在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PDE2A Antibody

PDE2A Antibody

  • 中文名稱：
    PDE2A兔多克隆抗體
  • 貨號：
    CSB-PA017687LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: PDE2A antibody at 2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 106, 104, 105, 79, 88 kDa
      Observed band size: 88 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA017687LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA017687LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA017687LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PDE2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    5''-cyclic phosphodiesterase antibody; cGMP dependent 3'5' cyclic phosphodiesterase antibody; cGMP stimulated phosphodiesterase 1 antibody; cGMP stimulated phosphodiesterase 4 antibody; cGMP-dependent 3'' antibody; cGMP-stimulated phosphodiesterase 2 antibody; CGS PDE antibody; CGS-PDE antibody; cGSPDE antibody; Cyclic GMP stimulated phosphodiesterase antibody; Cyclic GMP-stimulated phosphodiesterase antibody; Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase antibody; PDE 2A antibody; PDE 2A1 antibody; PDE 2A4 antibody; PDE2A antibody; PDE2A_HUMAN antibody; PDE2A1 antibody; PDE2A4 antibody; phosphodiesterase 2A antibody; Phosphodiesterase 2A cGMP stimulated antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human cGMP-dependent 3\',5\'-cyclic phosphodiesterase protein (15-226AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PDE2A Antibody (CSB-PA017687LA01HU)，的標記方式是Non-conjugated。對于PDE2A Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017687LB01HU PDE2A Antibody, HRP conjugated ELISA
    FITC CSB-PA017687LC01HU PDE2A Antibody, FITC conjugated
    Biotin CSB-PA017687LD01HU PDE2A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line).; Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
  • 基因功能參考文獻：
    1. the well-known interaction between AIP and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity. PMID: 28427099
    2. Lu AF33241 represents a novel PDE2A/PDE10A inhibitor tool which can penetrate the blood brain barrier. PMID: 25941078
    3. Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised beta-adrenergic Signaling in an induced pluripotent stem cell model of dilated cardiomyopathy. PMID: 26095046
    4. curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition PMID: 25230992
    5. PDE2A is involved in growth and invasion of human malignant melanoma PMP cells. PMID: 24705027
    6. This study reports the X-ray crystal structure of PDE2A in complex with a highly selective, nanomolar inhibitor (BAY60-7550) at 1.9 A resolution, and the structure of apo PDE2 at 2.0 A resolution. PMID: 23899287
    7. PDE2 overexpression in healthy cardiomyocytes reduces the rise in cyclic AMP levels and L-type calcium current amplitude, and abolishes the inotropic effect following acute beta-adrenergic receptor stimulation. PMID: 23810893
    8. Our results demonstrated that the PDE2A2 variant carrying point mutations is expressed in PMP cells and may affect cell cycle progression by modulating cyclin A expression. PMID: 23381931
    9. found in smooth muscle wall of blood vessels transversing the clitoral supepithelial and stromal space PMID: 21697861
    10. Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design PMID: 21766240
    11. the phosphodiesterase 2A isoform localized to mitochondria regulates respiration PMID: 21724846
    12. Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A suggesting this PDE may be the more important regulator of cAMP in human platelets. PMID: 12038792
    13. TNF-alpha-mediated up-regulation of PDE2 may destabilize endothelial barrier function in sepsis PMID: 15650061
    14. Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. PMID: 19390057
    15. report the X-ray crystal structures of a PDE protein that includes both catalytic and regulatory domains, namely, PDE2A containing the N-terminal GAF domains and the catalytic domain. PMID: 19828435

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform PDE2A3]: Cell membrane; Lipid-anchor.; [Isoform PDE2A2]: Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane.; [Isoform PDE2A1]: Cytoplasm.; [Isoform 5]: Mitochondrion.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE2 subfamily
  • 組織特異性：
    Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 8777

    OMIM: 602658

    KEGG: hsa:5138

    STRING: 9606.ENSP00000334910

    UniGene: Hs.503163



主站蜘蛛池模板： 亚洲另类欧美在线电影| 又黄又爽又无遮挡免费的网站| 国产精品一区二区在线观看| 亚洲欧美日韩国产综合点击进入| 亚洲桃色天堂网| 一本色综合亚洲精品蜜桃冫| 亚洲欧美日韩成人高清在线一区| 狠狠色噜噜狠狠色综合久| 国产ktv交换配乱婬视频| 国产精品女丝袜白丝袜| 日本夜爽爽一区二区三区| 日本高清视频网站www| 婷婷四虎东京热无码群交双飞视频| 亚洲乱色熟女一区二区三区丝袜| 国产午夜毛片v一区二区三区 | 国产一区二区三区不卡av| 国产影片中文字幕| 久久不见久久见免费视频6无删减| 久久中文精品无码中文字幕下载 | 久久精品人人做人人爱爱漫画| 成人区人妻精品一区二区三区| 午夜理论片yy8860y影院| 男人天堂2018亚洲男人天堂| 成人午夜精品无码一区二区三区| 久久久精品午夜免费不卡| 国产日韩精品欧美2020区| 免费无码午夜福利片69| 少妇伦子伦精品无吗| 欧洲熟妇牲交| 日韩经典精品无码一区| 玩两个丰满老熟女久久网| 老熟女高潮一区二区三区| 亚洲 综合 欧美在线视频| 久久99精品久久久久久蜜芽| 亚洲午夜成人片| 99久久精品精品6精品精品| 宅宅午夜无码一区二区三区| 日本极品少妇videossexhd| 久久亚洲精品中文字幕| 久久毛片免费看一区二区三区 | 性色欲网站人妻丰满中文久久不卡|