在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NTHL1 Antibody, FITC conjugated

  • 中文名稱:
    NTHL1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA016125LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NTHL1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase antibody; DNA glycoslyase/AP lyase antibody; Endonuclease III like protein 1 antibody; Endonuclease III-like protein 1 antibody; hNTH1 antibody; NTH 1 antibody; nth endonuclease III like 1 (E. coli) antibody; NTH endonuclease III Like 1 antibody; NTH1 antibody; NTHL 1 antibody; Nthl1 antibody; NTHL1_HUMAN antibody; OCTS 3 antibody; OCTS3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Endonuclease III-like protein 1 protein (31-312AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
  • 基因功能參考文獻:
    1. The processing of the lesions was evaluated by purified enzyme cocktails of hNTH1 and hOGG1 as well as with a HeLa cell extract. Interestingly, the yield of double-strand breaks (DSBs) resulting from the processing of the bistranded lesions are appreciably lower when the DNA is treated with the HeLa cell extract compared with the relevant purified enzyme cocktail in both models PMID: 30207305
    2. NTHL1 in these extracts was able to excise thymine glycol from both naked DNA and sites in nucleosomes that earlier studies had shown to be sterically accessible. However, the same extracts were able to excise lesions from sterically-occluded sites in nucleosomes only after the addition of Mg2+/ATP. PMID: 28709015
    3. WT NTHL1 (human) and Nth (E. coli) are remarkably alike with respect to specificity of glycosylase reaction, and although NTHL1 is a much slower enzyme than Nth, the tighter binding of NTHL1 compensates, resulting in similar kcat/Kd values for both enzymes with each of the substrates tested. For NTHL1 Gln287Ala, specificity for substrates positioned opposite G is lost, but not that of substrates positioned opposite A. PMID: 28292631
    4. We therefore found published evidence to support the association between variants in NTHL1 and RPS20 with CRC. PMID: 27713038
    5. Both Ntg1 and its human homologue, NTHL1, can be SUMO-modified in response to oxidative stress. PMID: 27839712
    6. NTH1 polymorphisms may be associated with non-small cell lung cancer pathogenesis. PMID: 26400813
    7. This study extends the description of biallelic mutations in NTHL1 beyond the single c.268C-->T,p.Q90* mutation that was observed previously. PMID: 26559593
    8. A homozygous loss-of-function germline mutation in the NTHL1 gene predisposes to a new subtype of BER-associated adenomatous polyposis and colorectal cancer. PMID: 25938944
    9. we demonstrated that hNEIL1 and hNTH1 cleave Oz sites as efficiently as 5-hydroxyuracil sites. Thus, hNEIL1 and hNTH1 can repair Oz lesions PMID: 22465744
    10. NTH1 is involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA PMID: 11328882
    11. recombinant hNTH1 lacking 55, 72 or 80 residues from the N terminus had four- to fivefold higher activities than the full-length enzyme PMID: 12144783
    12. substrate selectivity of mammalian NTH1 and the concomitant selective stimulation of activity by APE1 are indicative of selective repair of oxidative damage in different regions of the genome PMID: 12519758
    13. dimerization of hNTH1 involving the N-terminal tail masks the inhibitory effect of this tail and plays a critical role in its catalytic turnover in the cell PMID: 14522981
    14. hNTH1 and hNEIL1 but not hNEIL2 excised the two stereoisomers of thymine glycol (5R-Tg and 5S-Tg), but their isomer specificity was markedly different PMID: 14734554
    15. search for the factors interacting with NTH1 shows GST-NTH1 fusion protein precipitates proliferating cell nuclear antigen (PCNA) and p53 as well as XPG from human cell-free extracts PMID: 15358233
    16. NTH1 is a DNA glycosylase that excise 5-formyluracil, 5-hydroxymethyluracil and Thymine glycol in human cells. PMID: 15533839
    17. hNTH1 plays two roles in the processing of radiation damages: repair of potentially lethal single lesions and generation of lethal double strand breaks at clustered damage sites. PMID: 16111924
    18. Nth1 released 5R,6S 2'-deoxyribonucleoside diastereoisomer (Tg2) much more rapidly than cis 5S,6R-deoxyribonucleoside diastereoisomer (Tg1) regardless of the opposing purine. Neil1 released Thymine glycol non-stereoselectively. PMID: 16446124
    19. The damage specificity of human homologues of Endo III (hNTHl) and Endo VIII (hNEIL1 and hNEIL2) is compared to elucidate the repair role in cells. PMID: 17150535
    20. These observations suggest that access to sterically occluded lesions entails the partial, reversible unwrapping of DNA from the histone octamer, allowing hNTH1 to capture its DNA substrate when it is in an unwound state. PMID: 17923696
    21. Downregulation of NTH1 is associated with gastric cancer. PMID: 19414504

    顯示更多

    收起更多

  • 相關疾病:
    Familial adenomatous polyposis 3 (FAP3)
  • 亞細胞定位:
    Nucleus. Mitochondrion.
  • 蛋白家族:
    Nth/MutY family
  • 組織特異性:
    Widely expressed with highest levels in heart and lowest levels in lung and liver.
  • 數據庫鏈接:

    HGNC: 8028

    OMIM: 602656

    KEGG: hsa:4913

    STRING: 9606.ENSP00000219066

    UniGene: Hs.66196



主站蜘蛛池模板: 伊人www22综合色| 欧美丰满老妇性猛交| 中文字幕亚洲无线码在线一区| 熟女少妇精品一区二区| 国内精品久久久久影院老司机| 天堂va欧美ⅴa亚洲va在线| 国产99在线 | 欧美| 午夜成人亚洲理伦片在线观看| 强被迫伦姧惨叫人妻系列| 亚洲a片成人无码久久精品色欲| 国产精品久久久久一区二区三区| 成人无码www免费视频| 男女同房做爰爽免费| 亚洲最大无码av网站观看| 欧美自拍亚洲综合丝袜| 天堂8在线天堂资源bt| 国产成人av在线影院| 高潮喷吹一区二区在线观看| 国产亚洲日本精品无码| 精品亚洲成a人无码成a在线观看| 国语对白做受xxxxx在线中国 | 亚洲aⅴ综合色区无码一区| 中文字幕在线精品视频入口一区 | 欧美无遮挡很黄裸交视频| 国产97色在线 | 免| 饥渴少妇做私密保健视频| 国产成人午夜精品影院| 国产午夜激无码av毛片不卡| 国产第一页屁屁影院| 亚洲国产综合在线观看不卡| 国内揄拍国内精品少妇| 女人爽得直叫免费视频| 窝窝午夜看片成人精品| 日韩不卡1卡2卡三卡2021免费 | 国产精品久久久久久久久久直播 | 老牛精品亚洲成av人片| 国产午夜精品一区二区三区漫画| 亚洲成av人片在线播放无码| 成在线人免费视频| 精品偷拍被偷拍在线观看| 夜夜香夜夜摸夜夜添视频|