在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PHACTR1 Antibody, HRP conjugated

  • 中文名稱:
    PHACTR1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA017880LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PHACTR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PHACTR1
  • 別名:
    PHACTR1 antibody; KIAA1733 antibody; RPEL1 antibody; Phosphatase and actin regulator 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphatase and actin regulator 1 protein (263-387AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization.
  • 基因功能參考文獻:
    1. our study suggests that several PHACTR1 and SLC22A3 gene polymorphisms may exert a protective effect against the CAD in the Chinese Han male population. PMID: 27893421
    2. PHACTR1 is a key atherosclerosis candidate gene since it is regulated by atherogenic stimuli in macrophages and endothelial cells PMID: 27187934
    3. Stimulation of Slack K(+) channels alters mass at the plasma membrane by triggering dissociation of Phactr-1. PMID: 27545877
    4. CRISPR-edited stem cell-derived endothelial cells demonstrate rs9349379, a common SNP in the 3 intron of the PHACTR1 gene, regulates expression of endothelin 1 (EDN1), a gene located 600 kb upstream of PHACTR1. The known physiologic effects of EDN1 on the vasculature may explain the pattern of risk for the five associated vascular diseases. PMID: 28753427
    5. To evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. Results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population. PMID: 27517945
    6. the expression of PHACTR1 by genotypes in primary human fibroblasts showed higher expression in rs9349379-A carriers . Phactr1 knockdown in zebrafish resulted in dilated vessels indicating subtle impaired vascular development PMID: 27792790
    7. There was no significant association between the presence of risk alleles of rs12526453 and coronary heart disease in an Iranian population. PMID: 28287809
    8. our result highlighted the pivotal role of phactr-1 protein in the pathogenesis of atherosclerosis. PMID: 26362351
    9. The rs12526453 CC homozygotes (previously associated with increased risk of myocardial infarction) showed, in 2 independent samples, better long-term survival. PMID: 26086777
    10. GWAS analysis of 1,393 cervical artery dissection cases and 14,416 controls showed that the rs9349379[G] allele was associated with lower risk. This was confirmed independent follow-up samples. PMID: 25420145
    11. a novel signaling route whereby TGF-beta silences the expression of miR-584, resulting in enhanced PHACTR1 expression, and further leading to actin rearrangement and breast cancer cell migration. PMID: 23479725
    12. 3 loci from related cardiovascular genomewide studies were significant: PHACTR1 in large-vessel disease (P=2.63e(-6)), PITX2 in cardioembolic stroke (P=4.78e(-8)), and ZFHX3 in cardioembolic stroke (P=5.50e(-7)). PMID: 23042660
    13. Results from this GWAS support a central role of PHACTR1 in CAD susceptibility irrespective of lifestyle and ethnic divergences. PMID: 22745674
    14. Phactr-1 is a key component in the angiogenic process PMID: 21939755
    15. Findings suggest that PHACTR-1 is likely to be a key regulator of endothelial cell function properties. PMID: 21798305
    16. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20738937
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 20971364
    18. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    19. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19198609

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell junction, synapse. Nucleus.
  • 蛋白家族:
    Phosphatase and actin regulator family
  • 組織特異性:
    Detected in umbilical vein endothelial cells.
  • 數據庫鏈接:

    HGNC: 20990

    OMIM: 608723

    KEGG: hsa:221692

    STRING: 9606.ENSP00000329880

    UniGene: Hs.436996



主站蜘蛛池模板: 2019日韩中文字幕mv | 亚洲乱码国产乱码精品精大量| 中文字幕一区二区人妻电影| 久久久亚洲欧洲日产av| 国产欧美日韩另类在线专区| 亚洲国产成人高清影视| 亚洲精品乱码久久久久久按摩| 亚洲愉拍自拍欧美精品| 日本强好片久久久久久aaa| 久久香蕉国产线看观看怡红院妓院| 中国精品无码免费专区午夜| av无码av在线a∨天堂毛片| 国产精品99久久久久久董美香| 老熟女乱子伦| 欧美精品中文字幕亚洲专区 | 欧美极品色午夜在线视频 | av无码av无码专区| √最新版天堂资源网在线下载| 一本大道伊人av久久乱码| 俺也来俺也去俺也射| 亚洲精品亚洲人成在线观看| 日本亲子乱子伦xxxx50路| 蜜桃av麻豆av果冻传媒| 人妻去按摩店被黑人按中出| 天天燥日日燥| 久久国产乱子伦精品免费女人| 欧美日韩国产中文高清视频| 亚洲人成色77777| 白又丰满大屁股bbbbb| 国内精品九九久久久精品| 亚洲国产成人久久一区久久| 国产精品久久久久久人妻精品| 亚洲国产成人一区二区精品区| 97人妻无码一区| 精品综合久久久久久97| 麻豆国产一区二区三区四区| 久久精品国产大片免费观看| 海角社区在线视频播放观看| 免费做a爰片久久毛片a片下载| 国产无遮挡18禁无码网站免费| 97香蕉碰碰人妻国产欧美|