在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDLIM4 Antibody

  • 中文名稱:
    PDLIM4兔多克隆抗體
  • 貨號:
    CSB-PA017735LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: PDLIM4 antibody at 6.1µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 36, 26 kDa
      Observed band size: 36 kDa
    • Immunoprecipitating PDLIM4 in K562 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA017735LA01HU in K562 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA017735LA01HU (6µg) + K562 whole cell lysate (500µg)
      Lane 3: K562 whole cell lysate (20µg)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDLIM4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDLIM4
  • 別名:
    Enigma homolog antibody; LIM domain protein antibody; LIM domain protein RIL antibody; LIM protein RIL antibody; PDLI4_HUMAN antibody; PDLIM 4 antibody; PDLIM4 antibody; PDZ and LIM domain 4 antibody; PDZ and LIM domain protein 4 antibody; Reversion induced LIM protein antibody; Reversion-induced LIM protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PDZ and LIM domain protein 4 protein (81-243AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PDLIM4 Antibody (CSB-PA017735LA01HU),的標記方式是Non-conjugated。對于PDLIM4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017735LB01HU PDLIM4 Antibody, HRP conjugated ELISA
    FITC CSB-PA017735LC01HU PDLIM4 Antibody, FITC conjugated
    Biotin CSB-PA017735LD01HU PDLIM4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IP
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IP 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons.; Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration.
  • 基因功能參考文獻:
    1. Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival. PMID: 22695491
    2. Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein. PMID: 21636573
    3. RIL and its variant sequences may be an important determinant of osteoporosis PMID: 12908099
    4. Ril modulates actin stress fiber turnover and enhances the association with actinin and actins. PMID: 14729062
    5. Results showed that the hypermethylation of PDLIM4 gene could be used as a sensitive molecular tool in detection of prostate. PMID: 16489065
    6. RIL methylation is a marker of adverse prognosis independent of chromosome 5 and 7 deletions. PMID: 17332327
    7. several genes that are known to be regulated by DNA methylation were up-regulated dramatically by integrin alpha6beta4 expression, including S100A4, FST, PDLIM4, CAPG, and Nkx2.2. PMID: 19011242
    8. PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells. PMID: 19212833
    9. Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. PMID: 19307596

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome.; [Isoform 2]: Cytoplasm.
  • 組織特異性:
    [Isoform 2]: Found in brain.
  • 數據庫鏈接:

    HGNC: 16501

    OMIM: 603422

    KEGG: hsa:8572

    STRING: 9606.ENSP00000253754

    UniGene: Hs.424312



主站蜘蛛池模板: 国产白嫩护士被弄高潮| 亚洲中文字幕无码卡通动漫野外| 亚洲色无码专区在线观看| 欧美极品少妇无套实战| 97人妻人人做人碰人人爽| 欧美性色黄大片www喷水| 米奇影院888奇米色99在线| 男人用嘴添女人下身免费视频 | 国产精品18久久久久久麻辣| 国产亚洲日韩在线三区| 天天躁夜夜躁狠狠躁2021| 亚洲国产精品久久久久4婷婷| 亚洲国产精品福利片在线观看| 午夜熟女插插xx免费视频| 无码av片av片av无码| 天天槽夜夜槽槽不停| 初尝黑人巨砲波多野结衣| 美女又黄又免费的视频| 免费人成网站在线观看不卡| 国产亚洲日韩欧美另类丝瓜app| 影音先锋每日av色资源站| 中文字幕丰满乱孑伦无码专区| 一本一道av中文字幕无码| 18禁黄久久久aaa片| 无码人妻丰满熟妇区96| 日本大乳高潮视频在线观看| 国产无套护士在线观看| 国产午夜无码福利在线看网站| 欧美乱妇高清无乱码| 东方aⅴ免费观看久久av| 中国少妇内射xxxhd| 日本va在线视频播放| 国产9 9在线 | 中文| 色老99久久九九爱精品| 免费国产午夜视频在线| 欧美性猛交99久久久久99按摩| 国产美足白丝榨精在线观看sm| 精品无人乱码高清在线观看| 无码无套少妇毛多69xxx| 国产成人午夜福利在线观看| 免费三级现频在线观看播放|