在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PHGDH Antibody

  • 中文名稱:
    PHGDH兔多克隆抗體
  • 貨號:
    CSB-PA03257A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: PHGDH antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA03257A0Rb at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PHGDH Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    3 PGDH antibody; 3-PGDH antibody; 3-phosphoglycerate dehydrogenase antibody; 3PGDH antibody; D-3-phosphoglycerate dehydrogenase antibody; EC 1.1.1.95 antibody; Epididymis secretory protein Li 113 antibody; HEL S 113 antibody; NLS antibody; NLS1 antibody; PDG antibody; PGAD antibody; PGD antibody; PGDH antibody; PGDH3 antibody; Phgdh antibody; PHGDHD antibody; Phosphoglycerate dehydrogenase antibody; SERA antibody; SERA_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human D-3-phosphoglycerate dehydrogenase protein (2-251AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PHGDH Antibody (CSB-PA03257A0Rb),的標記方式是Non-conjugated。對于PHGDH Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA03257B0Rb PHGDH Antibody, HRP conjugated ELISA
    FITC CSB-PA03257C0Rb PHGDH Antibody, FITC conjugated
    Biotin CSB-PA03257D0Rb PHGDH Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
  • 基因功能參考文獻:
    1. PHGDH expression is regulated by PlncRNA-1 in breast cancer. PMID: 29626321
    2. Study provides evidence that a unique metabolic program is activated in a lung adenocarcinoma subset, described by PHGDH, which confers cell growth. PMID: 28614715
    3. Data indicate that the expression of PHGDH is increased in pancreatic cancer and is an independent molecular prognostic factor for pancreatic cancer patients. In addition, PHGDH controls cell proliferation, migration and invasion abilities. PMID: 29128633
    4. Data show there was a significant negative correlation between PHGDH copy-number alteration and EPAS1 (HIF2A) expression. PMID: 28951458
    5. Therefore, we show for the first time that the nuclear localization of Cat L and its substrate Cux1can be positively regulated by Snail NLS and importin beta1, suggesting that Snail, Cat L and Cux1 all utilize importin beta1 for nuclear import. PMID: 28698143
    6. High PHGDH expression is associated with idiopathic pulmonary fibrosis. PMID: 27836973
    7. This report present 6 individuals from 3 unrelated families with infantile serine biosynthesis defect due to PGDH deficiency. PMID: 28135894
    8. Overexpression of Phgdh may be generally associated with CK5 cells, and oncogenic function may be determined by isoform expression. PMID: 26026368
    9. High expression of PHGDH is associated with Colon Cancer. PMID: 26439504
    10. p53-mediated repression of PHGDH enhances the apoptotic response upon serine starvation in melanoma cells. PMID: 25404730
    11. Phosphoglycerate Dehydrogenase deficiency is associated with Neu-Laxova syndrome. PMID: 25152457
    12. We report on the identification of homozygous mutations in PHGDH and serine deficiency in individuals with Neu-Laxova syndrome. This disorder thus seems to be an extremely severe expression of PHGDH deficiency. PMID: 24836451
    13. PHGDH overexpression is found in cervical cancer, in particular, in bigger tumors and with advanced stages. Its expression is positively correlated with squamous cell carcinoma antigen level PMID: 24247658
    14. The potential mechanisms by which PHGDH promotes cancer are discussed. PMID: 21981974
    15. in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase. PMID: 21804546
    16. results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets PMID: 21760589
    17. Studies in bacteria showed that addition of substrate at the active site is ordered, with HPAP binding before NADH. Also, NADH can compete with the substrate for binding to the allosteric site and thereby eliminate the substrate inhibition. PMID: 19388702
    18. The crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase has been solved with bound effector, 1-serine, and substrate, hydroxypyruvic acid phosphate. The human enzyme was also examined. PMID: 18627175
    19. The frequency of antibodies to Phgdh is much higher in patients with autoimmune hepatitis than in patients with other types of hepatitis or normal controls. PMID: 19497206
    20. PHGDH is expressed in cytoplasm of stromal and glandular cells in endometrium; expression is relatively high in proliferative phase and lower in secretory phase. Data suggest expression of PHGDH in endometrium is regulated by HOXA10. PMID: 19778996
    21. we conclude that this mutation impairs the folding and/or assembly of PHGDH but has minimal effects on the activity or stability of that portion of the V490M mutant that reaches a mature conformation PMID: 11751922
    22. These data suggest that missense mutations associated with 3-PGDH deficiency either primarily affect substrate binding or result in very low residual enzymatic activity. PMID: 19235232
    23. a coding PHGDH SNP (rs543703) was weakly associated with the development of schizophrenia in Korean population PMID: 19404161

    顯示更多

    收起更多

  • 相關疾病:
    Phosphoglycerate dehydrogenase deficiency (PHGDHD); Neu-Laxova syndrome 1 (NLS1)
  • 蛋白家族:
    D-isomer specific 2-hydroxyacid dehydrogenase family
  • 數據庫鏈接:

    HGNC: 8923

    OMIM: 256520

    KEGG: hsa:26227

    STRING: 9606.ENSP00000358417

    UniGene: Hs.487296



主站蜘蛛池模板: 男ji大巴进入女人的视频小说| 免费裸体无遮挡黄网站免费看| 欧美成人精品三级网站| 日韩乱码人妻无码中文字幕视频| 日日碰狠狠躁久久躁96| 无人去码一码二码三码区| 毛片内射久久久一区| 人妻人人做人做人人爱| 国产综合有码无码视频在线| 欧美人妻久久精品| 亚洲熟妇无码爱v在线观看| 亚洲va久久久噜噜噜久久狠狠| 亚洲精品无码av中文字幕电影网站 | 丰满少妇做爰视频爽爽和| 一本大道熟女人妻中文字幕在线| 国产农村乱对白刺激视频| 国产av区男人的天堂| 99c视频色欲在线| 亚洲精品乱码久久久久久金桔影视 | 丰满诱人的人妻3| 亚洲成a人v欧美综合天堂下载 | 东北老女人高潮大叫对白| 色吊丝中文字幕| 亚洲中文字幕久久无码| 亚洲毛片无码不卡av在线播放| 人人妻人人妻人人人人妻人人| 黑人强辱丰满的人妻熟女| 成人免费777777| 亚洲一区二区三区波多野结衣| 日韩好精品视频你懂的| 内射无码专区久久亚洲| 国产精品毛片完整版视频| 亚洲五月综合缴情在线观看| 免费国精产品wnw2544| 51妺嘿嘿午夜福利| 国产三级农村妇女在线| 亚洲男人第一av网站| 国产乱妇无乱码大黄aa片| 国产毛片一区二区精品| 日韩精品 中文字幕 视频在线| 国产精品av免费观看|