在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

OSBP Antibody, HRP conjugated

  • 中文名稱:
    OSBP兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA017254LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) OSBP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    OSBP
  • 別名:
    OSBP 1 antibody; OSBP antibody; OSBP1_HUMAN antibody; Oxysterol binding protein 1 antibody; Oxysterol-binding protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Oxysterol-binding protein 1 protein (628-802AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
  • 基因功能參考文獻:
    1. the component proteins of the machinery, OSBP, VAP, SAC1, and PITPNB, are all essential host factors for AiV replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP/OSBP/SAC1 with the AiV proteins and with ACBD3. PMID: 29367253
    2. results demonstrate that Sac1 expression in either the ER or Golgi apparatus has a minimal impact on the PI-4P that regulates OSBP activity or recruitment to contact sites PMID: 28471037
    3. Cholesterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP have been described. PMID: 28978670
    4. Data suggest that OSBP shifts the distribution of phosphatidylinositol 4-phosphate upon localization to endoplasmic reticulum-Golgi contact sites. PMID: 26601944
    5. Our results identify OspB as a regulator of mTORC1 and mTORC1-dependent cell proliferation early during S. flexneri infection and establish a role for IQGAP1 in mTORC1 signaling PMID: 26473364
    6. These results suggest that poliovirus proteins modulate PI4KB activity and provide PI4P for recruitment of OSBP to accumulate unesterified cholesterol on virus-induced membrane structure for formation of a virus replication complex. PMID: 24527995
    7. OSBP-mediated back transfer of phosphatidylinositol 4-phosphate might coordinate the transfer of other lipid species at the endoplasmic reticulum-Golgi interface. PMID: 24209621
    8. OSBP is required for efficient replication of intracellular S. Typhimurium. PMID: 21988961
    9. Data indicate that phosphorylation on two serine-rich motifs, S381-S391 (site 1) and S192, S195, S200 (site 2), specifically controls oxysterol-binding protein (OSBP) activity at the endoplasmic reticulum (ER). PMID: 22875984
    10. PKD negatively regulates HCV secretion/release by attenuating OSBP and CERT functions by phosphorylation inhibition. This study identifies the key role of the Golgi components in the HCV maturation process. PMID: 21285358
    11. Results identify a novel substrate of protein kinase D at the Golgi, the oxysterol-binding protein OSBP. PMID: 20444975
    12. This review summarizes recent evidence of sterol transfer activity by OSBP, suggesting seemingly disparate functions that could be the result of alterations in membrane sterol distribution or ancillary to this primary activity. PMID: 20545625
    13. Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies. PMID: 20178991
    14. OSBP was found to function as a cholesterol-binding scaffolding protein coordinating the activity of two phosphatases to control the extracellular signal-regulated kinase (ERK) signaling pathway PMID: 15746430
    15. Regulation of ceramide transport protein by OSBP, sterols, and vesicle-associated protein reveals a novel mechanism for integrating sterol regulatory signals with ceramide transport and phingomyelin synthesis in the Golgi apparatus. PMID: 16571669
    16. OSBP is able to sense both membrane cholesterol and oxidized sterols and link this information to the ERK1/2 signaling pathway. PMID: 18165705
    17. functional role of OSBP in the HCV maturation process. PMID: 19570870

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network.
  • 蛋白家族:
    OSBP family
  • 組織特異性:
    Widely expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8503

    OMIM: 167040

    KEGG: hsa:5007

    STRING: 9606.ENSP00000263847

    UniGene: Hs.597091



主站蜘蛛池模板: 精品无码国产污污污免费网站| 久久精品第九区免费观看| 啪啪无码人妻丰满熟妇| 欧美老熟妇乱大交xxxxx| 伊人久久大香线蕉avapp下载| 亚洲精品无码成人aaa片 | 少妇裸交aa大片| 国产精品熟女高潮视频| 东京热人妻无码一区二区av| 亚洲精品自产拍在线观看| 暖暖视频 免费 日本社区| 国产欧美亚洲日韩图片| 牛牛视频一区二区三区| 国产成人免费97在线观看| av无码国产精品色午夜| 日韩一区精品视频一区二区| 无码人妻丰满熟妇啪啪| 日韩高清亚洲日韩精品一区| 久久99av无色码人妻蜜| 人妻中出受孕 中文字幕在线| 亚洲精品蜜桃久久久久久| 亚洲国产v高清在线观看| 免费1级做爰片在线观看爱| 国内露脸少妇精品视频| 国产精品爽爽久久久久久竹菊| 狠狠狠色丁香综合婷婷久久| 免费无码肉片在线观看| 久久人人妻人人做人人爽| 亚洲中文字幕在线无码一区二区| 亚洲国产品综合人成综合网站| 久久久久久a亚洲欧洲av冫| 亚洲色18禁成人网站www| 欧美人与禽zozzo性伦交| 久久精品女人天堂av免费观看| 亚洲精品喷潮一区二区三区| 国产黄在线观看免费观看不卡| 欧美精品久久96人妻无码| 精品久久人人爽天天玩人人妻| 亚洲妇女水蜜桃av网网站| 成人免费无码视频在线网站| 少妇激情一区二区三区视频小说|