在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PI3 Antibody, Biotin conjugated

  • 中文名稱:
    PI3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA017952HD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PI3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PI3
  • 別名:
    Cementoin antibody; ELAF_HUMAN antibody; Elafin antibody; Elafin/Skalp antibody; Elastase Specific Inhibitor antibody; Elastase-specific inhibitor antibody; ES 1 antibody; ESI antibody; Peptidase inhibitor 3 antibody; Peptidase inhibitor 3; skin derived antibody; PI 3 antibody; PI-3 antibody; PI3 antibody; Pre elafin antibody; Protease inhibitor 3 skin derived antibody; Protease inhibitor 3; skin derived (SKALP) antibody; Protease inhibitor WAP3 antibody; SKALP antibody; Skin derived Anti leukoproteinase antibody; Skin-derived antileukoproteinase antibody; Trappin 2 antibody; WAP four disulfide core domain 14 antibody; WAP four disulfide core domain protein 14 antibody; WAP four-disulfide core domain protein 14 antibody; WAP3 antibody; WFDC14 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Elafin protein (61-117AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).
  • 基因功能參考文獻:
    1. Elafin decreased in active patients with inflammatory bowel disease and was negatively correlated with disease activity, suggesting that elafin may play a protective role PMID: 29084078
    2. Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome PMID: 28187039
    3. UV phototoxicity-induced pre-elafin inside keratinocytes prior to cornified envelope formation could be involved in UV-induced keratinocyte apoptosis via cystatin-A downregulation resulting in pro-caspase-3 activation. PMID: 28119996
    4. Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia PMID: 28802561
    5. significantly higher expression in preterm prelabor ruptured fetal membranes than in membranes from term birth PMID: 27580179
    6. Our study revealed that high elafin levels identified in smoking- and asthma-related microarray data sets and an epidemiologic study significantly reduced the risk of asthma. PMID: 26932165
    7. The expression of elafin in fallopian tubes of ectopic pregnancies is reduced. PMID: 25356943
    8. The elevations in cervical elafin and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor. PMID: 25559229
    9. PI3 expression was downregulated in 24% of DCIS and 83% of invasive breast tumors. PI3 was also downregulated in 33% of ovarian cystadenomas, 43% of borderline ovarian tumors, and 86% of invasive ovarian carcinomas. PMID: 25551582
    10. The imbalance between neutrophil elastase and its inhibitors, such as elafin, presents an important therapeutic target in breast cancer. PMID: 25195861
    11. Higher urinary elafin levels are associated with an increased risk of micro- and macroalbuminuria, acute kidney injury and chronic kidney disease, and death after hematopoietic stem cell transplantation. PMID: 25388519
    12. cutaneous elafin does not seem to discriminate acute graft-versus-host disease from drug hypersensitivity rash lesions, but there may be an association between cutaneous elafin expression and poor prognosis for patients with cutaneous GVHD PMID: 25405322
    13. Data indicate that elafin overexpression is associated with poor overall survival. PMID: 24469047
    14. Low expression of elafin gene correlated with significantly reduced time to relapse, and when combined with high expression of elastase gene was associated with decreased survival in breast cancer patients PMID: 23320734
    15. Elafin has important roles in normal homoeostasis and at sites of inflammation. These roles include antiprotease and antimicrobial activity. PMID: 19906197
    16. Results confirm the association between SNP rs2664581 and enhanced risk of developing acute respiratory distress syndrome. PMID: 24617927
    17. Tubal epithelium from women with hydrosalpinx has lower levels of elafin expression. PMID: 23885101
    18. Elafin expression in the small intestinal epithelium was lower in patients with active celiac disease compared with control patients. In vitro, elafin significantly slowed the kinetics of the deamidation of the 33-mer peptide to its more immunogenic form. PMID: 24710505
    19. Production of HBD2 and elafin by vaginal epithelial cells is sensitive to E, suggesting that innate immune protection varies in the vagina across the menstrual cycle. PMID: 23398087
    20. Elafin expression may establish the diagnosis of pre-engraftment syndrome and graft versus host disease. PMID: 23866880
    21. Trappin-2 and elafin significantly reduce HSV-2 viral attachment to, and replication in genital epithelial cells. PMID: 23637403
    22. The N-terminus of elafin is critical for intranuclear localization and anti-HIV-1 activity. PMID: 23300756
    23. Studies indicate that Trappin-2/Elafin possessing anti-microbial properties against different classes of pathogens including viruses, fungi and bacteria. PMID: 22634606
    24. The results suggest that decreased expression of elastin and LOX and increased expression of elafin in the cardinal ligaments may contribute to pelvic organ prolapse. PMID: 19087518
    25. The endometrium of women with hydrosalpinx has an increased number of neutrophils and lower expression of elafin, an elastase inhibitor and natural antimicrobial molecule. PMID: 21392745
    26. these results collectively suggest that, in melanoma cells, Foxa2 expression is silenced and therefore elafin is maintained unexpressed to facilitate cell proliferation in the disease melanoma. PMID: 21466784
    27. ability to modulate the expression of some P.aeruginosa virulence factors PMID: 20932308
    28. These results suggest that elafin can maintain airway epithelium integrity by protecting airway epithelial cells and enhancing the anti-inflammatory capability of airway. PMID: 19823954
    29. increased production at the secretory phase of the menstrual cycle relative to the proliferative phase PMID: 19824918
    30. Elafin has a role in graft-versus-host disease of the skin PMID: 20371463
    31. Elafin may serve as a determinant of poor survival in serous ovarian carcinomas PMID: 20126474
    32. Overexpression of elafin in epithelial cells attenuated the damage of Pseudomonas aeruginosa biofilm. PMID: 19420899
    33. Elafin is a component of cervicovaginal secretions in pregnancy, and levels are diminished in bacterial vaginosis. PMID: 19723838
    34. Synthesized locally at mucosal sites. Efficiently inhibit target enzymes released into interstitium. Might be important in controlling excessive neutrophil elastase release in chronic obstructive pulmonary disease and cystic fibrosis. (review) PMID: 11667971
    35. regulation of the elafin gene is dependent on chromatin structure in keratinocytes PMID: 12542536
    36. results indicate that elafin may have a dual function, promoting up-regulation of local lung innate immunity while simultaneously down-regulating potentially unwanted systemic inflammatory responses in the circulation PMID: 12819058
    37. elafin regulates proteolytic enzymes during menstruation and contributes to the innate defense against uterine infection PMID: 12970320
    38. Serine elastase inhibition (elafin overexpression) appears to suppress inflammation, cardiac dilatation, and dysfunction after myocardial infarct. PMID: 14693682
    39. Gene augmentation of human elafin suggests a novel and extended anti-inflammatory role for this human neutrophil elastase inhibitor working as an effector of innate immunity to protect tissues against maladaptive inflammatory responses. PMID: 15034071
    40. The differential biological activity of elafin in different conditions suggests a role for this molecule in either LPS detoxification or activation of innate immune responses, depending on the external cellular environment. PMID: 15668324
    41. Oxidized elafin poorly inhibits the elastolytic activity of leukocyte elastase and proteinase 3. PMID: 16279952
    42. transglutaminase 2-mediated cross-linking of serine protease inhibitors elafin and trappin-2 to neutrophil serine proteinases preserves their inhibitory capacities PMID: 16300411
    43. The pleiotropic molecule elafin has significant potential in modulating antigen-presenting cell numbers and activity, and could be beneficial in mucosal protective strategies. PMID: 16424380
    44. The promoter sequences of PI3 have a high degree of variability. PMID: 16719916
    45. beneficial effects of pre-elafin could be mediated, at least in part, by its ability to increase G-CSF levels in the lung PMID: 16913840
    46. The transglutaminase substrate moiety of elafin plays an important role in anchoring elafin at its proper sites of action during UV-induced aging processes. PMID: 17139263
    47. Levels of mRNA and immunostaining of the antiproteases elafin and SLPI were enhanced strongly in inflamed versus noninflamed UC. Elafin and SLPI may be added to the list of defensin-like peptides with diminished induction in CD versus UC. PMID: 17200145
    48. full antipeptidase activity of pre-elafin is essential to protect against lung tissue lesions PMID: 17489739
    49. This review focuses on recent findings revealing that elafin has many biological functions as diverse as anti-bacterial, anti-fungal, anti-viral, anti-inflammatory and immuno-modulatory functions. PMID: 17964057
    50. We report here that pre-elafin inhibits a secreted peptidase to prevent Pseudomonas aeruginosa growth in vitro. PMID: 18025118

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 數據庫鏈接:

    HGNC: 8947

    OMIM: 182257

    KEGG: hsa:5266

    STRING: 9606.ENSP00000243924

    UniGene: Hs.112341



主站蜘蛛池模板: 香蕉影院在线观看| 97性无码区免费| 国产亚洲日韩欧美另类丝瓜app| 国产精品免费久久久久电影| 无码人妻aⅴ一区二区三区69岛| 国产精品麻豆欧美日韩ww| 国产亚洲日韩欧美另类第八页| 忘忧草社区中文字幕www| 欧美黑人巨大videos精品男男| 精品国产高清自在线一区二区| 无码中文av波多野结衣一区| 三级特黄60分钟在线播放| 精品人妻少妇一区二区三区不卡| 2021年国产精品专区丝袜| 无码中文字幕va精品影院| 亚洲精品伊人久久久大香| 超薄丝袜足j好爽在线| 日本丰满熟妇videossex8k| 亚洲精品乱码久久久久久蜜桃不卡| 欧美国产激情一区二区在线| 大香网伊人久久综合网2018| 少妇激情一区二区三区视频小说| 人人妻人人藻人人爽欧美一区| 亚洲国产欧美在线人成大黄瓜| 992tv精品视频tv在线观看| 性暴力欧美猛交在线播放| 成年无码av片| 欧洲多毛裸体xxxxx| 国产天美传媒性色av出轨| 久久人妻国产精品31| 亚洲大码熟女在线| 3d动漫精品啪啪一区二区免费| 妺妺窝人体色777777| 蜜臀色欲av在线播放国产日韩| 久久不见久久见www电影免费| 久久精品国产99国产精品澳门 | 久久久久人妻一区精品色| 18禁黄污吃奶免费看网站| 成人亚洲a片v一区二区三区日本 | 国产无遮挡又黄又爽免费网站| 新版天堂资源中文www连接 |