在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PARD6A Antibody, Biotin conjugated

  • 中文名稱:
    PARD6A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA878839LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PARD6A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    0710008C04Rik antibody; 2610010A15Rik antibody; Par 6 partitioning defective 6 C elegans homolog alpha antibody; Par 6 partitioning defective 6 homolog alpha antibody; Par 6 partitioning defective 6 homolog alpha C elegans antibody; PAR 6A antibody; PAR-6 alpha antibody; PAR-6 antibody; par-6 family cell polarity regulator alpha antibody; PAR-6A antibody; PAR6 antibody; PAR6A_HUMAN antibody; PAR6alpha antibody; PAR6C antibody; Pard6a antibody; Partitioning defective 6 homolog alpha antibody; partitioning-defective protein 6 antibody; partitioning-defective protein 6, C. elegans, homolog of, alpha antibody; Tax interacting protein 40 antibody; Tax interaction protein 40 antibody; TAX40 antibody; TIP 40 antibody; TIP-40 antibody; TIP40 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Partitioning defective 6 homolog alpha protein (248-344AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization.
  • 基因功能參考文獻:
    1. In T84 cells, overexpression of Par-6 causes intestinal barrier dysfunction. Lipopolysaccharide (LPS)-induced intestinal epithelial barrier dysfunction and increase in Par-6 expression was prevented by AhR activation. PMID: 29992488
    2. Studies indicate that the PAR3-PAR6-aPKC complex are important for the establishment of neuronal polarity [Review]. PMID: 29696344
    3. Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells PMID: 28590507
    4. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition PMID: 26050620
    5. TGFbeta induced Par6 phosphorylation on Ser345 and its recruitment to the leading edge of the membrane ruffle in migrating PC-3U cells, where it colocalised with aPKCzeta. The p-Par6-aPKCzeta complex is important for cell migration and invasion. PMID: 25756394
    6. Data indicate that both tumor focality and Par3/Par6/atypical protein kinase C (APKC) expression were significantly associated with tumor recurrence. PMID: 21549621
    7. BDNF can regulate formation of functional synapses by increasing the expression of the RhoA inhibitors, Par6C and Rnd3. PMID: 23762244
    8. Morg1 facilitates Par6-aPKC binding to Crb3 for definition of apical identity of epithelial cells. PMID: 23439680
    9. Par6 negatively regulates trophoblast fusion via its roles on tight junctions and cytoskeleton dynamics and provide novel insight into the contribution of this polarity marker in altered trophoblast cell fusion typical of preeclampsia. PMID: 23341197
    10. Atypical protein kinase C kinase activity, as well as an association with PAR6, were found to be important for PAR6 phosphorylation. PMID: 23249950
    11. Pak6 is a binding partner and a outatuve effector protein for the atypical rho GTPase cdc42 homologous protein. PMID: 22339630
    12. Data show that DDR1 coordinates the Par3/Par6 cell-polarity complex through its carboxy terminus, binding PDZ domains in Par3 and Par6. PMID: 21170030
    13. Par6alpha controls centrosome organization through its association with the dynactin subunit p150(Glued). PMID: 20719959
    14. Partitioning-defective protein 6 associated constitutively with endogenous aPKCs. PMID: 14976222
    15. crystal structure of the complex of PKCiota and Par6alpha PB1 domains to a resolution of 1.5 A PMID: 15590654
    16. A rare A/G polymorphism in the promoter of the Par6alpha gene is associated with reduced fasting glycaemia, increased glucose tolerance and reduced serum nonesterified fatty Acids concentrations. PMID: 15744531
    17. findings demonstrated that G-protein-activated phospholipase C-beta interacts with cell polarity proteins Par3 and Par6 to form protein complexes and to mediate downstream signal transduction PMID: 15782111
    18. Studies in this review confirm that signaling by Par6alpha controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections. PMID: 17050699
    19. We provide evidence for the existence of a distinct PAR protein complex in endothelial cells. Both PAR-3 and PAR-6 associate directly with the adherens junction protein vascular endothelial cadherin (VE-cadherin). PMID: 17057644
    20. Par6alpha-mediated inhibition of insulin-dependent glycogen synthesis in C2C12 cells depends on the direct interaction of Par6alpha with aPKC and on aPKC-mediated T34 phosphorylation of Akt1. PMID: 17335965
    21. Par6 was characterized as a dual-location protein. PMID: 17420281
    22. Shear stress-induced directed migratory polarity is modulated by exogenous growth factors and dependent on Par6 activity and shear stress direction in endothelial cells PMID: 17586613
    23. In vivo binding studies identified a novel mechanism of Par6 interaction, suggesting that the cell polarity machinery may serve to spatially restrict Rit signaling. PMID: 17976838
    24. Neph1-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity PMID: 18562307
    25. in addition to regulating cell polarization processes, Par6 is an inducer of cell proliferation in breast epithelial cells. PMID: 18922891
    26. Ect2 and PKCiota are genetically and functionally linked in NSCLC, acting to coordinately drive tumor cell proliferation and invasion through formation of an oncogenic PKCiota-Par6alpha-Ect2 complex. PMID: 19617897
    27. the TGFbeta-Par6 polarity pathway has a role in breast cancer progression PMID: 19667198

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    PAR6 family
  • 組織特異性:
    Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
  • 數據庫鏈接:

    HGNC: 15943

    OMIM: 607484

    KEGG: hsa:50855

    STRING: 9606.ENSP00000219255

    UniGene: Hs.112933



主站蜘蛛池模板: 久久婷婷香蕉热狠狠综合| 92精品成人国产在线观看| 国产麻传媒精品国产av| 少妇无码吹潮| 欧美日韩一区二区三区自拍| 国产日产亚洲系列最新美使用方法 | 97se亚洲国产综合自在线观看| 免费国产在线一区二区| 好爽好湿好硬好大免费视频| 超碰免费公开| 国产精品99久久久久久www| 奇米综合四色77777久久| 国产裸体歌舞一区二区| 久久久久久亚洲精品| 国产又爽又黄无码无遮挡在线观看| 少妇spa推油被扣高潮| 人妻熟妇乱又伦精品hd| 午夜dv内射一区二区| 任我撸在线视频| 掀开奶罩边吃边摸下娇喘视频| 国产精品欧美久久久久无广告| 日产精品久久久一区二区| av片在线观看免费| 天天看片天天av免费观看| 亚洲精品国产高清一线久久| 日韩欧美猛交xxxxx无码| 人妻少妇久久中文字幕456| 国产亚洲精品岁国产微拍精品| 手机在线看永久av片免费| 国产成人免费爽爽爽视频| 大肉大捧一进一出视频出来呀| 欧美精品中文字幕在线视| 无遮挡1000部拍拍拍免费| 特级无码毛片免费视频尤物| 人妻丝袜无码国产一区| 色综合久久久无码网中文| 国产成人一区二区三区别| 美女扒开奶罩露出奶头视频网站 | 久久久久无码精品国产不卡| 免费人成视频网站在线下载| 99精品国产一区二区三区a片|