在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDLIM4 Antibody

  • 中文名稱:
    PDLIM4兔多克隆抗體
  • 貨號:
    CSB-PA287378
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA287378(PDLIM4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA287378(PDLIM4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA287378(PDLIM4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PDLIM4
  • 別名:
    Enigma homolog antibody; LIM domain protein antibody; LIM domain protein RIL antibody; LIM protein RIL antibody; PDLI4_HUMAN antibody; PDLIM 4 antibody; PDLIM4 antibody; PDZ and LIM domain 4 antibody; PDZ and LIM domain protein 4 antibody; Reversion induced LIM protein antibody; Reversion-induced LIM protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human PDLIM4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons.; Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration.
  • 基因功能參考文獻(xiàn):
    1. Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival. PMID: 22695491
    2. Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein. PMID: 21636573
    3. RIL and its variant sequences may be an important determinant of osteoporosis PMID: 12908099
    4. Ril modulates actin stress fiber turnover and enhances the association with actinin and actins. PMID: 14729062
    5. Results showed that the hypermethylation of PDLIM4 gene could be used as a sensitive molecular tool in detection of prostate. PMID: 16489065
    6. RIL methylation is a marker of adverse prognosis independent of chromosome 5 and 7 deletions. PMID: 17332327
    7. several genes that are known to be regulated by DNA methylation were up-regulated dramatically by integrin alpha6beta4 expression, including S100A4, FST, PDLIM4, CAPG, and Nkx2.2. PMID: 19011242
    8. PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells. PMID: 19212833
    9. Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. PMID: 19307596

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 1]: Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome.; [Isoform 2]: Cytoplasm.
  • 組織特異性:
    [Isoform 2]: Found in brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16501

    OMIM: 603422

    KEGG: hsa:8572

    STRING: 9606.ENSP00000253754

    UniGene: Hs.424312



主站蜘蛛池模板: 久久国产精品久久久久久| 亚洲国产欧美在线看片一国产| 最新国产精品久久精品| 沈阳熟女露脸对白视频| 男女啪啪免费体验区| 十八岁以下禁止观看黄下载链接| 国产精品亚洲精品日韩已满| 亚洲人禽杂交av片久久| 一本一久本久a久久精品综合| 国产女人被狂躁到高潮小说| 国产精品一区二区av| 国语对白做受xxxxx在| 97久久草草超级碰碰碰| 国产精品成人va在线观看| 亚洲人av在线无码影院观看| av综合网男人的天堂| 久久久久久久久888| 狠狠躁夜夜躁人人爽天天不卡 | av人摸人人人澡人人超碰小说| 日本免码va在线看免费| 在线天堂中文官网| 亚洲成av人片不卡无码| 中文字幕第一区高清av| 亚洲日韩a∨无码久| 麻豆国产一区二区三区四区| 国产精品无码无需播放器| 国内精品久久久久影院蜜芽| 韩国无码av片在线观看网站| 国产人妖xxxx做受视频| 亚洲一本大道av久在线播放| 国产内射xxxxx在线| 成人性生交大免费看| 国产精品 无码专区| 精品久久久久久777米琪桃花| 在线 | 国产精品星空传媒丿| 精品国产美女福到在线不卡 | 欧美内射rape视频| 人妻精品制服丝袜久久久| 国内自拍久久久久影院| 无码av免费一区二区三区| 日本孕妇潮喷高潮视频|