在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDE2A Antibody, FITC conjugated

  • 中文名稱:
    PDE2A兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA017687LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDE2A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    5''-cyclic phosphodiesterase antibody; cGMP dependent 3'5' cyclic phosphodiesterase antibody; cGMP stimulated phosphodiesterase 1 antibody; cGMP stimulated phosphodiesterase 4 antibody; cGMP-dependent 3'' antibody; cGMP-stimulated phosphodiesterase 2 antibody; CGS PDE antibody; CGS-PDE antibody; cGSPDE antibody; Cyclic GMP stimulated phosphodiesterase antibody; Cyclic GMP-stimulated phosphodiesterase antibody; Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase antibody; PDE 2A antibody; PDE 2A1 antibody; PDE 2A4 antibody; PDE2A antibody; PDE2A_HUMAN antibody; PDE2A1 antibody; PDE2A4 antibody; phosphodiesterase 2A antibody; Phosphodiesterase 2A cGMP stimulated antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human cGMP-dependent 3',5'-cyclic phosphodiesterase protein (15-226AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line).; Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
  • 基因功能參考文獻:
    1. the well-known interaction between AIP and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity. PMID: 28427099
    2. Lu AF33241 represents a novel PDE2A/PDE10A inhibitor tool which can penetrate the blood brain barrier. PMID: 25941078
    3. Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised beta-adrenergic Signaling in an induced pluripotent stem cell model of dilated cardiomyopathy. PMID: 26095046
    4. curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition PMID: 25230992
    5. PDE2A is involved in growth and invasion of human malignant melanoma PMP cells. PMID: 24705027
    6. This study reports the X-ray crystal structure of PDE2A in complex with a highly selective, nanomolar inhibitor (BAY60-7550) at 1.9 A resolution, and the structure of apo PDE2 at 2.0 A resolution. PMID: 23899287
    7. PDE2 overexpression in healthy cardiomyocytes reduces the rise in cyclic AMP levels and L-type calcium current amplitude, and abolishes the inotropic effect following acute beta-adrenergic receptor stimulation. PMID: 23810893
    8. Our results demonstrated that the PDE2A2 variant carrying point mutations is expressed in PMP cells and may affect cell cycle progression by modulating cyclin A expression. PMID: 23381931
    9. found in smooth muscle wall of blood vessels transversing the clitoral supepithelial and stromal space PMID: 21697861
    10. Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design PMID: 21766240
    11. the phosphodiesterase 2A isoform localized to mitochondria regulates respiration PMID: 21724846
    12. Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A suggesting this PDE may be the more important regulator of cAMP in human platelets. PMID: 12038792
    13. TNF-alpha-mediated up-regulation of PDE2 may destabilize endothelial barrier function in sepsis PMID: 15650061
    14. Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. PMID: 19390057
    15. report the X-ray crystal structures of a PDE protein that includes both catalytic and regulatory domains, namely, PDE2A containing the N-terminal GAF domains and the catalytic domain. PMID: 19828435

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform PDE2A3]: Cell membrane; Lipid-anchor.; [Isoform PDE2A2]: Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane.; [Isoform PDE2A1]: Cytoplasm.; [Isoform 5]: Mitochondrion.
  • 蛋白家族:
    Cyclic nucleotide phosphodiesterase family, PDE2 subfamily
  • 組織特異性:
    Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 8777

    OMIM: 602658

    KEGG: hsa:5138

    STRING: 9606.ENSP00000334910

    UniGene: Hs.503163



主站蜘蛛池模板: 亚洲国产av无码一区二区三区| √天堂资源地址中文在线| 少妇愉情理伦片丰满丰满午夜| 欧美国产激情一区二区在线| av无码国产在线看免费网站| 中文字幕亚洲综合久久菠萝蜜| 欧美孕妇变态重口另类| 无码少妇一区二区浪潮免费| 亚洲国产欧美在线观看片不卡| 国产欧美日韩一区二区三区| 欧美一区内射最近更新| 秋霞av在线露丝片av无码| 精品无码久久久久久尤物| 无套中出极品少妇白浆| 日本特黄特色特爽大片| 国产粉嫩嫩00在线正在播放| 日韩不卡1卡2卡三卡2021免费| 无码熟妇人妻av| 国产午夜鲁丝无码拍拍| 720lu国产刺激无码| 中文毛片无遮挡高潮免费| 青草青草久热精品视频在线观看| 亚洲精品色情aⅴ色戒| 国模大尺度福利视频在线| 日韩av午夜在线观看| 丰满多毛的大隂户毛茸茸| 亚洲成在人线在线播放无码vr| 欧美性猛交xxxx乱大交蜜桃| 久久人人妻人人做人人爽| 国内外精品激情刺激在线| 在线播放偷拍一区精品| 国产成人精品一区二区秒拍| 亚洲精品天天影视综合网| 久久99日韩国产精品久久99| 67194熟妇在线观看线路1| 艳妇臀荡乳欲伦交换在线播放| 久久国产精品免费一区| 欧美色欧美亚洲高清在线视频| 色午夜一av男人的天堂| 国产情侣激情在线视频| aⅴ亚洲 日韩 色 图网站 播放|