在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PHGDH Antibody

  • 中文名稱:
    PHGDH兔多克隆抗體
  • 貨號:
    CSB-PA794903
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 cells, A431 cells, Primary antibody: CSB-PA794903(PHGDH Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    3 PGDH antibody; 3-PGDH antibody; 3-phosphoglycerate dehydrogenase antibody; 3PGDH antibody; D-3-phosphoglycerate dehydrogenase antibody; EC 1.1.1.95 antibody; Epididymis secretory protein Li 113 antibody; HEL S 113 antibody; NLS antibody; NLS1 antibody; PDG antibody; PGAD antibody; PGD antibody; PGDH antibody; PGDH3 antibody; Phgdh antibody; PHGDHD antibody; Phosphoglycerate dehydrogenase antibody; SERA antibody; SERA_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human PHGDH
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
  • 基因功能參考文獻:
    1. PHGDH expression is regulated by PlncRNA-1 in breast cancer. PMID: 29626321
    2. Study provides evidence that a unique metabolic program is activated in a lung adenocarcinoma subset, described by PHGDH, which confers cell growth. PMID: 28614715
    3. Data indicate that the expression of PHGDH is increased in pancreatic cancer and is an independent molecular prognostic factor for pancreatic cancer patients. In addition, PHGDH controls cell proliferation, migration and invasion abilities. PMID: 29128633
    4. Data show there was a significant negative correlation between PHGDH copy-number alteration and EPAS1 (HIF2A) expression. PMID: 28951458
    5. Therefore, we show for the first time that the nuclear localization of Cat L and its substrate Cux1can be positively regulated by Snail NLS and importin beta1, suggesting that Snail, Cat L and Cux1 all utilize importin beta1 for nuclear import. PMID: 28698143
    6. High PHGDH expression is associated with idiopathic pulmonary fibrosis. PMID: 27836973
    7. This report present 6 individuals from 3 unrelated families with infantile serine biosynthesis defect due to PGDH deficiency. PMID: 28135894
    8. Overexpression of Phgdh may be generally associated with CK5 cells, and oncogenic function may be determined by isoform expression. PMID: 26026368
    9. High expression of PHGDH is associated with Colon Cancer. PMID: 26439504
    10. p53-mediated repression of PHGDH enhances the apoptotic response upon serine starvation in melanoma cells. PMID: 25404730
    11. Phosphoglycerate Dehydrogenase deficiency is associated with Neu-Laxova syndrome. PMID: 25152457
    12. We report on the identification of homozygous mutations in PHGDH and serine deficiency in individuals with Neu-Laxova syndrome. This disorder thus seems to be an extremely severe expression of PHGDH deficiency. PMID: 24836451
    13. PHGDH overexpression is found in cervical cancer, in particular, in bigger tumors and with advanced stages. Its expression is positively correlated with squamous cell carcinoma antigen level PMID: 24247658
    14. The potential mechanisms by which PHGDH promotes cancer are discussed. PMID: 21981974
    15. in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase. PMID: 21804546
    16. results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets PMID: 21760589
    17. Studies in bacteria showed that addition of substrate at the active site is ordered, with HPAP binding before NADH. Also, NADH can compete with the substrate for binding to the allosteric site and thereby eliminate the substrate inhibition. PMID: 19388702
    18. The crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase has been solved with bound effector, 1-serine, and substrate, hydroxypyruvic acid phosphate. The human enzyme was also examined. PMID: 18627175
    19. The frequency of antibodies to Phgdh is much higher in patients with autoimmune hepatitis than in patients with other types of hepatitis or normal controls. PMID: 19497206
    20. PHGDH is expressed in cytoplasm of stromal and glandular cells in endometrium; expression is relatively high in proliferative phase and lower in secretory phase. Data suggest expression of PHGDH in endometrium is regulated by HOXA10. PMID: 19778996
    21. we conclude that this mutation impairs the folding and/or assembly of PHGDH but has minimal effects on the activity or stability of that portion of the V490M mutant that reaches a mature conformation PMID: 11751922
    22. These data suggest that missense mutations associated with 3-PGDH deficiency either primarily affect substrate binding or result in very low residual enzymatic activity. PMID: 19235232
    23. a coding PHGDH SNP (rs543703) was weakly associated with the development of schizophrenia in Korean population PMID: 19404161

    顯示更多

    收起更多

  • 相關疾病:
    Phosphoglycerate dehydrogenase deficiency (PHGDHD); Neu-Laxova syndrome 1 (NLS1)
  • 蛋白家族:
    D-isomer specific 2-hydroxyacid dehydrogenase family
  • 數據庫鏈接:

    HGNC: 8923

    OMIM: 256520

    KEGG: hsa:26227

    STRING: 9606.ENSP00000358417

    UniGene: Hs.487296



主站蜘蛛池模板: 色94色欧美sute亚洲线路一| 国产熟妇高潮呻吟喷水| 免费香蕉成视频人网站| av无码午夜福利一区二区三区| 人妻av综合天堂一区| xx性欧美肥妇精品久久久久久| 18禁黄无遮挡网站免费| 免费无码又爽又刺激软件下载| 国产精品久久久久久tv| 中国免费看的片| 麻豆精品导航| 狠狠色成人综合网| 欧美日韩国产专区一区二区| 色婷婷综合缴情综免费观看| 天堂中文最新版在线中文| 久久久水蜜桃国产成人网站| 亚洲自偷自偷偷色无码中文| 亚洲 小说 欧美 激情 另类 | 中文字幕乱码无码人妻系列蜜桃| 日韩人妻无码精品久久| 国产成人精品无码a区在线观看 | 蜜桃av色偷偷av老熟女| 国产亚洲熟妇在线视频| 国产欧美亚洲日韩图片| 成 人免费va视频| 在线综合亚洲欧美日韩| 少妇高潮惨叫久久久久电影| 日韩电影一区二区三区| www插插插无码视频网站| 秋秋影视午夜福利高清| 久久久免费无码成人影片| 色婷婷av99xx| 黄网站色视频免费国产| 国产福利在线永久视频| 中文无码av一区二区三区| 国产又爽又黄又不遮挡视频| 精品无人乱码高清| 国产裸拍裸体视频在线观看| 免费观看激色视频网站| 色一乱一伦一图一区二区精品| 中文字幕av无码专区第一页|