在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDLIM5 Antibody, Biotin conjugated

  • 中文名稱:
    PDLIM5兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA822223LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDLIM5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDLIM5
  • 別名:
    ENH antibody; ENH1 antibody; Enigma homolog antibody; Enigma like LIM domain protein antibody; Enigma like PDZ and LIM domains protein antibody; Enigma-like PDZ and LIM domains protein antibody; L 9 antibody; L9 antibody; LIM antibody; PDLI5_HUMAN antibody; PDLIM5 antibody; PDZ and LIM domain 5 antibody; PDZ and LIM domain protein 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PDZ and LIM domain protein 5 protein (268-404AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
  • 基因功能參考文獻:
    1. this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidneyAE1 and actin cytoskeleton-associated proteins in polarized cells PMID: 28045035
    2. PDLIM5 promotes papillary thyroid carcinoma via activation of the Ras-ERK pathway. PMID: 29574154
    3. PDLIM5 was strongly up-regulated during cardiomyogenesis and novel stage-specific isoforms were detected for PDLIM5 PMID: 28139119
    4. Findings provide evidence of shared genetic variants in PDLIM5 gene influencing alcohol dependence, type 2 diabetes, and hypertension. PMID: 27693979
    5. The study provides evidence of several genetic variants within the PDLIM5 gene and interactions between PDLIM5 and steroid use influencing cancer. PMID: 27350677
    6. It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia. PMID: 24064681
    7. PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
    8. The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD. PMID: 23031404
    9. LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner. PMID: 21266195
    10. Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder. PMID: 14743183
    11. It is confirmed a decreased expression of LIM in the lymphoblastoid cell lines from patients with bipolar I disorder and schizophrenia. PMID: 15362566
    12. Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse. PMID: 15555569
    13. Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder. PMID: 16044170
    14. ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors PMID: 16549780
    15. Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant. PMID: 16595163
    16. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients. PMID: 17287082
    17. our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia PMID: 18021463
    18. PDLIM5 gene is associated with recurrent major depressive disorder. PMID: 18197271
    19. tested for an association between three single nucleotide polymorphisms at the PDLIM5 gene and lithium prophylaxis in a Sardinian sample comprised of 155 bipolar patients treated with lithium PMID: 18456508
    20. PDLIM5 may have a minor effect on susceptibility to bipolar disorder in Caucasians. PMID: 18496208
    21. The aim of this study was to investigate the association between PDLIM5 single nucleotide polymorphisms and bipolar disorder in a case-control sample. PMID: 18496210
    22. Our results suggest that PDLIM5 might play a role in susceptibility to bipolar disorder among the Chinese Han population. PMID: 19448850

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, synapse, postsynaptic density. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cytoplasm, cytosol.
  • 組織特異性:
    Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
  • 數據庫鏈接:

    HGNC: 17468

    OMIM: 605904

    KEGG: hsa:10611

    STRING: 9606.ENSP00000321746

    UniGene: Hs.480311



主站蜘蛛池模板: 日本新janpanese乱熟| 亚洲一区二区观看播放| 久久国产精品成人影院| 欧美成人精品福利视频| 中文字幕第一区高清av| 天堂а√中文最新版在线| 粗大的内捧猛烈进出少妇视频| 国产片av片永久免费观看| 偷妻之寂寞难耐2中文字幕| 精品人妻系列无码一区二区三区| 国产精品欧美一区二区三区不卡| 女人裸体性做爰视频| 失禁潮痉挛潮喷av在线无码| 国产无遮挡乱子伦免费精品| 国产日韩欧美不卡在线二区| 欧美人与性动交α欧美精品| 国产精品特级毛片一区二区三区| 亚洲国产成人综合一区二区三区| 久久午夜色播影院| 亚洲人成线无码7777| 亚洲欧洲中文日韩久久av乱码 | 国产成人三级在线视频网站观看| 久久国产福利国产秒拍| 性人久久网av| 亚洲精品一品区二品区三区 | 香蕉在线 亚洲 欧美 专区| 色www视频永久免费| 国产亚洲成av人片在线观看 | 无码办公室丝袜ol中文字幕| 青青草国产成人99久久| 亚洲va久久久噜噜噜久久天堂| 国产无限次数成版人视频在线| 日韩人妻少妇一区二区三区| 国产精品亚洲色婷婷99久久精品| 57pao成人国产永久免费视频| 欧美日韩不卡视频合集| 少妇精品偷拍高潮少妇小说| 一区二区传媒有限公司| 亚洲日韩乱码一区二区三区四区| 少妇午夜啪爽嗷嗷叫视频| 国产亚洲va在线电影|