在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NUP62 Antibody, FITC conjugated

  • 中文名稱:
    NUP62兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA016204LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NUP62 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    NUP62 antibody; Nuclear pore glycoprotein p62 antibody; 62 kDa nucleoporin antibody; Nucleoporin Nup62 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Nuclear pore glycoprotein p62 protein (173-522AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
  • 基因功能參考文獻:
    1. it was revealed that a fraction of Nup62 was associated with mitotic spindle microtubule instead of spindle matrix, and the localization of Nup62 in the mitotic spindle depended on its three coiled-coil domains rather than Crm1, although Nup62 strongly interacted with Crm1 during mitosis. Moreover, depletion of Nup62 by small interference of RNA seriously induced the defects of chromosome alignment and spindle assembly PMID: 27298184
    2. Knockdown of Nup62 (and CaMKK2) reduced androgen receptor transcriptional activity in castrate resistant prostate cancer cells. PMID: 26552607
    3. Loss of presenilin (PS)1 function propagates tau accumulation through impairment of cargo-receptor protein p62-dependent tau degradation. PMID: 23794287
    4. Nup62 depletion leads to the appearance of multinucleated cells and induces the formation of multipolar centrosomes, centriole synthesis defects, dramatic spindle orientation defects, and centrosome component rearrangements that impair cell bi-polarity. PMID: 24107630
    5. Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase. PMID: 23777819
    6. that a patch of hydrophobic residues, 65LRLCV69, within the zinc-binding domain of HPV16 E7 mediates its nuclear import via hydrophobic interactions with the FG domain of the central channel nucleoporin Nup62. PMID: 24074597
    7. Nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes. PMID: 22558357
    8. Nup62 protein intact and properly localized in HSV-1-infected cells, and an ICP27 mutant deficient for Nup62 binding failed to inhibit cellular nucleocytoplasmic transport pathways. PMID: 22334672
    9. the cellular Nup62 is specifically recruited by HIV-1 IN and contribute to an efficient viral DNA integration. PMID: 22308026
    10. impact of overexpressed ORP8 on nSREBPs and their target mRNAs was inhibited in cells depleted of Nup62 PMID: 21698267
    11. Site-directed mutagenesis of putative cleavage sites in Nup62 identified six different positions that are cleaved by 2A(pro) in vitro. This analysis revealed that 2A(pro) cleavage sites were located between amino acids 103 and 298 in Nup62 PMID: 20622012
    12. Oxidative stress up-regulated the binding of Crm1 to Ran and affected multiple repeat-containing nucleoporins by changing their localization, phosphorylation, O-glycosylation, or interaction with other transport components. PMID: 19828735
    13. Relocation of cellular proteins and inhibition of nuclear import in HeLa cells during rhinovirus type 14 infections correlated with the degradation of p62 PMID: 12163599
    14. The formation of Nup358/p62 and p62/Nup153 complexes was restricted to interphase cells, whereas Nup214/p62 binding was detected in interphase as well as during mitosis. PMID: 16730000
    15. p62 has a cell type-specific role and is important in the degeneration of the basal ganglia in humans PMID: 16786527
    16. autoantibodies reacting with the 60 kDa component of NPCs target p62 nucleoporin PMID: 17960595
    17. Nuclear envelope permeabilization was accompanied by hyperphosphorylation of Nup62 in cells infected with wild-type mengovirus, whereas both of these alterations were suppressed in L-deficient virus mutants. PMID: 19144712

    顯示更多

    收起更多

  • 相關疾病:
    Infantile striatonigral degeneration (SNDI)
  • 亞細胞定位:
    Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    Nucleoporin NSP1/NUP62 family
  • 數據庫鏈接:

    HGNC: 8066

    OMIM: 271930

    KEGG: hsa:23636

    STRING: 9606.ENSP00000305503

    UniGene: Hs.574492



主站蜘蛛池模板: 六月丁香综合在线视频| 亚洲精品一区| 无码av天堂一区二区三区| 无码av动漫精品一区二区免费| 国产三级视频在线播放线观看| 欧美午夜刺激影院| 国产精品自在线拍国产电影| 国产a精彩视频精品视频下载| 人妻无码系列一区二区三区| 精品香蕉99久久久久网站| 亚洲国产无线乱码在线观看| 亚洲综合色婷婷七月丁香| 中国熟妇内谢69xxxxx| 人妻巨大乳hd免费看| 人妻少妇被粗大爽9797pw| 一区二区精品视频日本| 国产成人精品高清在线观看93| 午夜天堂av天堂久久久| 麻豆av一区二区三区久久| 国产精品青青在线观看爽| 欧美乱码卡一卡二卡三新区| 色拍拍欧美视频在线看| 99热这里只就有精品22| 国产亚洲精品福利视频| 无码超乳爆乳中文字幕| 少妇被粗大的猛烈进出免费视频 | 国产精品久久久久影院嫩草| 2020最新国产在线不卡a| 51福利国产在线观看午夜天堂| 日本一区二区在线播放| 国产xxxxx在线观看| 日韩av无码一区二区三区无码| 女女女女女裸体处开bbb| 精品久久久久久无码专区不卡| 2019久久视频这里有精品15| 欧美白丰满老太aaa片| 精品国产偷窥一区二区| 最新国产精品拍自在线观看| 男女做爰无遮挡性视频| 亚洲精品乱码久久久久久蜜桃| 无码专区—va亚洲v专区vr|