在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PARD6A Antibody

  • 中文名稱:
    PARD6A兔多克隆抗體
  • 貨號:
    CSB-PA280481
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA280481(PARD6A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA280481(PARD6A Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    0710008C04Rik antibody; 2610010A15Rik antibody; Par 6 partitioning defective 6 C elegans homolog alpha antibody; Par 6 partitioning defective 6 homolog alpha antibody; Par 6 partitioning defective 6 homolog alpha C elegans antibody; PAR 6A antibody; PAR-6 alpha antibody; PAR-6 antibody; par-6 family cell polarity regulator alpha antibody; PAR-6A antibody; PAR6 antibody; PAR6A_HUMAN antibody; PAR6alpha antibody; PAR6C antibody; Pard6a antibody; Partitioning defective 6 homolog alpha antibody; partitioning-defective protein 6 antibody; partitioning-defective protein 6, C. elegans, homolog of, alpha antibody; Tax interacting protein 40 antibody; Tax interaction protein 40 antibody; TAX40 antibody; TIP 40 antibody; TIP-40 antibody; TIP40 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human PARD6A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization.
  • 基因功能參考文獻:
    1. In T84 cells, overexpression of Par-6 causes intestinal barrier dysfunction. Lipopolysaccharide (LPS)-induced intestinal epithelial barrier dysfunction and increase in Par-6 expression was prevented by AhR activation. PMID: 29992488
    2. Studies indicate that the PAR3-PAR6-aPKC complex are important for the establishment of neuronal polarity [Review]. PMID: 29696344
    3. Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells PMID: 28590507
    4. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition PMID: 26050620
    5. TGFbeta induced Par6 phosphorylation on Ser345 and its recruitment to the leading edge of the membrane ruffle in migrating PC-3U cells, where it colocalised with aPKCzeta. The p-Par6-aPKCzeta complex is important for cell migration and invasion. PMID: 25756394
    6. Data indicate that both tumor focality and Par3/Par6/atypical protein kinase C (APKC) expression were significantly associated with tumor recurrence. PMID: 21549621
    7. BDNF can regulate formation of functional synapses by increasing the expression of the RhoA inhibitors, Par6C and Rnd3. PMID: 23762244
    8. Morg1 facilitates Par6-aPKC binding to Crb3 for definition of apical identity of epithelial cells. PMID: 23439680
    9. Par6 negatively regulates trophoblast fusion via its roles on tight junctions and cytoskeleton dynamics and provide novel insight into the contribution of this polarity marker in altered trophoblast cell fusion typical of preeclampsia. PMID: 23341197
    10. Atypical protein kinase C kinase activity, as well as an association with PAR6, were found to be important for PAR6 phosphorylation. PMID: 23249950
    11. Pak6 is a binding partner and a outatuve effector protein for the atypical rho GTPase cdc42 homologous protein. PMID: 22339630
    12. Data show that DDR1 coordinates the Par3/Par6 cell-polarity complex through its carboxy terminus, binding PDZ domains in Par3 and Par6. PMID: 21170030
    13. Par6alpha controls centrosome organization through its association with the dynactin subunit p150(Glued). PMID: 20719959
    14. Partitioning-defective protein 6 associated constitutively with endogenous aPKCs. PMID: 14976222
    15. crystal structure of the complex of PKCiota and Par6alpha PB1 domains to a resolution of 1.5 A PMID: 15590654
    16. A rare A/G polymorphism in the promoter of the Par6alpha gene is associated with reduced fasting glycaemia, increased glucose tolerance and reduced serum nonesterified fatty Acids concentrations. PMID: 15744531
    17. findings demonstrated that G-protein-activated phospholipase C-beta interacts with cell polarity proteins Par3 and Par6 to form protein complexes and to mediate downstream signal transduction PMID: 15782111
    18. Studies in this review confirm that signaling by Par6alpha controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections. PMID: 17050699
    19. We provide evidence for the existence of a distinct PAR protein complex in endothelial cells. Both PAR-3 and PAR-6 associate directly with the adherens junction protein vascular endothelial cadherin (VE-cadherin). PMID: 17057644
    20. Par6alpha-mediated inhibition of insulin-dependent glycogen synthesis in C2C12 cells depends on the direct interaction of Par6alpha with aPKC and on aPKC-mediated T34 phosphorylation of Akt1. PMID: 17335965
    21. Par6 was characterized as a dual-location protein. PMID: 17420281
    22. Shear stress-induced directed migratory polarity is modulated by exogenous growth factors and dependent on Par6 activity and shear stress direction in endothelial cells PMID: 17586613
    23. In vivo binding studies identified a novel mechanism of Par6 interaction, suggesting that the cell polarity machinery may serve to spatially restrict Rit signaling. PMID: 17976838
    24. Neph1-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity PMID: 18562307
    25. in addition to regulating cell polarization processes, Par6 is an inducer of cell proliferation in breast epithelial cells. PMID: 18922891
    26. Ect2 and PKCiota are genetically and functionally linked in NSCLC, acting to coordinately drive tumor cell proliferation and invasion through formation of an oncogenic PKCiota-Par6alpha-Ect2 complex. PMID: 19617897
    27. the TGFbeta-Par6 polarity pathway has a role in breast cancer progression PMID: 19667198

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    PAR6 family
  • 組織特異性:
    Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
  • 數據庫鏈接:

    HGNC: 15943

    OMIM: 607484

    KEGG: hsa:50855

    STRING: 9606.ENSP00000219255

    UniGene: Hs.112933



主站蜘蛛池模板: 久久人午夜亚洲精品无码区| 天堂а√在线中文在线新版 | 好爽好黄的视频| 午夜久久久久久禁播电影| 24小时日本在线www免费的| 免费看撕开奶罩揉吮奶头视频| 国产高清在线精品一区二区三区 | 国产xxxx视频在线观看| 中文在线а天堂中文在线新版| 97成人精品国语自产拍| 狠狠躁夜夜躁人人爽天天天天97 | 久久久噜噜噜久久熟女aa片| 中文字幕av无码免费一区| 插b内射18免费视频| 久久久综合亚洲色一区二区三区| 妖精色av无码国产在线看| 中文字幕av无码免费一区| 国产乡下三级全黄三级| 老太脱裤子让老头玩xxxxx| 久久无码无码久久综合综合| 67194熟妇在线直接进入| 久久青青草原国产免费播放| 高清情侣国语自产拍| 中国性欧美videofree精品| 久久精品免费一区二区三区| 国产呻吟久久久久久久92| 日本一二三区视频在线| 天天看片天天av免费观看| 蜜臀av999无码精品国产专区 | 少妇被又大又粗又爽毛片| 国模杨依粉嫩蝴蝶150p| 色播久久人人爽人人爽人人片av | 色欲天天天综合网| 国产在线精品99一区不卡| 国产乱人伦偷精品视频| 午夜美女裸体福利视频| 久久国产福利播放| 性欧美暴力猛交69hd| 伊人久久大香线蕉综合直播| 免费无码成人av片在线在线播放| 欧美丰满少妇xxxxx|