区二区av片| 欧美最猛黑人xxxxx猛交| 69精品人人人人| 国产精品亚洲а∨无码播放| 麻豆国产成人av在线播放欲色| 国产麻豆剧果冻传媒白晶晶| 最近2019中文字幕大全第二页| 国产精品高清不卡在线播放| 男女久久久国产一区二区三区| 国产精品久久国产精品99| 国产97在线 | 免费| 久久精品国产第一区二区三区| 精品国产午夜福利精品推荐| 最新高清无码专区| 日本丰满熟妇videossex一| 国精品人妻无码一区免费视频电影| 无遮挡很爽很污很黄的网站| 国产成人精品123区免费视频| 性暴力欧美猛交在线播放| 人人摸人人搞人人透| 国产精品av免费观看| 国产成人免费无码av在线播放| 国产亚洲日本精品无码| 亚洲精品乱码久久久久久v| 亚洲精品动漫免费二区| 国产在线观看免费观看不卡| 亚洲乱妇亚洲乱妇xinglu| 欧美成人在线视频| 亚洲伊人久久大香线蕉| 日本真人边吃奶边做爽电影| 日韩av无码中文无码不卡电影| 亚洲国产一卡2卡3卡4卡5公司 | 四虎永久在线精品免费网址|