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  4. ONECUT2 Antibody, HRP conjugated

ONECUT2 Antibody, HRP conjugated

  • 中文名稱：
    ONECUT2兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA016337LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ONECUT2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ONECUT2
  • 別名：
    ONECUT2 antibody; HNF6B antibody; One cut domain family member 2 antibody; Hepatocyte nuclear factor 6-beta antibody; HNF-6-beta antibody; One cut homeobox 2 antibody; Transcription factor ONECUT-2 antibody; OC-2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human One cut domain family member 2 protein (214-331AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
  • 基因功能參考文獻：
    1. Bioinformatics-based prediction, combined with qRT-PCR analysis and Western blotting, identified Onecut2 and SIRT1 as the 2 prominent miR-9 target genes under the conditions tested. In this study, Onecut2 and SIRT1 were confirmed as miR-9 target genes, which will help future investigations to probe in greater detail the role of miR-9 in Nonalcoholic Fatty Liver Disease. PMID: 27756894
    2. Data show that ONECUT2, IGF2BP1, and ANXA2 proteins were confirmed to be microRNA-9 (miR-9) targets and aberrantly upregulated in hepatocellular carcinoma (HCC). PMID: 26547929
    3. our data showed that transcript factor Onecut2 is involved in the EMT, migration and invasion of CRC cells; miR-429 inhibits the initiation of EMT and regulated expression of EMT-related markers PMID: 24402783
    4. Mutations at the -5/-6 site of the F9 promotor account for the majority of hemophilia B Leyden cases and disrupt the binding of ONECUT1 and ONECUT2. PMID: 23472758
    5. OC2 transcription factor is a direct target of T-bet in type-1 T-helper cells. PMID: 18418398
    6. A CpG island proximal to ONECUT2 is frequently methylated in diffuse large B-cell lymphoma (DLBCL). PMID: 18288132

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    CUT homeobox family
  • 數據庫鏈接：

    HGNC: 8139

    OMIM: 604894

    KEGG: hsa:9480

    STRING: 9606.ENSP00000262095

    UniGene: Hs.194725



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