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  4. Human vascular endothelial cell growth factor E,VEGF-E ELISA Kit

Human vascular endothelial cell growth factor E,VEGF-E ELISA Kit

  • 中文名稱(chēng)：
    人血管內(nèi)皮細(xì)胞生長(zhǎng)因子E(VEGF-E)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E15022h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人血管內(nèi)皮細(xì)胞生長(zhǎng)因子E(VEGF-E)酶聯(lián)免疫試劑盒（CSB-E15022h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、尿液、組織培養(yǎng)上清液、組織勻漿樣本中的PDGFC含量。PDGFC即血小板衍生生長(zhǎng)因子C，是在組織發(fā)育、修復(fù)等過(guò)程中發(fā)揮重要作用的分泌型生長(zhǎng)因子。其研究機(jī)制主要圍繞其與受體結(jié)合后激活細(xì)胞內(nèi)信號(hào)傳導(dǎo)通路，調(diào)控細(xì)胞增殖、遷移等，深入研究有助于為相關(guān)疾病的治療提供新靶點(diǎn)與策略。試劑盒檢測(cè)范圍為6.25 pg/mL-400 pg/mL，支持科研人員在體外實(shí)驗(yàn)中定量分析VEGF - E的表達(dá)動(dòng)態(tài)，可廣泛應(yīng)用于細(xì)胞模型構(gòu)建、疾病機(jī)制探索、藥物干預(yù)效果評(píng)估等基礎(chǔ)研究，其寬泛的線性范圍和多樣本兼容性為血管生物學(xué)、腫瘤學(xué)等領(lǐng)域的體外實(shí)驗(yàn)提供了可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Fallotein ELISA Kit; hSCDGF ELISA Kit; PDGF-C ELISA Kit; PDGFC ELISA Kit; PDGFC latent form ELISA Kit; PDGFC receptor-binding form ELISA Kit; PDGFC_HUMAN ELISA Kit; Platelet derived growth factor C ELISA Kit; Platelet-derived growth factor C; receptor-binding form ELISA Kit; SCDGF ELISA Kit; Secretory growth factor like protein ELISA Kit; Secretory growth factor like protein fallotein ELISA Kit; Spinal cord derived growth factor ELISA Kit; Spinal cord-derived growth factor ELISA Kit; VEGF E ELISA Kit; VEGF-E ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類(lèi)型：
    serum, urine, cell culture supernates, tissue homogenates
  • 檢測(cè)范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human VEGF-E in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %85
    Range %80-90
    1:2Average %96
    Range %90-100
    1:4Average %98
    Range %91-105
    1:8Average %90
    Range %82-98
  • 回收率：
    The recovery of human VEGF-E spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9183-98
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    4002.806 2.712 2.759 2.659
    2002.012 2.066 2.039 1.939
    1001.473 1.384 1.429 1.329
    500.958 0.893 0.926 0.826
    250.494 0.473 0.484 0.384
    12.50.321 0.301 0.311 0.211
    6.250.254 0.249 0.252 0.152
    00.102 0.097 0.100 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
  • 基因功能參考文獻(xiàn)：
    1. There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB, PDGFC and PDGFD) that reside on chromosomes 7, 22, 4 and 11. PMID: 28267575
    2. We conclude that PDGF-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset PMID: 26687981
    3. High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. PMID: 27033449
    4. PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR). PMID: 25383675
    5. Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells. PMID: 24612214
    6. The results indicate that PDGF-C upregulation and calpain-3 downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins PMID: 24126726
    7. Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation. PMID: 24421315
    8. Data indicate uPA (plau) and PAI1 (Serpine1) were up-regulated in human PDGF-C Tg mice, suggesting that uPA could be compensating for the loss of tissue-type plasminogen activator (tPA) activity in PDGF-C Tg; tpa KO mice. PMID: 24269585
    9. High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma. PMID: 23929039
    10. PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review] PMID: 23714575
    11. Results indicate that the alpha-SMA inducing effect of M2 macrophages is in part mediated by secretion of PGDF-CC. PMID: 23182716
    12. Single nucleotide polymorphisms in the PDGF-C gene are linked to the development of oral clefts. PMID: 23029525
    13. Platelet-derived growth factor-C (PDGF-C) activation by serine proteases. PMID: 22035541
    14. Melanoma cell-derived platelet-derived growth factor (PDGF)-AA and PDGF-CC were identified as major mediators that signal through PDGFR-alpha and thus induce HAS2-mediated HA synthesis in fibroblasts PMID: 21993555
    15. Data suggest that the variant rs1425486 genotype could differentially affect targeting by miR-425 in ovarian cancer cells leading to higher PDGFC expression. PMID: 21118967
    16. PDGFC mRNA expression were down-regulated in biopsies containing infiltrated lymphocytes or thyroiditis. PMID: 19968886
    17. Upregulation of PDGFC expression may contribute to the clonal expansion of fibroid-derived smooth muscle cells in the development of uterine fibroids. PMID: 19553600
    18. Data suggest that five novel genes, LUM, PDE3B, PDGF-C, NRG1 and PKD2, have great potential for predicting the efficacy of cisplatin-based chemotherapy against OSCC. PMID: 19569180
    19. Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. PMID: 12032822
    20. determination of PDGFC expression levels in medulloblastoma tumor cell lines PMID: 12176024
    21. PDGF-C has a higher structural homology to the vascular endothelial growth factor than to PDGF-B PMID: 12598536
    22. PDGF-C is constitutively expressed in the human kidney and is upregulated in podocytes and interstitial cells after injury/activation of these cells. PMID: 12707385
    23. In adult human tissues, PDGF-C was largely in smooth muscle. It binds & activate alpha PDGFR, & activates beta PDGFR when it is co-expressed with alpha PDGFR through heterodimer formation. PDGF C is likely to play a role in platelet biology. PMID: 15061151
    24. Plays a role in tissue remodeling. PMID: 15389578
    25. PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis PMID: 15728360
    26. determine the molecular mechanism of tPA-mediated activation of PDGF-C dimer PMID: 15911618
    27. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium. PMID: 17482170
    28. PDGF-C and PDGF-D, like PDGF-A and PDGF-B, play important roles in atherosclerosis by stimulating MMP activity and influencing monocyte migration PMID: 18573494
    29. A novel splice variant of human PDGF-C (PDGF-Cb), which encodes an N-terminally truncated protein, lacking the signal peptide and CUB domain, is reported. PMID: 18588873
    30. The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with cleft lip with or without cleft palate (CL/P) PMID: 19092777
    31. some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF-C PMID: 19111878
    32. PDGFC was identified as target of EWS/ETS transcriptionalderegulation specific to EWS/FLI-1 chimeras in the Ewing Family Tumors suggesting that it may be a significant mediator of EWS/FLI driven oncogenesis. PMID: 11313995

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  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Secreted. Nucleus. Cytoplasmic granule. Cell membrane.
  • 蛋白家族：
    PDGF/VEGF growth factor family
  • 組織特異性：
    Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutive
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8801

    OMIM: 608452

    KEGG: hsa:56034

    STRING: 9606.ENSP00000422464

    UniGene: Hs.570855



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