在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NRL Antibody

  • 中文名稱:
    NRL兔多克隆抗體
  • 貨號(hào):
    CSB-PA003487
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using Nrl Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    NRL
  • 別名:
    D14S46E antibody; Neural retina-specific leucine zipper protein antibody; Neural retinal specific leucine zipper antibody; NRL antibody; NRL MAF antibody; NRL_HUMAN antibody; RP27 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human Nrl.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.
  • 基因功能參考文獻(xiàn):
    1. that two photoreceptor-specific transcription factors, NRL and CRX, are master regulators of this program and are required for tumor maintenance in this subgroup PMID: 29533784
    2. We identified a novel NRL mutation (c.147_149del, p.Ser50del) leading to adRP in a Chinese family with retinitis pigmenntosa. PMID: 28106895
    3. investigated the prevalence of the NRL mutation among Bukhara Jews with oculopharyngeal muscular dystrophy (OPMD) PMID: 28590779
    4. This report expands the spectrum of NRL recessive mutations, as well as the genetic spectrum of ESCS, and indicates a new syndrome of OPMD with an ESCS-like phenotype. PMID: 27732723
    5. The c.146 C>T mutation in NRL gene causes autosomal dominant retinitis pigmentosa for this family. PMID: 27081294
    6. In another family a variant, p.M96T in the NRL gene was detected as a retinitis pigmentosa-causing mutation. PMID: 23534816
    7. This novel p.M96T mutant activated the RHO promoter more intensely than did wild-type NRL in a family with autosomal dominant retinitis pigmentosa. PMID: 21981118
    8. Studies suggest an important role of sumoylation in fine-tuning the activity of NRL and thereby incorporating yet another layer of control in gene regulatory networks involved in photoreceptor development and homeostasis. PMID: 20551322
    9. In this study, NR2E3 mutations were found to be responsible for approximately 2.9% of overall retinitis pigmentosa (RP) in Chinese patients, NRL was not associated with RP. PMID: 19933183
    10. The disease caused by NRL mutations found in this study appears to be more severe PMID: 11879142
    11. Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene. PMID: 12552256
    12. the function of NRL is modulated by its interaction with specific repressor proteins, related to cross-talk between signaling pathways in the retina PMID: 12566383
    13. The NRL Ser50Thr mutation is associated with selective loss of scotopic function before age 20 years. With time, however, the photopic system becomes affected, leading to loss of the photopic visual field and of visual acuity. PMID: 12796249
    14. both Nrl and Crx are required for full transcriptional activity of the PDE6A gene PMID: 15001570
    15. the function of NRL-MTD is to activate transcription by recruiting or stabilizing TBP (and consequently other components of the general transcription complex) at the promoter of target genes PMID: 15328344
    16. Mutation analysis of the NRL gene, in patients with Enhanced S Cone Syndrome PMID: 15459973
    17. an unusual clinical phenotype in humans with loss-of-function mutations in NRL PMID: 15591106
    18. signaling by RA via RA receptors regulates the expression of NRL, providing a framework for delineating early steps in photoreceptor cell fate determination PMID: 16854989
    19. Gain-of-function mutations in the NRL gene cause autosomal dominant retinitis pigmentosa[RP] while loss-of-function mutations cause autosomal recessive RP. Differential phosphorylation of NRL fine-tunes its transcriptional regulatory activity. PMID: 17335001
    20. six isoforms of NRL (29-35 kDa) are generated by phosphorylation and expressed specifically in the mammalian retina. PMID: 11477108

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Retinitis pigmentosa 27 (RP27); Retinal degeneration autosomal recessive clumped pigment type (RDCP)
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    BZIP family
  • 組織特異性:
    Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 8002

    OMIM: 162080

    KEGG: hsa:4901

    STRING: 9606.ENSP00000380193

    UniGene: Hs.652297



主站蜘蛛池模板: 久久精品蜜芽亚洲国产av| 在线 | 国产精品99传媒丿| 国产午夜无码片在线观看| 国内精品久久久久久tv| 日韩精品区一区二区三vr| 色欲天天网站欧美成人福利网| 亚洲精品av一区在线观看| 国产日韩在线视看第一页| 对白脏话肉麻粗话av| 日韩精品一区二区av在线观看| 日本熟妇厨房xxxxx乱| 国产熟妇精品高潮一区二区三区 | 欧美怡春院一区二区三区| 亚洲精品无码av中文字幕电影网站| 又色又爽又黄的美女裸体网站 | 成人无码免费一区二区三区| 国产99久一区二区三区a片| 美女粉嫩饱满的一线天mp4| 四虎精品成人a在线观看| 少妇性饥渴无码a区免费| 国产精品有码无码av在线播放| 亚洲成a人v电影在线观看| 色欲国产麻豆一精品一av一免费| 久久久精品人妻久久影视| 丁香五月缴情在线| 久久精品国产清高在天天线| 欧美性大战久久久久xxx| 欧美xxxx做受欧美| 狠狠色狠狠色综合网老熟女| 五月天天天综合精品无码| 97碰碰碰人妻无码视频| 在线 | 麻豆国产传媒61国产免费 视频在线+欧美十亚洲曰本 | 欧洲 亚洲 国产图片综合| 国产日产欧美最新| 欧美激情性做爰免费视频| 国产第一页浮力影院入口| 日本日本乱码伦专区| 又粗又硬又大又爽免费视频播放| 99j久久精品久久久久久| 亚洲精品无码中文久久字幕| 中文字幕亚韩|