在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PKN2 Antibody

PKN2 Antibody

  • 中文名稱：
    PKN2兔多克隆抗體
  • 貨號：
    CSB-PA018075GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Cardiolipin activated protein kinase Pak2 antibody; MGC150606 antibody; MGC71074 antibody; PAK 2 antibody; PAK2 antibody; PKN gamma antibody; PKN2 antibody; PKN2_HUMAN antibody; PRK2 antibody; PRKCL2 antibody; PRO2042 antibody; Protein kinase C like 2 antibody; Protein kinase C related kinase 2 antibody; Protein kinase C-like 2 antibody; Protein kinase N2 antibody; Protein-kinase C-related kinase 2 antibody; Serine/threonine-protein kinase N2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PKN2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis.; (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
  • 基因功能參考文獻：
    1. The expression of PKN2 in colon cancer cells suppresses tumor associated M2 macrophage polarization and tumor growth. PMID: 29368606
    2. PKN2 knockdown in vitro decreased insulin-stimulated glucose uptake, incorporation into glycogen, and oxidation. Thus, PKN2 alters key signaling pathways and transcriptional networks to regulate glucose and lipid metabolism. PMID: 28720584
    3. Helicobacter pylori CagA interacts with PRK2 and inhibits its kinase activity. PMID: 26041307
    4. findings demonstrate that Yersinia enterocolitica rYopM interacts with RSK1 and PRK2 following cell-penetration PMID: 25513777
    5. Regulation of protein kinase C-related protein kinase 2 (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain. PMID: 22511787
    6. these findings suggest that Hsp90 plays a critical role in the regulation of HCV RNA polymerase phosphorylation via the PDK1-PRK2 signaling pathway. PMID: 22490666
    7. Rho binding is essential for PRK2 function and facilitates PRK2 recruitment to junctions. Kinase-dead PRK2 acts as a dominant-negative mutant and prevents apical junction formation. PMID: 20974804
    8. PRK2/PKN2, is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells, required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B. PMID: 17332740
    9. These observations highlight elements of Nef's functional complexity and demonstrate previously unsuspected structural requirements for PAK-2 activation and MHC-1 down-modulation in Nef's flexible N- and C-terminal regions. PMID: 17632197
    10. Little evidence of association was observed between SNPs in PKN2 and type 2 diabetes in African Americans. PMID: 18443202
    11. the last seven amino acid residues at the C-terminus of PRK2 are not required for the activation of the kinase by RhoA in vitro, however, the extreme C-terminal segment is critical for the full activation of PRK2 by RhoA in cells PMID: 18835241

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
  • 組織特異性：
    Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells.
  • 數據庫鏈接：

    HGNC: 9406

    OMIM: 602549

    KEGG: hsa:5586

    STRING: 9606.ENSP00000359552

    UniGene: Hs.440833



主站蜘蛛池模板： 偷拍区清纯另类丝袜美腿| 国产一卡2卡3卡四卡精品app| 麻豆国产av尤物网站尤物| 青青草免费国产线观720| 亚洲熟妇丰满多毛xxxx| 伊人激情av一区二区三区| 羞羞色男人的天堂| 欧美xxxx做受欧美69| 邪恶肉肉全彩色无遮盖| 日韩精品亚洲人成在线观看| 国产午夜视频在线观看| 手机在线看片| 久久精品国产首页027007| 久久久亚洲欧洲日产国码二区| 波多野av一区二区无码| 日韩人妻无码精品久久久不卡| 国产精品亚洲专区无码不卡| 国产精品欧美福利久久| 国产xxxx色视频在线观看| 影视av久久久噜噜噜噜噜三级| 国产精品美女久久久久av爽李琼| 酒店大战丝袜高跟鞋人妻| 九九精品成人免费国产片| 一本久道久久综合久久爱| 欧洲美女黑人粗性暴交| 久久中文字幕人妻熟av女| 人妻少妇邻居少妇好多水在线| 久热这里只有精品99| 无码日韩精品一区二区三区免费| 好了av四色综合无码| 业余 自由 性别 成熟视频 视频 | 中文字幕乱码人妻二区三区| 纯肉无遮挡无码日本动漫| 亚洲va欧美va国产va综合| 国产精品久久久久久久久电影网| 极品嫩模高潮叫床| 日日日日做夜夜夜夜做无码 | 国产成人精品123区免费视频| 亚洲精品乱码久久久久红杏| 久久综合a∨色老头免费观看| 把插八插露脸对白内射|