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  4. PASK Antibody, HRP conjugated

PASK Antibody, HRP conjugated

  • 中文名稱：
    PASK兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA822296LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PASK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PASK
  • 別名：
    DKFZP434O051 antibody; DKFZp686P2031 antibody; hPASK antibody; KIAA0135 antibody; MGC93882 antibody; mKIAA0135 antibody; PAS domain containing serine/threonine kinase antibody; PAS domain containing serine/threonine protein kinase antibody; PAS domain-containing serine/threonine-protein kinase antibody; PAS kinase antibody; PAS serine/threonine kinase antibody; PAS-kinase antibody; Pask antibody; PASK_HUMAN antibody; PASKIN antibody; STK 37 antibody; STK37 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PAS domain-containing serine/threonine-protein kinase protein (482-602AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
  • 基因功能參考文獻：
    1. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells. PMID: 23853095
    2. Mutations that affect PAS domain cause a severe protein trafficking defect and change the interactions with Kv11.1 channels. PMID: 23721480
    3. The role of PAS kinase in PASsing the glucose signal. PMID: 22219681
    4. Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion PMID: 22065581
    5. PASK is involved in the regulation of glucagon secretion by glucose and may be a useful target for the treatment of type 2 diabetes. PMID: 21181396
    6. Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. PMID: 20943661
    7. molecular cloning, gene expression, and comparison with mouse protein PMID: 11688972
    8. Results suggest that elevated glucose concentrations rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet beta cells, followed by up-regulation by glucose of preproinsulin and pancreatic duodenum homeobox 1 gene expression. PMID: 15148392
    9. identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails PMID: 17595531

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 組織特異性：
    Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).
  • 數據庫鏈接：

    HGNC: 17270

    OMIM: 607505

    KEGG: hsa:23178

    STRING: 9606.ENSP00000234040

    UniGene: Hs.397891



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