在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PASK Antibody

PASK Antibody

  • 中文名稱：
    PASK兔多克隆抗體
  • 貨號：
    CSB-PA822296LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA822296LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PASK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PASK
  • 別名：
    DKFZP434O051 antibody; DKFZp686P2031 antibody; hPASK antibody; KIAA0135 antibody; MGC93882 antibody; mKIAA0135 antibody; PAS domain containing serine/threonine kinase antibody; PAS domain containing serine/threonine protein kinase antibody; PAS domain-containing serine/threonine-protein kinase antibody; PAS kinase antibody; PAS serine/threonine kinase antibody; PAS-kinase antibody; Pask antibody; PASK_HUMAN antibody; PASKIN antibody; STK 37 antibody; STK37 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PAS domain-containing serine/threonine-protein kinase protein (482-602AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PASK Antibody (CSB-PA822296LA01HU)，的標(biāo)記方式是Non-conjugated。對于PASK Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA822296LB01HU PASK Antibody, HRP conjugated ELISA
    FITC CSB-PA822296LC01HU PASK Antibody, FITC conjugated
    Biotin CSB-PA822296LD01HU PASK Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
  • 基因功能參考文獻(xiàn)：
    1. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells. PMID: 23853095
    2. Mutations that affect PAS domain cause a severe protein trafficking defect and change the interactions with Kv11.1 channels. PMID: 23721480
    3. The role of PAS kinase in PASsing the glucose signal. PMID: 22219681
    4. Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion PMID: 22065581
    5. PASK is involved in the regulation of glucagon secretion by glucose and may be a useful target for the treatment of type 2 diabetes. PMID: 21181396
    6. Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. PMID: 20943661
    7. molecular cloning, gene expression, and comparison with mouse protein PMID: 11688972
    8. Results suggest that elevated glucose concentrations rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet beta cells, followed by up-regulation by glucose of preproinsulin and pancreatic duodenum homeobox 1 gene expression. PMID: 15148392
    9. identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails PMID: 17595531

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 組織特異性：
    Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17270

    OMIM: 607505

    KEGG: hsa:23178

    STRING: 9606.ENSP00000234040

    UniGene: Hs.397891



主站蜘蛛池模板： 极品尤物被啪到呻吟喷水| 文中字幕一区二区三区视频播放| 色婷婷综合中文久久一本| 免费国产a国产片高清| 久久亚洲国产精品影院| 日本大肚子孕妇交xxx| 精品国内在视频线2019| 国产sm主人调教女m视频| 亚洲高清成人av电影网站| 国产性生大片免费观看性| 色噜噜av男人的天堂| 国产毛a片啊久久久久久保和丸 | 制服 丝袜 人妻 专区一本| 国产精品亚洲专区无码牛牛| 亚洲婷婷综合色香五月| 无码人妻一区、二区、三区免费视频| 国产欧美精品区一区二区三区| 无尺码精品产品日韩| 亚洲性无码一区二区三区| 97婷婷狠狠成为人免费视频| 国产美女在线精品免费观看网址| 精品人妻av区乱码| 久久香蕉国产线看观看怡红院妓院| 中文字幕在线精品视频入口一区 | 麻豆ā片免费观看在线看| 日韩国产综合精选| 国产乱来乱子视频| 精品一区二区三人妻视频| 一区二区三区四区在线不卡高清| 后入到高潮免费观看| 高清欧美性猛交xxxx黑人猛交| 一本大道久久香蕉成人网 | 国产精品无码久久av不卡| 国产精品成人午夜久久| 午夜精品久久久久久久无码| 国产亚洲精品ae86| 又色又爽又黄还免费毛片96下载| 中国少妇内射xxxx狠干| 欧美一区二区三区视频在线观看| 18禁超污无遮挡无码免费网站国产| 粉嫩小泬无遮挡久久久久久|