在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDLIM5 Antibody, Biotin conjugated

  • 中文名稱:
    PDLIM5兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA822223LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDLIM5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDLIM5
  • 別名:
    ENH antibody; ENH1 antibody; Enigma homolog antibody; Enigma like LIM domain protein antibody; Enigma like PDZ and LIM domains protein antibody; Enigma-like PDZ and LIM domains protein antibody; L 9 antibody; L9 antibody; LIM antibody; PDLI5_HUMAN antibody; PDLIM5 antibody; PDZ and LIM domain 5 antibody; PDZ and LIM domain protein 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PDZ and LIM domain protein 5 protein (268-404AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
  • 基因功能參考文獻:
    1. this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidneyAE1 and actin cytoskeleton-associated proteins in polarized cells PMID: 28045035
    2. PDLIM5 promotes papillary thyroid carcinoma via activation of the Ras-ERK pathway. PMID: 29574154
    3. PDLIM5 was strongly up-regulated during cardiomyogenesis and novel stage-specific isoforms were detected for PDLIM5 PMID: 28139119
    4. Findings provide evidence of shared genetic variants in PDLIM5 gene influencing alcohol dependence, type 2 diabetes, and hypertension. PMID: 27693979
    5. The study provides evidence of several genetic variants within the PDLIM5 gene and interactions between PDLIM5 and steroid use influencing cancer. PMID: 27350677
    6. It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia. PMID: 24064681
    7. PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
    8. The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD. PMID: 23031404
    9. LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner. PMID: 21266195
    10. Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder. PMID: 14743183
    11. It is confirmed a decreased expression of LIM in the lymphoblastoid cell lines from patients with bipolar I disorder and schizophrenia. PMID: 15362566
    12. Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse. PMID: 15555569
    13. Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder. PMID: 16044170
    14. ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors PMID: 16549780
    15. Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant. PMID: 16595163
    16. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients. PMID: 17287082
    17. our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia PMID: 18021463
    18. PDLIM5 gene is associated with recurrent major depressive disorder. PMID: 18197271
    19. tested for an association between three single nucleotide polymorphisms at the PDLIM5 gene and lithium prophylaxis in a Sardinian sample comprised of 155 bipolar patients treated with lithium PMID: 18456508
    20. PDLIM5 may have a minor effect on susceptibility to bipolar disorder in Caucasians. PMID: 18496208
    21. The aim of this study was to investigate the association between PDLIM5 single nucleotide polymorphisms and bipolar disorder in a case-control sample. PMID: 18496210
    22. Our results suggest that PDLIM5 might play a role in susceptibility to bipolar disorder among the Chinese Han population. PMID: 19448850

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, synapse, postsynaptic density. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cytoplasm, cytosol.
  • 組織特異性:
    Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
  • 數據庫鏈接:

    HGNC: 17468

    OMIM: 605904

    KEGG: hsa:10611

    STRING: 9606.ENSP00000321746

    UniGene: Hs.480311



主站蜘蛛池模板: 久久精品2021国产| 国产精品亚亚洲欧关中字幕| 国产 国语对白 露脸| 国产成人无码www免费视频播放 | 亚洲毛片无码不卡av在线播放| 99久久久无码国产精品试看| 久久综合九色综合97网| 久久青青草原国产精品最新片| 嫩草国产福利视频一区二区| 网禁拗女稀缺资源在线观看| 欧美性猛交99久久久久99按摩| 日韩成人无码| 97人妻无码专区| av第一福利网站| 国精产品999国精产品官网| 亚洲欧美中文字幕5发布| 国产美女嘘嘘嘘嘘嘘| 国产精品天干在线观看| 免费网站观看www在线观看| 亚洲男人av香蕉爽爽爽爽| 日日碰狠狠躁久久躁2023| 精品国产一区二区三区av孞弋| 日韩不卡1卡2卡三卡2021免费 | 国产成人精品999视频| 永久免费无码网站在线观看| 美女露全乳无遮掩视频| 98色婷婷在线| 天下第一社区视频www日本| 最新国产在线拍揄自揄视频| 蜜桃精品成人影片| 成在人线av无码免费高潮水老板 | 欧美又大粗又爽又黄大片视频| 欧美激欧美啪啪片免费看| 精品一区二区三区影院在线午夜| 无码乱肉视频免费大全合集| 亚洲夜夜性无码| 日本三级理论久久人妻电影| 午夜人妻理论片天堂影院| 国产精品久久久久久久久久红粉| 亚洲日本中文字幕天天更新| 免费无码黄动漫十八禁|