在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PKN2 Antibody, HRP conjugated

PKN2 Antibody, HRP conjugated

  • 中文名稱：
    PKN2兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA620966LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PKN2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cardiolipin activated protein kinase Pak2 antibody; MGC150606 antibody; MGC71074 antibody; PAK 2 antibody; PAK2 antibody; PKN gamma antibody; PKN2 antibody; PKN2_HUMAN antibody; PRK2 antibody; PRKCL2 antibody; PRO2042 antibody; Protein kinase C like 2 antibody; Protein kinase C related kinase 2 antibody; Protein kinase C-like 2 antibody; Protein kinase N2 antibody; Protein-kinase C-related kinase 2 antibody; Serine/threonine-protein kinase N2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase N2 protein (925-969AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis.; (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
  • 基因功能參考文獻：
    1. The expression of PKN2 in colon cancer cells suppresses tumor associated M2 macrophage polarization and tumor growth. PMID: 29368606
    2. PKN2 knockdown in vitro decreased insulin-stimulated glucose uptake, incorporation into glycogen, and oxidation. Thus, PKN2 alters key signaling pathways and transcriptional networks to regulate glucose and lipid metabolism. PMID: 28720584
    3. Helicobacter pylori CagA interacts with PRK2 and inhibits its kinase activity. PMID: 26041307
    4. findings demonstrate that Yersinia enterocolitica rYopM interacts with RSK1 and PRK2 following cell-penetration PMID: 25513777
    5. Regulation of protein kinase C-related protein kinase 2 (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain. PMID: 22511787
    6. these findings suggest that Hsp90 plays a critical role in the regulation of HCV RNA polymerase phosphorylation via the PDK1-PRK2 signaling pathway. PMID: 22490666
    7. Rho binding is essential for PRK2 function and facilitates PRK2 recruitment to junctions. Kinase-dead PRK2 acts as a dominant-negative mutant and prevents apical junction formation. PMID: 20974804
    8. PRK2/PKN2, is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells, required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B. PMID: 17332740
    9. These observations highlight elements of Nef's functional complexity and demonstrate previously unsuspected structural requirements for PAK-2 activation and MHC-1 down-modulation in Nef's flexible N- and C-terminal regions. PMID: 17632197
    10. Little evidence of association was observed between SNPs in PKN2 and type 2 diabetes in African Americans. PMID: 18443202
    11. the last seven amino acid residues at the C-terminus of PRK2 are not required for the activation of the kinase by RhoA in vitro, however, the extreme C-terminal segment is critical for the full activation of PRK2 by RhoA in cells PMID: 18835241

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
  • 組織特異性：
    Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells.
  • 數據庫鏈接：

    HGNC: 9406

    OMIM: 602549

    KEGG: hsa:5586

    STRING: 9606.ENSP00000359552

    UniGene: Hs.440833



主站蜘蛛池模板： 亚洲色欲色欲大片www无码| 影音先锋中文无码一区| 亚洲欧美中文日韩v在线97| 文中字幕一区二区三区视频播放 | 99久久er这里只有精品18| 国产亚洲人成网站观看| 成年无码a√片在线观看| 成人天堂婷婷青青视频在线观看| 99麻豆久久久国产精品免费| 久久精品香蕉绿巨人登场| 亚洲欲色欲香天天综合网| 久久久久国产精品嫩草影院| 国产精品无码av天天爽播放器| 国内精品久久久久影院中文字幕| 麻豆精品传媒一二三区艾秋| 日日碰狠狠躁久久躁综合小说| 柠檬福利精品视频导航| 久久精品道一区二区三区| 人人超碰人人超级碰国| а√天堂www在线а√天堂视频| 国产免费一区二区三区免费视频 | 少妇一晚三次一区二区三区| 动漫av纯肉无码av在线播放| 99在线精品视频在线观看| 亚洲欧美成人久久一区| 国产综合色在线精品| 色综合久久久久久久久久| 97成人精品国语自产拍| 天堂资源在线官网| 日韩激情无码不卡码| 伊人狠狠色丁香婷婷综合| 国产精品亚洲玖玖玖在线观看| 国模杨依粉嫩蝴蝶150p| 尹人香蕉久久99天天拍久女久| 国产在线精品视频二区| 很黄很色60分钟在线观看| 鲁鲁鲁爽爽爽在线视频观看| 成年片色大黄全免费软件到| 国产成熟女人性满足视频| 国产午夜激无码av毛片不卡| 亚洲欧洲日产国码在线|