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  4. OTX1 Antibody, Biotin conjugated

OTX1 Antibody, Biotin conjugated

  • 中文名稱：
    OTX1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA017298LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) OTX1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ38361 antibody; Homeobox protein OTX 1 antibody; Homeobox protein OTX1 antibody; MGC15736 antibody; Orthodenticle 1 antibody; Orthodenticle homeobox 1 antibody; Orthodenticle homolog 1 antibody; Orthodenticle1 antibody; Otx 1 antibody; otx1 antibody; OTX1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein OTX1 protein (29-244AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
  • 基因功能參考文獻：
    1. High OTX1 expression is associated with gastric cancer. PMID: 30066897
    2. We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects. PMID: 28599093
    3. OTX1 and OTX2 genes might have a role in the pathogenesis of different types of sinonasal neoplasms. PMID: 28348423
    4. Genitalia defects in these patients could result from the effect of OTX1. PMID: 25203062
    5. overexpression of OTX1 results in accumulation of colorectal cancer (CRC) cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression inhibits the proliferative and invasive capability of CRC cell lines PMID: 24388989
    6. XPO1 and OXT1 may contribute to ASD in 2p15-p16.1 deletion cases and non-deletion cases of ASD mapping to this chromosome region. PMID: 21750575
    7. established that the p53 protein directly induces OTX1 expression by acting on its promoter PMID: 21478910
    8. The early expression of OTX1 in proliferative cell layers of the human fetal brain supports the concept that this homeobox gene is important in neuronal cell development and differentiation. PMID: 20354145
    9. This study identifies OTX1 as a molecular marker for high-grade germinal center derived Non-Hodgkin Lymphoma PMID: 19893048
    10. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus candidate gene PMID: 11901358
    11. OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium. PMID: 18849347
    12. In the human fetal eye, OTX1 expression was confined to anterior retina. PMID: 19414065

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 組織特異性：
    Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8521

    OMIM: 600036

    KEGG: hsa:5013

    STRING: 9606.ENSP00000282549

    UniGene: Hs.734360



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