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  4. OGFR Antibody

OGFR Antibody

  • 中文名稱：
    OGFR兔多克隆抗體
  • 貨號：
    CSB-PA016311ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA016311ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA016311ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) OGFR Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OGFR
  • 別名：
    7 60 protein antibody; HGNC:15768 antibody; Met enkephalin receptor antibody; OGFr antibody; OGFR_HUMAN antibody; Opioid growth factor receptor antibody; Protein 7-60 antibody; Zeta Opioid Receptor antibody; Zeta type opioid receptor antibody; Zeta-type opioid receptor antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Opioid growth factor receptor protein (1-280AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
  • 基因功能參考文獻：
    1. Morphine interacts with OGFR and may suppress lung cancer proliferation and progression. PMID: 27167686
    2. The blockade of OGF signaling by MNTX releases cells from their arrest and boosts the effect of Doc PMID: 25853862
    3. The OGF-OGFr axis may be a feasible target for treatment of cancer of the ovary (i) in a prophylactic fashion, (ii) following cytoreduction or (iii) in conjunction with standard chemotherapy for additive effectiveness PMID: 23856908
    4. OGF-OGFr axis is a determinant of the progression of human ovarian cancer PMID: 22328595
    5. These data are the first to report that theOGFr system is a native biological regulator of cell proliferation in Hepatocellular carcinoma PMID: 19923357
    6. OGF and OGFR are present in follicular-derived thyroid cancers, and that OGF serves in a inhibitory manner to maintain homeostasis of cell proliferation. PMID: 19835629
    7. Gene therapy to reinstate more OGFr and enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression in head and neck cancers. PMID: 16685459
    8. Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers PMID: 16820893
    9. These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias. PMID: 17273790
    10. supports opioid growth factor receptor (OGFr) gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer. PMID: 18636152
    11. Results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the opioid growth factor (OGF)-OGF receptor axis to inhibit cell proliferation in normal cells. PMID: 18923142
    12. the regulation of cell proliferation by the OGF-OGFr axis is dependent on nucleocytoplasmic translocation and reliant on the integrity of two NLSs in OGFr to interact with transport receptors. PMID: 19244545
    13. Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis. PMID: 19297547
    14. Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers. PMID: 19675283

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.
  • 蛋白家族：
    Opioid growth factor receptor family
  • 組織特異性：
    Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15768

    OMIM: 606459

    KEGG: hsa:11054

    STRING: 9606.ENSP00000290291

    UniGene: Hs.67896



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