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  4. OXR1 Antibody

OXR1 Antibody

  • 中文名稱：
    OXR1兔多克隆抗體
  • 貨號：
    CSB-PA030175
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    OXR1
  • 別名：
    C7 antibody; C7B antibody; Gm1238 antibody; Nbla00307 antibody; Nucleolar protein C7 antibody; Oxidation resistance 1 antibody; Oxidation resistance protein 1 antibody; Oxr1 antibody; OXR1_HUMAN antibody; Putative protein product of Nbla00307 antibody; rCG_59825 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Oxr1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be involved in protection from oxidative damage.
  • 基因功能參考文獻(xiàn)：
    1. OXR1 may act as a sensor of cellular oxidative stress to regulate the transcriptional networks required to detoxify reactive oxygen species and modulate cell cycle and apoptosis. PMID: 26616534
    2. Oxr1 serves as a potential therapeutic target for ALS and other neurodegenerative disorders characterized by TDP-43 or FUS pathology. PMID: 25792726
    3. OXR1 upregulates the expression of antioxidant genes via the p21 signaling pathway to suppress hydrogen peroxide-induced oxidative stress and maintain mtDNA integrity. PMID: 25236744
    4. The protein segment encoded by exon 8 plays an important role in the anti-oxidative function of the human OXR1 protein. PMID: 22873401
    5. Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage. PMID: 15060142
    6. human OXR1 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance. PMID: 17391516

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  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    OXR1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15822

    OMIM: 605609

    KEGG: hsa:55074

    STRING: 9606.ENSP00000405424

    UniGene: Hs.127286



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