在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NRL Antibody

  • 中文名稱:
    NRL兔多克隆抗體
  • 貨號:
    CSB-PA016086LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of HepG2 cells with CSB-PA016086LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NRL Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NRL
  • 別名:
    D14S46E antibody; Neural retina-specific leucine zipper protein antibody; Neural retinal specific leucine zipper antibody; NRL antibody; NRL MAF antibody; NRL_HUMAN antibody; RP27 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Neural retina-specific leucine zipper protein (24-124AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,NRL Antibody (CSB-PA016086LA01HU),的標記方式是Non-conjugated。對于NRL Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA016086LB01HU NRL Antibody, HRP conjugated ELISA
    FITC CSB-PA016086LC01HU NRL Antibody, FITC conjugated
    Biotin CSB-PA016086LD01HU NRL Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.
  • 基因功能參考文獻:
    1. that two photoreceptor-specific transcription factors, NRL and CRX, are master regulators of this program and are required for tumor maintenance in this subgroup PMID: 29533784
    2. We identified a novel NRL mutation (c.147_149del, p.Ser50del) leading to adRP in a Chinese family with retinitis pigmenntosa. PMID: 28106895
    3. investigated the prevalence of the NRL mutation among Bukhara Jews with oculopharyngeal muscular dystrophy (OPMD) PMID: 28590779
    4. This report expands the spectrum of NRL recessive mutations, as well as the genetic spectrum of ESCS, and indicates a new syndrome of OPMD with an ESCS-like phenotype. PMID: 27732723
    5. The c.146 C>T mutation in NRL gene causes autosomal dominant retinitis pigmentosa for this family. PMID: 27081294
    6. In another family a variant, p.M96T in the NRL gene was detected as a retinitis pigmentosa-causing mutation. PMID: 23534816
    7. This novel p.M96T mutant activated the RHO promoter more intensely than did wild-type NRL in a family with autosomal dominant retinitis pigmentosa. PMID: 21981118
    8. Studies suggest an important role of sumoylation in fine-tuning the activity of NRL and thereby incorporating yet another layer of control in gene regulatory networks involved in photoreceptor development and homeostasis. PMID: 20551322
    9. In this study, NR2E3 mutations were found to be responsible for approximately 2.9% of overall retinitis pigmentosa (RP) in Chinese patients, NRL was not associated with RP. PMID: 19933183
    10. The disease caused by NRL mutations found in this study appears to be more severe PMID: 11879142
    11. Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene. PMID: 12552256
    12. the function of NRL is modulated by its interaction with specific repressor proteins, related to cross-talk between signaling pathways in the retina PMID: 12566383
    13. The NRL Ser50Thr mutation is associated with selective loss of scotopic function before age 20 years. With time, however, the photopic system becomes affected, leading to loss of the photopic visual field and of visual acuity. PMID: 12796249
    14. both Nrl and Crx are required for full transcriptional activity of the PDE6A gene PMID: 15001570
    15. the function of NRL-MTD is to activate transcription by recruiting or stabilizing TBP (and consequently other components of the general transcription complex) at the promoter of target genes PMID: 15328344
    16. Mutation analysis of the NRL gene, in patients with Enhanced S Cone Syndrome PMID: 15459973
    17. an unusual clinical phenotype in humans with loss-of-function mutations in NRL PMID: 15591106
    18. signaling by RA via RA receptors regulates the expression of NRL, providing a framework for delineating early steps in photoreceptor cell fate determination PMID: 16854989
    19. Gain-of-function mutations in the NRL gene cause autosomal dominant retinitis pigmentosa[RP] while loss-of-function mutations cause autosomal recessive RP. Differential phosphorylation of NRL fine-tunes its transcriptional regulatory activity. PMID: 17335001
    20. six isoforms of NRL (29-35 kDa) are generated by phosphorylation and expressed specifically in the mammalian retina. PMID: 11477108

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 27 (RP27); Retinal degeneration autosomal recessive clumped pigment type (RDCP)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    BZIP family
  • 組織特異性:
    Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level).
  • 數據庫鏈接:

    HGNC: 8002

    OMIM: 162080

    KEGG: hsa:4901

    STRING: 9606.ENSP00000380193

    UniGene: Hs.652297



主站蜘蛛池模板: 少妇爆乳无码专区网站| 久久无码av中文出轨人妻| 午夜免费国产体验区免费的| 97国产超碰一区二区三区| av中文无码韩国亚洲色偷偷| 国产国产乱老熟女视频网站97 | 国产亚洲精品久久久久久入口| 亚洲人成色77777在线观看大战| 亚洲国产av美女网站| 无遮挡又爽又刺激的视频| 日本道免费精品一区二区| 亚洲成l人在线观看线路| 国产午夜片无码区在线播放| 无码人妻久久一区二区三区 | 国产亚洲精品久久久ai换| 国产自偷在线拍精品热| 人妻无码中字在线a| 久久天天躁狠狠躁夜夜avapp| 精品久久久久久无码专区| 久久婷婷狠狠综合激情| 欧美精品免费观看二区| 欧美人与动人物牲交免费观看久久| 精品国产小视频在线观看 | 亚洲国产三级在线观看| 午夜免费啪视频| 亚洲精品久久久久久成人| 最新无码a∨在线观看| 午夜精品一区二区三区在线观看| 少妇做爰免费视看片| 一区二区三区鲁丝不卡麻豆| 亚洲国产美女精品久久久久| 亚洲一区二区三区写真| 亚洲国产午夜精华无码福利| 精品亚洲aⅴ在线无码播放| 99久热在线精品996热是什么| 亚洲欧美日韩综合久久久| 麻豆国产丝袜白领秘书在线观看 | 2021国产精品一卡2卡三卡4卡| 午夜福利不卡片在线机免费视频| 亚洲成a人v欧美综合天堂| 亚洲级αv无码毛片久久精品|