在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDLIM5 Antibody, HRP conjugated

  • 中文名稱:
    PDLIM5兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA822223LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDLIM5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDLIM5
  • 別名:
    ENH antibody; ENH1 antibody; Enigma homolog antibody; Enigma like LIM domain protein antibody; Enigma like PDZ and LIM domains protein antibody; Enigma-like PDZ and LIM domains protein antibody; L 9 antibody; L9 antibody; LIM antibody; PDLI5_HUMAN antibody; PDLIM5 antibody; PDZ and LIM domain 5 antibody; PDZ and LIM domain protein 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PDZ and LIM domain protein 5 protein (268-404AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
  • 基因功能參考文獻:
    1. this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidneyAE1 and actin cytoskeleton-associated proteins in polarized cells PMID: 28045035
    2. PDLIM5 promotes papillary thyroid carcinoma via activation of the Ras-ERK pathway. PMID: 29574154
    3. PDLIM5 was strongly up-regulated during cardiomyogenesis and novel stage-specific isoforms were detected for PDLIM5 PMID: 28139119
    4. Findings provide evidence of shared genetic variants in PDLIM5 gene influencing alcohol dependence, type 2 diabetes, and hypertension. PMID: 27693979
    5. The study provides evidence of several genetic variants within the PDLIM5 gene and interactions between PDLIM5 and steroid use influencing cancer. PMID: 27350677
    6. It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia. PMID: 24064681
    7. PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
    8. The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD. PMID: 23031404
    9. LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner. PMID: 21266195
    10. Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder. PMID: 14743183
    11. It is confirmed a decreased expression of LIM in the lymphoblastoid cell lines from patients with bipolar I disorder and schizophrenia. PMID: 15362566
    12. Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse. PMID: 15555569
    13. Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder. PMID: 16044170
    14. ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors PMID: 16549780
    15. Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant. PMID: 16595163
    16. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients. PMID: 17287082
    17. our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia PMID: 18021463
    18. PDLIM5 gene is associated with recurrent major depressive disorder. PMID: 18197271
    19. tested for an association between three single nucleotide polymorphisms at the PDLIM5 gene and lithium prophylaxis in a Sardinian sample comprised of 155 bipolar patients treated with lithium PMID: 18456508
    20. PDLIM5 may have a minor effect on susceptibility to bipolar disorder in Caucasians. PMID: 18496208
    21. The aim of this study was to investigate the association between PDLIM5 single nucleotide polymorphisms and bipolar disorder in a case-control sample. PMID: 18496210
    22. Our results suggest that PDLIM5 might play a role in susceptibility to bipolar disorder among the Chinese Han population. PMID: 19448850

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, synapse, postsynaptic density. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cytoplasm, cytosol.
  • 組織特異性:
    Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
  • 數據庫鏈接:

    HGNC: 17468

    OMIM: 605904

    KEGG: hsa:10611

    STRING: 9606.ENSP00000321746

    UniGene: Hs.480311



主站蜘蛛池模板: 精品高潮呻吟99av无码视频| 久久精品国产免费播| 国产剧情无码播放在线看| 人体内射精一区二区三区| 日韩精品一区二区午夜成人版| 日本大乳高潮视频在线观看| 色窝窝色蝌蚪在线视频| 中文字幕乱码一区二区三区免费| 国产免费又色又爽又黄软件| 国产精品高潮呻吟av久久黄| 国产伦久视频免费观看视频| 尹人香蕉久久99天天拍久女久| 国产亚洲日韩在线播放更多| 日本亚洲欧美高清专区vr专区 | 国产在线精品一区二区三区| 亚洲伊人久久综合影院| 久久er99热精品一区二区| 黑人粗大猛烈进出高潮视频| 亚洲精品无码中文久久字幕| 亚洲精品黑牛一区二区三区| 国产熟女一区二区三区五月婷| 国产精品无码无卡无需播放器| 亚洲午夜理论片在线观看| 国产片免费福利片永久| 中文毛片无遮挡高潮免费| 亚洲精品美女久久7777777| 久久97国产超碰青草| 鲁一鲁av2019在线| 色五月丁香六月欧美综合| 国产乱人伦av在线无码| 在线天堂www在线国语对白| 无码少妇一区二区三区浪潮av| 天天综合色天天综合色hd| 欧洲乱码伦视频免费| 亚洲精品国产第一区第二| 18禁无遮挡羞羞污污污污网站| 午夜天堂一区人妻| 又大又长粗又爽又黄少妇视频| 老司机无码精品a| 国产精品无码一区二区牛牛| 国产大片黄在线观看|