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  4. OLA1 Antibody

OLA1 Antibody

  • 中文名稱：
    OLA1兔多克隆抗體
  • 貨號：
    CSB-PA016318HA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: OLA1 antibody at 2µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Mouse stomach tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 28, 32 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA016318HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA016318HA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA016318HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) OLA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OLA1
  • 別名：
    DKFZp313H1942 antibody; DNA damage-regulated overexpressed in cancer 45 protein antibody; DOC45 antibody; EC 3.6.3 antibody; GBP45 antibody; GTP-binding protein 9 (putative) antibody; GTP-binding protein 9 antibody; GTP-binding protein PTD004 antibody; homologous yeast-44.2 protein antibody; Obg like ATPase 1 antibody; Obg-like ATPase 1 antibody; OLA1 antibody; OLA1_HUMAN antibody; PTD004 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Obg-like ATPase 1 protein (1-396AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，OLA1 Antibody (CSB-PA016318HA01HU)，的標記方式是Non-conjugated。對于OLA1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA016318HB01HU OLA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA016318HC01HU OLA1 Antibody, FITC conjugated
    Biotin CSB-PA016318HD01HU OLA1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
  • 基因功能參考文獻：
    1. No germline mutations were found in the OLA1 gene in in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer. PMID: 27271530
    2. OLA1 contributes to epithelial-mesenchymal transition by modulating the GSK3beta/Snail/E-cadherin signaling, and its overexpression is associated with clinical progression and poor survival in lung cancer patients. PMID: 26863455
    3. Our work suggests that OLA1 is a novel translational GTPase and plays a suppressive role in translation and cell survival, as well as cancer growth and progression. PMID: 26283179
    4. OLA1 plays an important negative role in cell adhesion and spreading, in part through the regulation of FAK expression and cofilin phosphorylation, and manipulation of OLA1 may lead to significant changes in cell adhesion and the associated phenotypes. PMID: 24486488
    5. OLA1 plays an important role in centrosome regulation together with BRCA1. PMID: 24289923
    6. Downregulation of OLA1 in mammalian cells by either RNAi or targeted gene disruption results in reduced steady-state levels of HSP70, impaired HSP70 induction by heat, and functionally, increased cellular sensitivity to heat shock. PMID: 23412384
    7. DOC45 is a novel ATPase that is linked to cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. PMID: 20053727
    8. knockdown of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS levels PMID: 19882753
    9. Results indicate that Gbp45/OLA1 plays important roles in cell proliferation and death related to mitochondrial function. PMID: 18536999
    10. OLA1 suppresses the antioxidant response through nontranscriptional mechanisms. PMID: 19706404

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, YchF/OLA1 subfamily
  • 組織特異性：
    Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.
  • 數據庫鏈接：

    HGNC: 28833

    OMIM: 611175

    KEGG: hsa:29789

    STRING: 9606.ENSP00000284719

    UniGene: Hs.157351



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