在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NUP62 Antibody

  • 中文名稱:
    NUP62兔多克隆抗體
  • 貨號:
    CSB-PA255769
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA255769(NUP62 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela cells, human brain malignant glioma tissue, NIH/3T3 cells, PC3 cells, A549 cells, Primary antibody: CSB-PA255769(NUP62 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    NUP62 antibody; Nuclear pore glycoprotein p62 antibody; 62 kDa nucleoporin antibody; Nucleoporin Nup62 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human NUP62
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
  • 基因功能參考文獻:
    1. it was revealed that a fraction of Nup62 was associated with mitotic spindle microtubule instead of spindle matrix, and the localization of Nup62 in the mitotic spindle depended on its three coiled-coil domains rather than Crm1, although Nup62 strongly interacted with Crm1 during mitosis. Moreover, depletion of Nup62 by small interference of RNA seriously induced the defects of chromosome alignment and spindle assembly PMID: 27298184
    2. Knockdown of Nup62 (and CaMKK2) reduced androgen receptor transcriptional activity in castrate resistant prostate cancer cells. PMID: 26552607
    3. Loss of presenilin (PS)1 function propagates tau accumulation through impairment of cargo-receptor protein p62-dependent tau degradation. PMID: 23794287
    4. Nup62 depletion leads to the appearance of multinucleated cells and induces the formation of multipolar centrosomes, centriole synthesis defects, dramatic spindle orientation defects, and centrosome component rearrangements that impair cell bi-polarity. PMID: 24107630
    5. Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase. PMID: 23777819
    6. that a patch of hydrophobic residues, 65LRLCV69, within the zinc-binding domain of HPV16 E7 mediates its nuclear import via hydrophobic interactions with the FG domain of the central channel nucleoporin Nup62. PMID: 24074597
    7. Nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes. PMID: 22558357
    8. Nup62 protein intact and properly localized in HSV-1-infected cells, and an ICP27 mutant deficient for Nup62 binding failed to inhibit cellular nucleocytoplasmic transport pathways. PMID: 22334672
    9. the cellular Nup62 is specifically recruited by HIV-1 IN and contribute to an efficient viral DNA integration. PMID: 22308026
    10. impact of overexpressed ORP8 on nSREBPs and their target mRNAs was inhibited in cells depleted of Nup62 PMID: 21698267
    11. Site-directed mutagenesis of putative cleavage sites in Nup62 identified six different positions that are cleaved by 2A(pro) in vitro. This analysis revealed that 2A(pro) cleavage sites were located between amino acids 103 and 298 in Nup62 PMID: 20622012
    12. Oxidative stress up-regulated the binding of Crm1 to Ran and affected multiple repeat-containing nucleoporins by changing their localization, phosphorylation, O-glycosylation, or interaction with other transport components. PMID: 19828735
    13. Relocation of cellular proteins and inhibition of nuclear import in HeLa cells during rhinovirus type 14 infections correlated with the degradation of p62 PMID: 12163599
    14. The formation of Nup358/p62 and p62/Nup153 complexes was restricted to interphase cells, whereas Nup214/p62 binding was detected in interphase as well as during mitosis. PMID: 16730000
    15. p62 has a cell type-specific role and is important in the degeneration of the basal ganglia in humans PMID: 16786527
    16. autoantibodies reacting with the 60 kDa component of NPCs target p62 nucleoporin PMID: 17960595
    17. Nuclear envelope permeabilization was accompanied by hyperphosphorylation of Nup62 in cells infected with wild-type mengovirus, whereas both of these alterations were suppressed in L-deficient virus mutants. PMID: 19144712

    顯示更多

    收起更多

  • 相關疾病:
    Infantile striatonigral degeneration (SNDI)
  • 亞細胞定位:
    Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    Nucleoporin NSP1/NUP62 family
  • 數據庫鏈接:

    HGNC: 8066

    OMIM: 271930

    KEGG: hsa:23636

    STRING: 9606.ENSP00000305503

    UniGene: Hs.574492



主站蜘蛛池模板: 精品久久久久久久久久久国产字幕| 中文天堂网www新版资源在线| 日韩 欧美 动漫 国产 制服| 极品少妇被啪到呻吟喷水| 啦啦啦中文在线观看日本| 亚洲色大成网站在线| 久久久国产精品无码一区二区| 国产真实伦在线观看| 少妇激情一区二区三区视频小说| 日韩av无码一区二区三区| 国产清纯在线一区二区www| 西西艺术人像摄影| 亚洲成av人在线观看网站| 日韩免费视频| 久久久噜噜噜久久中文字幕色伊伊| 免费无码黄动漫十八禁| 亚洲中文久久精品无码1| 无码国产精品一区二区色情男同| 日本高清视频色wwwwww色| 亚洲 欧美 清纯 校园 另类| 国产成人青青久久大片| 亚洲精品一区二区三区在线| 亚洲妇女行蜜桃av网网站| 欧美日韩人成视频在线播放| 日本丰满熟妇hd| 亚洲成a人片在线不卡一二三区| 久国产精品人妻aⅴ| 日韩免费码中文在线观看| 亚洲欧洲日韩综合久久| 欧美激情精品久久| 国产成人av综合久久| 日本少妇三级hd激情在线观看 | 亚洲 欧美 自拍 美腿 卡通| 久久激情五月丁香伊人| 无码国产精品一区二区免费式影视 | 欧美性色大片在线观看| 天天天狠天天碰天天爱| 日本亚洲欧洲无免费码在线| 中文字幕无码中文字幕有码| 在线精品视频一区二区| 精品国产卡一卡2卡3卡|