在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PDGFC Antibody

PDGFC Antibody

  • 中文名稱：
    PDGFC兔多克隆抗體
  • 貨號：
    CSB-PA146607
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA146607(PDGFC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA146607(PDGFC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Fallotein antibody; hSCDGF antibody; PDGF-C antibody; PDGFC antibody; PDGFC latent form antibody; PDGFC receptor-binding form antibody; PDGFC_HUMAN antibody; Platelet derived growth factor C antibody; Platelet-derived growth factor C; receptor-binding form antibody; SCDGF antibody; Secretory growth factor like protein antibody; Secretory growth factor like protein fallotein antibody; Spinal cord derived growth factor antibody; Spinal cord-derived growth factor antibody; VEGF E antibody; VEGF-E antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human PDGFC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
  • 基因功能參考文獻：
    1. There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB, PDGFC and PDGFD) that reside on chromosomes 7, 22, 4 and 11. PMID: 28267575
    2. We conclude that PDGF-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset PMID: 26687981
    3. High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. PMID: 27033449
    4. PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR). PMID: 25383675
    5. Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells. PMID: 24612214
    6. The results indicate that PDGF-C upregulation and calpain-3 downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins PMID: 24126726
    7. Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation. PMID: 24421315
    8. Data indicate uPA (plau) and PAI1 (Serpine1) were up-regulated in human PDGF-C Tg mice, suggesting that uPA could be compensating for the loss of tissue-type plasminogen activator (tPA) activity in PDGF-C Tg; tpa KO mice. PMID: 24269585
    9. High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma. PMID: 23929039
    10. PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review] PMID: 23714575
    11. Results indicate that the alpha-SMA inducing effect of M2 macrophages is in part mediated by secretion of PGDF-CC. PMID: 23182716
    12. Single nucleotide polymorphisms in the PDGF-C gene are linked to the development of oral clefts. PMID: 23029525
    13. Platelet-derived growth factor-C (PDGF-C) activation by serine proteases. PMID: 22035541
    14. Melanoma cell-derived platelet-derived growth factor (PDGF)-AA and PDGF-CC were identified as major mediators that signal through PDGFR-alpha and thus induce HAS2-mediated HA synthesis in fibroblasts PMID: 21993555
    15. Data suggest that the variant rs1425486 genotype could differentially affect targeting by miR-425 in ovarian cancer cells leading to higher PDGFC expression. PMID: 21118967
    16. PDGFC mRNA expression were down-regulated in biopsies containing infiltrated lymphocytes or thyroiditis. PMID: 19968886
    17. Upregulation of PDGFC expression may contribute to the clonal expansion of fibroid-derived smooth muscle cells in the development of uterine fibroids. PMID: 19553600
    18. Data suggest that five novel genes, LUM, PDE3B, PDGF-C, NRG1 and PKD2, have great potential for predicting the efficacy of cisplatin-based chemotherapy against OSCC. PMID: 19569180
    19. Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. PMID: 12032822
    20. determination of PDGFC expression levels in medulloblastoma tumor cell lines PMID: 12176024
    21. PDGF-C has a higher structural homology to the vascular endothelial growth factor than to PDGF-B PMID: 12598536
    22. PDGF-C is constitutively expressed in the human kidney and is upregulated in podocytes and interstitial cells after injury/activation of these cells. PMID: 12707385
    23. In adult human tissues, PDGF-C was largely in smooth muscle. It binds & activate alpha PDGFR, & activates beta PDGFR when it is co-expressed with alpha PDGFR through heterodimer formation. PDGF C is likely to play a role in platelet biology. PMID: 15061151
    24. Plays a role in tissue remodeling. PMID: 15389578
    25. PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis PMID: 15728360
    26. determine the molecular mechanism of tPA-mediated activation of PDGF-C dimer PMID: 15911618
    27. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium. PMID: 17482170
    28. PDGF-C and PDGF-D, like PDGF-A and PDGF-B, play important roles in atherosclerosis by stimulating MMP activity and influencing monocyte migration PMID: 18573494
    29. A novel splice variant of human PDGF-C (PDGF-Cb), which encodes an N-terminally truncated protein, lacking the signal peptide and CUB domain, is reported. PMID: 18588873
    30. The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with cleft lip with or without cleft palate (CL/P) PMID: 19092777
    31. some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF-C PMID: 19111878
    32. PDGFC was identified as target of EWS/ETS transcriptionalderegulation specific to EWS/FLI-1 chimeras in the Ewing Family Tumors suggesting that it may be a significant mediator of EWS/FLI driven oncogenesis. PMID: 11313995

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Secreted. Nucleus. Cytoplasmic granule. Cell membrane.
  • 蛋白家族：
    PDGF/VEGF growth factor family
  • 組織特異性：
    Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutive
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8801

    OMIM: 608452

    KEGG: hsa:56034

    STRING: 9606.ENSP00000422464

    UniGene: Hs.570855



主站蜘蛛池模板： 亚洲无人区码一码二码三码的含义| 久久久久久久综合狠狠综合| 强奷乱码中文字幕熟女一| 精品少妇人妻av免费久久久 | 国产专区一线二线三线码| 丰满的少妇hd高清中文字幕 | 无码免费中文字幕视频| 亚洲成a人片在线观看无码| 亚洲熟妇av日韩熟妇在线| 污18禁污色黄网站免费| 18禁止午夜福利体验区| 欧美性色黄大片| 欧美午夜精品一区二区三区电影| 久久精品无码一区二区app| 西西人体大胆啪啪实拍| 国产婷婷综合在线视频| 国产午夜激无码av毛片不卡| 日本欧美久久久久免费播放网| 亚洲 自拍 色综合图区av| av国産精品毛片一区二区视频| 欧洲美女粗暴牲交免费观看| 欧美 丝袜 自拍 制服 另类| 国产精品视频一区二区亚瑟| 亚洲男人a在天堂线一区| 午夜福利三级理论电影| 久久综合色鬼综合色| 亚洲国产精品无码7777一线| 欧美3p两根一起进高清视频| 综合 欧美 亚洲日本| 亚洲熟妇无码av另类vr影视| 亚洲精品久久国产精品| 久久久久久久97| 午夜福利视频合集1000| 国产偷窥盗摄一区二区| 国内极度色诱视频网站| 狠狠色噜噜狠狠狠8888米奇| 精品国产一区二区三区四区精华液| 亚洲妇女自偷自偷图片| 少妇性l交大片欧洲热妇乱xxx| 久在线精品视频线观看| 中文字幕+乱码+中文字幕一区|