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  4. PDE6D Antibody, FITC conjugated

PDE6D Antibody, FITC conjugated

  • 中文名稱：
    PDE6D兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA526126LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PDE6D Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PDE6D
  • 別名：
    5''-cyclic phosphodiesterase subunit delta antibody; GMP PDE delta antibody; GMP-PDE delta antibody; p17 protein antibody; PDE 6 antibody; PDE 6D antibody; PDE D antibody; PDE6 antibody; PDE6D antibody; PDE6D_HUMAN antibody; PDED antibody; Phosphodiesterase 6D cGMP specific antibody; Phosphodiesterase 6D cGMP specific rod delta antibody; Protein p17 antibody; Retinal rod photoreceptor cGMP phosphodiesterase delta antibody; Retinal rod rhodopsin sensitive cGMP 3' 5' cyclic phosphodiesterase subunit delta antibody; Retinal rod rhodopsin-sensitive cGMP 3'' antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3\',5\'-cyclic phosphodiesterase subunit delta protein (1-150AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
  • 基因功能參考文獻：
    1. PDE6delta binds selectively to the C-terminus of RPGR and that this interaction is critical for RPGR's localization to cilia. PMID: 28172980
    2. Studies indicate that the binding of UNC119 and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner. PMID: 27911709
    3. Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies. PMID: 24166846
    4. RPGR is acting as a scaffold protein recruiting cargo-loaded PDE6D and Arl3 to release lipidated cargo into cilia. PMID: 23559067
    5. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
    6. Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane. PMID: 22179043

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  • 相關(guān)疾病：
    Joubert syndrome 22 (JBTS22)
  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    PDE6D/unc-119 family
  • 組織特異性：
    Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8788

    OMIM: 602676

    KEGG: hsa:5147

    STRING: 9606.ENSP00000287600

    UniGene: Hs.516808



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