在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PDLIM1 Antibody

PDLIM1 Antibody

  • 中文名稱：
    PDLIM1兔多克隆抗體
  • 貨號：
    CSB-PA001724
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using CLP36 Polyclonal Antibody
    • Western Blot analysis of K562 cells using CLP36 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PDLIM1
  • 別名：
    C terminal LIM domain protein 1 antibody; C-terminal LIM domain protein 1 antibody; Carboxy terminal LIM domain protein 1 antibody; CLIM 1 antibody; CLIM1 antibody; CLP 36 antibody; CLP36 antibody; Elfin antibody; Enigma antibody; Enigma homolog antibody; hCLIM 1 antibody; hCLIM1 antibody; LIM domain protein CLP 36 antibody; LIM domain protein CLP-36 antibody; LIM domain protein CLP36 antibody; PDLI1_HUMAN antibody; PDLIM 1 antibody; Pdlim1 antibody; PDZ and LIM domain 1 antibody; PDZ and LIM domain protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CLP36.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts.
  • 基因功能參考文獻：
    1. PDLIM1 was shown to interact with p75(NTR) in highly invasive patient-derived glioma stem cells/tumor-initiating cells and shRNA knockdown of PDLIM1 in vitro and in vivo results in complete ablation of p75(NTR)-mediated invasion. PMID: 26119933
    2. downregulation of PDLIM1 in colorectal cancer samples correlated with reduced E-cadherin and membrane beta-catenin levels PMID: 26701804
    3. Our results identify CLP36 as an important regulator of breast cancer cell migration and metastasis, and shed light on how increased CLP36 expression contributes to the progression of breast cancer. PMID: 24662836
    4. Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability. PMID: 22922308
    5. Robust co-regulation of tyrosine phosphorylation sites has been revealed on novel protein interactions between EGFR and PDLIM1. PMID: 22851037
    6. PDLIM1 showed moderate parent-of origin effects for some single nucleotide polymorphisms in attention deficit disorder with hyperactivity. PMID: 21651830
    7. Alpha-actinin-4 and CLP36 protein deficiencies contribute to podocyte defects in multiple human glomerulopathies PMID: 21680739
    8. results establish the CLP-36 PDZ-LIM protein as an adapter, recruiting the Clik1 kinase to actin stress fibers in nonmuscle cells, and suggest that Clik1 represents a novel regulator of actin stress fibers PMID: 11973348
    9. We present evidence for the exclusive protein expression of CLP36 in proliferative and early post-proliferative trophoblast cells. PMID: 16609848
    10. Enigma protein shown to interact with alpha actinin 2 by yeast two-hybrid screening and immunochemistry (co-localization at myocardial Z-disks). PMID: 10861853
    11. CLP-36 contains a PDZ- and LIM domain, is widely expressed, interacts with actinin-1, actinin-2 and actinin-4, and localizes to actin stress fibers. The gene (7 exons) is localised to contig NT_008878.2 on chromosome 10. PMID: 11110697

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
  • 組織特異性：
    Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ov
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2067

    OMIM: 605900

    KEGG: hsa:9124

    STRING: 9606.ENSP00000360305

    UniGene: Hs.368525



主站蜘蛛池模板： 国产极品美女高潮抽搐免费网站| 天天狠天天透天干天干| 亚洲精品一区二区三区新线路| 亚洲大乳高潮日本专区| 四十如虎的丰满熟妇啪啪| 无码精品人妻一区二区三区98| 久热这里只有精品12| 成人性生交大免费看| 中文字幕丰满乱子伦无码专区| 欧美人与动牲交zooz乌克兰| 亚洲欧美色αv在线影视| 国产亚洲tv在线观看| 成人无码视频免费播放| 夜夜春夜夜爽| 国产午夜成人免费看片| 亚洲乱码无码永久不卡在线 | 成人av无码一区二区三区| 国产又大又粗又爽的毛片| 亚洲欧美日本久久综合网站| 欧美另类又黄又爽的a片| 羞国产在线拍揄自揄视频| 中文字幕 人妻熟女| 久久久国产一区二区三区四区小说 | 新区乱码无人区二精东| 亚洲精品tv久久久久久久久j| 亚洲熟妇无码av不卡在线| 国产精品午夜无码av体验区| 狠狠色综合网站久久久久久久高清| 秋霞午夜久久午夜精品| 国产成人亚洲精品无码最新| 色婷婷亚洲一区二区综合| 亚洲欧美乱日韩乱国产| 长腿校花无力呻吟娇喘| 国产亚洲香蕉线播放αv38| 无码av高潮喷水无码专区线| 成熟妇人a片免费看网站| 亚洲乱码中文字幕在线| 国产亚洲精品久久久久动漫| 青青草国产免费国产是公开| 欧美精品一区二区黄a片| 18禁无遮挡免费视频网站|