在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PHACTR1 Antibody

PHACTR1 Antibody

  • 中文名稱：
    PHACTR1兔多克隆抗體
  • 貨號：
    CSB-PA017880LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Rat brain tissue, Mouse brain tissue
      All lanes: PHACTR1 antibody at 6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 67, 55 kDa
      Observed band size: 67 kDa
    • IHC image of CSB-PA017880LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA017880LA01HU diluted at 1:400 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA017880LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PHACTR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PHACTR1
  • 別名：
    PHACTR1 antibody; KIAA1733 antibody; RPEL1 antibody; Phosphatase and actin regulator 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Phosphatase and actin regulator 1 protein (263-387AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PHACTR1 Antibody (CSB-PA017880LA01HU)，的標記方式是Non-conjugated。對于PHACTR1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017880LB01HU PHACTR1 Antibody, HRP conjugated ELISA
    FITC CSB-PA017880LC01HU PHACTR1 Antibody, FITC conjugated
    Biotin CSB-PA017880LD01HU PHACTR1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization.
  • 基因功能參考文獻：
    1. our study suggests that several PHACTR1 and SLC22A3 gene polymorphisms may exert a protective effect against the CAD in the Chinese Han male population. PMID: 27893421
    2. PHACTR1 is a key atherosclerosis candidate gene since it is regulated by atherogenic stimuli in macrophages and endothelial cells PMID: 27187934
    3. Stimulation of Slack K(+) channels alters mass at the plasma membrane by triggering dissociation of Phactr-1. PMID: 27545877
    4. CRISPR-edited stem cell-derived endothelial cells demonstrate rs9349379, a common SNP in the 3 intron of the PHACTR1 gene, regulates expression of endothelin 1 (EDN1), a gene located 600 kb upstream of PHACTR1. The known physiologic effects of EDN1 on the vasculature may explain the pattern of risk for the five associated vascular diseases. PMID: 28753427
    5. To evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. Results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population. PMID: 27517945
    6. the expression of PHACTR1 by genotypes in primary human fibroblasts showed higher expression in rs9349379-A carriers . Phactr1 knockdown in zebrafish resulted in dilated vessels indicating subtle impaired vascular development PMID: 27792790
    7. There was no significant association between the presence of risk alleles of rs12526453 and coronary heart disease in an Iranian population. PMID: 28287809
    8. our result highlighted the pivotal role of phactr-1 protein in the pathogenesis of atherosclerosis. PMID: 26362351
    9. The rs12526453 CC homozygotes (previously associated with increased risk of myocardial infarction) showed, in 2 independent samples, better long-term survival. PMID: 26086777
    10. GWAS analysis of 1,393 cervical artery dissection cases and 14,416 controls showed that the rs9349379[G] allele was associated with lower risk. This was confirmed independent follow-up samples. PMID: 25420145
    11. a novel signaling route whereby TGF-beta silences the expression of miR-584, resulting in enhanced PHACTR1 expression, and further leading to actin rearrangement and breast cancer cell migration. PMID: 23479725
    12. 3 loci from related cardiovascular genomewide studies were significant: PHACTR1 in large-vessel disease (P=2.63e(-6)), PITX2 in cardioembolic stroke (P=4.78e(-8)), and ZFHX3 in cardioembolic stroke (P=5.50e(-7)). PMID: 23042660
    13. Results from this GWAS support a central role of PHACTR1 in CAD susceptibility irrespective of lifestyle and ethnic divergences. PMID: 22745674
    14. Phactr-1 is a key component in the angiogenic process PMID: 21939755
    15. Findings suggest that PHACTR-1 is likely to be a key regulator of endothelial cell function properties. PMID: 21798305
    16. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20738937
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 20971364
    18. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    19. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19198609

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell junction, synapse. Nucleus.
  • 蛋白家族：
    Phosphatase and actin regulator family
  • 組織特異性：
    Detected in umbilical vein endothelial cells.
  • 數據庫鏈接：

    HGNC: 20990

    OMIM: 608723

    KEGG: hsa:221692

    STRING: 9606.ENSP00000329880

    UniGene: Hs.436996



主站蜘蛛池模板： 亚洲欧洲专线一区| 久久久久国产精品人妻aⅴ果冻 | 无码av高潮抽搐流白浆| 免费久久人人爽人人爽av| 亚洲国产精品特色大片观看完整版| 亚洲一卡2卡3卡4卡 精品| 欧美人成视频在线视频| 日韩在线看片免费人成视频播放| 免费观看美女裸体网站| 亚洲a∨无码一区二区| 久久tv中文字幕首页| 国产成人精品一区二区不卡| 亚洲老熟女av一区二区在线播放| 538在线精品视频| 亚洲人av高清无码| 国产99久久久久久免费看| 99精品国产福利在线观看| 亚洲精品国产自在久久| 香港三级日本三级韩级人妇| 国产边打电话边被躁视频| 美女内射毛片在线看免费人动物| 麻豆国产在线精品国偷产拍| 久久不见久久见免费影院视频| 亚洲精品久久| 成人午夜精品无码区| 欧美xxxx做受欧美1314| 日本japanese丰满多毛| 无码一区二区三区av在线播放| 久久国产欧美日韩精品| 精品久久久久久无码免费| 日本牲交大片无遮挡| 国产国产裸模裸模私拍视频| 99国产精品久久久久久久成人热 | 色无码av在线播放| 荫道bbwbbb高潮潮喷| 亚洲va欧美va天堂v国产综合 | 中文字幕aⅴ人妻一区二区| 天天爽夜夜爽人人爽从早干到睌| 大帝a∨无码视频在线播放| 少妇av射精精品蜜桃专区| 韩国精品福利一区二区三区 |